The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

Autor: Diederik W. D. Kuster, Michel van Weeghel, Vida Alizadeh Tazehkandi, Luciënne Baks-Te Bulte, Gustav J. Strijkers, Bram F. Coolen, Ntsiki M. Held, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Mariah R R Daal, Marit Wiersma, Rob C. I. Wüst

Publikováno v: Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100 . https://doi.org/10.3390/ijms22084100
International journal of molecular sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(8):4100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 8
Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100, pp. 1-19 . https://doi.org/10.3390/ijms22084100
International Journal of Molecular Sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 4100, p 4100 (2021)

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba143ec8e34cf744f53dea11e2bd5101
https://doi.org/10.3390/ijms22084100

Modular Redesign of a Cationic Lytic Peptide To Promote the Endosomal Escape of Biomacromolecules

Autor: Azuma, Y., Imai, H., Kawaguchi, Y., Nakase, I., Kimura, Hiroshi, Futaki, S.

Publikováno v: Angewandte Chemie. 130:12953-12956

Endocytosis is an important route for the intracellular delivery of biomacromolecules, wherein their inefficient endosomal escape into the cytosol remains a major barrier. Based on the understanding that endosomal membranes are negatively charged, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490acf64ff3bb1bc2f9bd9f180236753
https://doi.org/10.1002/ange.201807534

The novel chloroplast outer membrane kinase KOC1 is a required component of the plastid protein import machinery

Autor: Cyrille Montandon, Birgit Agne, Emilie Demarsy, Mónica Zufferey, Sacha Baginsky, Felix Kessler, Véronique Douet

Publikováno v: Journal of Biological Chemistry, Vol. 292, No 17 (2017) pp. 6952-6964

The biogenesis and maintenance of cell organelles such as mitochondria and chloroplasts require the import of many proteins from the cytosol, a process that is controlled by phosphorylation. In the case of chloroplasts, the import of hundreds of diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b92c05f604c1f98b865515b073e1d84
https://doi.org/10.1074/jbc.m117.776468

Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model

Autor: S. Lazar, Karen Søgaard, Jenny Hadrévi, Niels Ørtenblad, Gisela Sjøgaard, Mary F. Barbe, Ulrik Frandsen, Eleanor Boyle

Publikováno v: BioMed Research International, Vol 2019 (2019)
Hadrevi, J, Barbe, M F, Ørtenblad, N, Frandsen, U, Boyle, E, Lazar, S, Sjøgaard, G & Søgaard, K 2019, ' Calcium Fluxes in Work-Related Muscle Disorder : Implications from a Rat Model ', BioMed Research International, vol. 2019, 5040818 . https://doi.org/10.1155/2019/5040818, https://doi.org/10.1155/2019/5040818
BioMed Research International

Introduction. Ca2+ regulatory excitation-contraction coupling properties are key topics of interest in the development of work-related muscle myalgia and may constitute an underlying cause of muscle pain and loss of force generating capacity. Method.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32943e3265bf5dc03e4ea05863f2fdb0

Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery

Autor: Hagmann, V, Sommer, S, Fabian, P, Bierlmeier, J, van Treel, N, Mootz, H, Schwarzer, D, Azevedo, JE, Dodt, G

Publikováno v: Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Peroxisomal matrix proteins contain either a peroxisomal targeting sequence 1 (PTS1) or a PTS2 that are recognized by the import receptors PEX5 and PEX7, respectively. PEX5 transports the PTS1 proteins and the PEX7/PTS2 complex to the docking translo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::79ebb51d4a98a51b27821208dc565b67
https://pubmed.ncbi.nlm.nih.gov/30375424