Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Cytochrome p450c17"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Progesterone has been shown to have neuroprotective capabilities against a wide range of nervous system injuries, however there are negative clinical studies that have failed to demonstrate positive effects of progesterone therapy. Specifically, we l
Externí odkaz:
https://doaj.org/article/0dcf3c2a87194afea0bf72826b8b8bd0
Akademický článek
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Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
We have recently demonstrated that sciatic nerve injury increases the expression of spinal cytochrome P450c17, a key neurosteroidogenic enzyme, which plays a critical role in the development of peripheral neuropathic pain. However, the modulatory mec
Externí odkaz:
https://doaj.org/article/3f51bb93d87449df898516352d3a0dd8
Publikováno v:
World Journal of Clinical Cases
BACKGROUND p.Tyr329fs is a cytochrome P450c17 mutation among Chinese individuals. However, data on 17-α-hydroxylase deficiency caused by cytochrome P450c17 p.Tyr329fs homozygous mutation are lacking. This paper is a case report of three patients hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f159dbaa125f1c4a4b6baf04968ba5f6
http://europepmc.org/articles/PMC7953410
http://europepmc.org/articles/PMC7953410
Akademický článek
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Publikováno v:
Genetics and Molecular Biology, Vol 25, Iss 4, Pp 361-364 (2002)
Estrogen plays a role in the pathogenesis of leiomyoma. The CYP17 gene codes for the cytochrome P450c17alpha enzyme, which is involved in the biosynthesis of estrogen. Our aim was to investigate if CYP17 polymorphism could be a useful marker to predi
Externí odkaz:
https://doaj.org/article/97ae514e4fdb450d9294a5580bb03eb4
Akademický článek
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Publikováno v:
Biomedicine & Pharmacotherapy, Vol 118, Iss, Pp-(2019)
We have recently demonstrated that the neurosteroid-metabolizing enzyme, cytochrome P450c17 is increased in spinal astrocytes contributing to the development of mechanical allodynia in chronic constriction injury (CCI)-induced neuropathic mice. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f30f4cd8afdd3e8a6928ab44b0a9098
http://www.sciencedirect.com/science/article/pii/S0753332219329993
http://www.sciencedirect.com/science/article/pii/S0753332219329993
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience, Vol 12 (2019)
We have recently demonstrated that sciatic nerve injury increases the expression of spinal cytochrome P450c17, a key neurosteroidogenic enzyme, which plays a critical role in the development of peripheral neuropathic pain. However, the modulatory mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8f1fcca7857e0c3437d915e0f76d61
https://doi.org/10.3389/fnmol.2019.00153
https://doi.org/10.3389/fnmol.2019.00153
Publikováno v:
Experimental Neurobiology
We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b731a9b8b954ffbd5be3dc905dc741f8
https://pubmed.ncbi.nlm.nih.gov/31495080
https://pubmed.ncbi.nlm.nih.gov/31495080