Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring

Autor: Julie C. Savage, Nathalie Vernoux, Maude Bordeleau, M. Mallar Chakravarty, Lourdes Fernández de Cossío, Chloé Lacabanne, Marie-Ève Tremblay

Publikováno v: Brain, Behavior, & Immunity-Health, Vol 15, Iss, Pp 100281-(2021)
Brain, Behavior, & Immunity-Health

Prenatal exposure to maternal high-fat diet (mHFD) acts as a risk factor for various neurodevelopmental alterations in the progeny. Recent studies in mice revealed that mHFD results in both neuroinflammation and hypomyelination in the exposed offspri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bbff113a515765bfb16988a44b0d4c
http://www.sciencedirect.com/science/article/pii/S2666354621000843

Antagonistic functions of MBP and CNP establish cytosolic channels in CNS myelin

Autor: Caroline Velte, Petri Kursula, Klaus-Armin Nave, Alexander Ignatev, Mikael Simons, Arne Raasakka, Nicolas Snaidero, Wiebke Möbius, Michelle S Erwig, Hauke B. Werner, Matti Myllykoski

Publikováno v: Cell Reports, Vol 18, Iss 2, Pp 314-323 (2017)
Cell reports
Cell Reports
Cell reports 18(2), 314-323 (2017). doi:10.1016/j.celrep.2016.12.053

Summary The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa90f04ceb2b7ded0ca7c2b44689146
http://urn.fi/urn:nbn:fi-fe201704055960