Zobrazeno 1 - 10
of 979
pro vyhledávání: '"Cytolytic activity"'
Autor:
Abdulaziz Almutairi, Najlaa A. Alshehri, Abdullah Al Subayyil, Eman Bahattab, Manal Alshabibi, Fawaz Abomaray, Yasser S. Basmaeil, Tanvir Khatlani
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionMesenchymal stem cells/stromal cells from the Decidua Basalis of the human placenta (DBMSCs) express wide range of effector molecules that modulate the functions of their target cells. These properties make them potential candidate for us
Externí odkaz:
https://doaj.org/article/098c692bc24b42bf865d6d20842cb719
Akademický článek
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Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1764-1782 (2021)
Human leukocyte antigen (HLA) genotyping gains intensive attention due to its critical role in cancer immunotherapy. It is still a challenging issue to generate reliable HLA genotyping results through in silico tools. In addition, the survival impact
Externí odkaz:
https://doaj.org/article/17f2127152de424dbb867f4553482a17
Autor:
Wei Yuen Yap, Jung Shan Hwang
Publikováno v:
Toxins, Vol 15, Iss 6, p 396 (2023)
Hydra actinoporin-like toxin 4 (HALT-4) differs from other actinoporins due to its N-terminal propart that contains approximately 103 additional residues. Within this region, we identified five dibasic residues and assumed that, when cleaved, they co
Externí odkaz:
https://doaj.org/article/2c3f77ca261f43278309b294554c7cf5
Autor:
Samo Guzelj, Žiga Jakopin
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nucleotide-binding oligomerization domain 1 (NOD1) receptor and Toll-like receptor 4 (TLR4) belong to the family of pattern recognition receptors. Interactions between these receptors profoundly shape the innate immune responses. We previously demons
Externí odkaz:
https://doaj.org/article/3e90d05adb1540238f5ccdab060a42f3
Publikováno v:
eLife, Vol 11 (2022)
Mucosal-associated invariant T (MAIT) cells belong to a family of innate-like T cells that bridge innate and adaptive immunities. Although MAIT cells have been implicated in tumor immunity, it currently remains unclear whether they function as tumor-
Externí odkaz:
https://doaj.org/article/3b371701e6d5409bb3cb8b8c05dffce7
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Skin cutaneous melanoma (SKCM) attracts attention worldwide for its extremely high malignancy. A novel term cytolytic activity (CYT) has been introduced as a potential immunotherapy biomarker associated with counter-regulatory immune responses and en
Externí odkaz:
https://doaj.org/article/92ca804d0fc246a3893b2783d94d0368
Autor:
Wenyan Zhong, Jeremy S. Myers, Fang Wang, Kai Wang, Justin Lucas, Edward Rosfjord, Judy Lucas, Andrea T. Hooper, Sharon Yang, Lu Anna Lemon, Magali Guffroy, Chad May, Jadwiga R. Bienkowska, Paul A. Rejto
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background The clinical success of immune checkpoint inhibitors demonstrates that reactivation of the human immune system delivers durable responses for some patients and represents an exciting approach for cancer treatment. An important cla
Externí odkaz:
https://doaj.org/article/8611614a41274bc88abf31f1a71b7264
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background Immune checkpoint inhibitors have achieved unprecedented success in cancer immunotherapy. With the exception of a few candidate biomarkers, the prognostic role of soluble immune checkpoint-related proteins in clear cell renal cell
Externí odkaz:
https://doaj.org/article/82fd77773de7480d8e21c4902e8bf016
Autor:
Xiaolian Gu, Linda Boldrup, Philip J Coates, Robin Fahraeus, Lixiao Wang, Torben Wilms, Lena Norberg‐Spaak, Nicola Sgaramella, Karin Nylander
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 5, Iss 4, Pp 240-247 (2019)
Abstract Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A
Externí odkaz:
https://doaj.org/article/665c6e99d71e40f0964646992cb9be99