Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis

Autor: Pedersen, Janni Maria, Hansen, Aida Solhøj, Skejø, Cæcilie, Juul-Madsen, Kristian, Junker, Peter, Hørslev-Petersen, Kim, Hetland, Merete Lund, Stengaard-Pedersen, Kristian, Østergaard, Mikkel, Møller, Bjarne Kuno, Dreyer, Lene, Hauge, Ellen-Margrethe, Hvid, Malene, Greisen, Stinne, Deleuran, Bent

Publikováno v: Pedersen, J M, Hansen, A S, Skejø, C, Juul-Madsen, K, Junker, P, Hørslev-Petersen, K, Hetland, M L, Stengaard-Pedersen, K, Østergaard, M, Møller, B K, Dreyer, L, Hauge, E M, Hvid, M, Greisen, S & Deleuran, B 2023, ' Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis ', Arthritis Research and Therapy, vol. 25, no. 1, 97 . https://doi.org/10.1186/s13075-023-03073-z
Pedersen, J M, Hansen, A S, Skejø, C, Juul-Madsen, K, Junker, P, Hørslev-Petersen, K, Hetland, M L, Stengaard-Pedersen, K, Østergaard, M, Møller, B K, Dreyer, L, Hauge, E-M, Hvid, M, Greisen, S & Deleuran, B 2023, ' Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis ', Arthritis Research & Therapy, vol. 25, no. 1, 97 . https://doi.org/10.1186/s13075-023-03073-z

BackgroundLymphocyte activation gene-3 (LAG-3) inhibits T cell activation and interferes with the immune response by binding to MHC-II. As antigen presentation is central in rheumatoid arthritis (RA) pathogenesis, we studied aspects of LAG-3 as a ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::33271edfee5f653ef0d5ee2daad97e49
https://pure.au.dk/portal/da/publications/lymphocyte-activation-gene-3-is-increased-and-affects-cytokine-production-in-rheumatoid-arthritis(c4cab09a-a3fc-44ba-8234-a4ecf3785a17).html

Cytokine Secretion, Viability, and Real-Time Proliferation of Apical-Papilla Stem Cells Upon Exposure to Oral Bacteria

Autor: Olena Rakhimova, Alexej Schmidt, Maréne Landström, Anders Johansson, Peyman Kelk, Nelly Romani Vestman

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)

The use of stem cells from the apical papilla (SCAPs) has been proposed as a means of promoting root maturation in permanent immature teeth, and plays a significant role in regenerative dental procedures. However, the role of SCAPs may be compromised

Externí odkaz: https://doaj.org/article/3070124457574284828c519800c3921d

NAMPT-dependent NAD + biosynthesis controls circadian metabolism in a tissue-specific manner

Autor: Astrid L. Basse, Karen N. Nielsen, Iuliia Karavaeva, Lars R. Ingerslev, Tao Ma, Jesper F. Havelund, Thomas S. Nielsen, Mikkel Frost, Julia Peics, Emilie Dalbram, Morten Dall, Juleen R. Zierath, Romain Barrès, Nils J. Færgeman, Jonas T. Treebak, Zachary Gerhart-Hines

Publikováno v: Basse, A L, Nielsen, K N, Karavaeva, I, Ingerslev, L R, Ma, T, Havelund, J F, Nielsen, T S, Frost, M, Peics, J, Dalbram, E, Dall, M, Zierath, J R, Barrès, R, Færgeman, N J, Treebak, J T & Gerhart-Hines, Z 2023, ' NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 14, e2220102120 . https://doi.org/10.1073/pnas.2220102120

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from the hypothalamic master clock and intracellular metabolic signals. One such key metabolic signal is the cellular concentration of NAD + , which os

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c273dfdf97b93fab97fdc623e5cb7f38
https://doi.org/10.1073/pnas.2220102120

Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells

Autor: Jianfei He, Jonas Hyld Steffen, Peter Waaben Thulstrup, Jannik Nedergaard Pedersen, Max B. Sauerland, Daniel E. Otzen, Clare L. Hawkins, Pontus Gourdon, Michael J. Davies, Per Hägglund

Publikováno v: He, J, Steffen, J H, Thulstrup, P W, Pedersen, J N, Sauerland, M B, Otzen, D E, Hawkins, C L, Gourdon, P, Davies, M J & Hägglund, P 2022, ' Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells ', Scientific Reports, vol. 12, no. 1, 22051 . https://doi.org/10.1038/s41598-022-26359-9

Anastellin, a recombinant protein fragment from the first type III module of fibronectin, mimics a partially unfolded intermediate implicated in the assembly of fibronectin fibrils. Anastellin influences the structure of fibronectin and initiates in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2e3a6986e64ae6fed03c2e29c8b41b
https://pure.au.dk/portal/da/publications/anastellin-impacts-on-the-processing-of-extracellular-matrix-fibronectin-and-stimulates-release-of-cytokines-from-coronary-artery-smooth-muscle-cells(fd4aba68-64f0-4461-a77f-fba1c79a6e38).html

Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies

Autor: Wang, Lei, van Iersel, Lieke E J, Pelgrim, Charlotte E, Lu, Jingyi, van Ark, Ingrid, Leusink-Muis, Thea, Gosker, Harry R, Langen, Ramon C J, Schols, Annemie M W J, Argilés, Josep M, van Helvoort, Ardy, Kraneveld, Aletta D, Garssen, Johan, Henricks, Paul A J, Folkerts, Gert, Braber, Saskia, Afd Pharmacology, Pharmacology

Publikováno v: Cells, 11(18):2893. Multidisciplinary Digital Publishing Institute (MDPI)
Cells; Volume 11; Issue 18; Pages: 2893
Cells, 11(18), 1. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, 11(18):2893. MDPI AG

Chronic obstructive pulmonary disease (COPD), often caused by smoking, is a chronic lung disease with systemic manifestations including metabolic comorbidities. This study investigates adaptive and pathological alterations in adipose and skeletal mus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dda9457573fefd081417be07f626b20
https://cris.maastrichtuniversity.nl/en/publications/a4ed5fe0-c1e3-41c3-ac22-4e5f7facbc86