Association between age and the host response in critically ill patients with sepsis

Autor: Michels, Erik H. A., Butler, Joe M., Reijnders, Tom D. Y., Cremer, Olaf L., Scicluna, Brendon P., Uhel, Fabrice, Peters-Sengers, Hessel, Schultz, Marcus J., Knight, Julian C., van Vught, Lonneke A., van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T. M., Horn, Janneke, Huson, Mischa A., Schouten, Laura R. A., Straat, Marleen, Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Bonten, Marc J. M., Cremer, Olaf M., Ong, David S. Y., Frencken, Jos F., Klouwenberg, Peter M. C. Klein, Koster‐Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M.

Publikováno v: Critical Care, 26(1):385. Springer Science + Business Media
Critical Care
MARS consortium 2022, ' Association between age and the host response in critically ill patients with sepsis ', Critical Care, vol. 26, no. 1, 385 . https://doi.org/10.1186/s13054-022-04266-9

Background: The association of ageing with increased sepsis mortality is well established. Nonetheless, current investigations on the influence of age on host response aberrations are largely limited to plasma cytokine levels while neglecting other p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76133b79f7b32d0a5384ec4b904a46bb
https://pure.amc.nl/en/publications/association-between-age-and-the-host-response-in-critically-ill-patients-with-sepsis(d7aca8b2-205f-46b1-96f2-6c898ea4486e).html

An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration

Autor: René Lutter, Augustijn M. Klarenbeek, Natasja A. Otto, Brendon P. Scicluna, Bastiaan W. Haak, Wanhai Qin, Joe M. Butler, Marja E. Jakobs, Daniël R. Faber, Tom van der Poll, Fabrice Uhel, Xanthe Brands, W. Joost Wiersinga

Publikováno v: Genome Medicine
Genome medicine, 13(1):131. BioMed Central
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)

Background: The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba68325200e3b4c61839e46b30b56bd8
https://doi.org/10.1186/s13073-021-00948-1

The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients

Autor: Mauro Oddo, Gérard Waeber, Peter Vollenweider, Pedro Marques-Vidal, Jade Ghosn, Cédric Laouénan, Craig Fenwick, Madeleine Suffiotti, Matthieu Perreau, Giuseppe Pantaleo, Aurélie Wiedemann, Yves Levy, Jean Regina, Denis Comte, Thierry Calandra, Thierry Roger

Publikováno v: Nature communications, vol. 12, no. 1, pp. 4888
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

The objective of the present study was to identify biological signatures of severe coronavirus disease 2019 (COVID-19) predictive of admission in the intensive care unit (ICU). Over 170 immunological markers were investigated in a ‘discovery’ coh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfbf4dda3a47aaecca044160f664bba
https://serval.unil.ch/notice/serval:BIB_D985FAB1BA6B

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement

Autor: Nash, Peter, Kerschbaumer, Andreas, Dörner, Thomas, Dougados, Maxime, Fleischmann, Roy M, Geissler, Klaus, McInnes, Iain, Pope, Janet E, van der Heijde, Désirée, Stoffer-Marx, Michaela, Takeuchi, Tsutomu, Trauner, Michael, Winthrop, Kevin L, de Wit, Maarten, Aletaha, Daniel, Baraliakos, Xenofon, Boehncke, Wolf-Henning, Emery, Paul, Isaacs, John D, Kremer, Joel, Lee, Eun Bong, Maksymowych, Walter P, Voshaar, Marieke, Tam, Lai-Shan, Tanaka, Yoshiya, van den Bosch, Filip, Westhovens, René, Xavier, Ricardo, Smolen, Josef S

Publikováno v: Annals of the Rheumatic Diseases, Vol. 80, No 1 (2021) pp. 71-87

Janus kinase inhibitors (JAKi) have been approved for use in various immune-mediated inflammatory diseases. With five agents licensed, it was timely to summarise the current understanding of JAKi use based on a systematic literature review (SLR) on e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::1182f33d31346539fe8ba8ba42fbc434
https://archive-ouverte.unige.ch/unige:154811

A melhora do condicionamento físico aeróbico na sensibilização e na inflamação e remodelamento das vias aéreas de camundongos

Autor: Silva, Anna Cecilia Duarte da

A prevalência de doenças respiratórias alérgicas tem aumentado, embora de origem multifatorial, a atividade física parece representar um importante contribuinte. Objetivo: Nós hipotetizamos que o condicionamento aeróbio (AC) prévio à sensibi

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/5/5160/tde-15062009-155758/