Zobrazeno 1 - 10
of 865
pro vyhledávání: '"Cytochrome P450 2E1"'
Autor:
Huiqiong Zou, Yingying Cao, Peipei Hao, Ziqi Jin, Ruifeng Ding, Xuefeng Bai, Kun Zhang, Yongzhi Xue
Publikováno v:
Heliyon, Vol 9, Iss 12, Pp e22641- (2023)
The extent of immune-mediated hepatic damage (such as in viral hepatitis) is characterised by the downregulation of cytochrome P450s (CYPs), a class of drug-metabolising enzymes. However, whether this downregulation aids liver cells in maintaining th
Externí odkaz:
https://doaj.org/article/849792ea42fa465abbdd898f053821f2
Publikováno v:
Veterinární Medicína, Vol 67, Iss 5, Pp 245-256 (2022)
We investigated the effect of an albumin infusion on the enzyme activity, expression level of cytochrome P450 2E1 (CYP2E1), and oxidative stress in the serum and liver of streptozotocin (STZ)-induced diabetic rats. The STZ treatment enhanced the alan
Externí odkaz:
https://doaj.org/article/6cf20d0caf244bca8c7786a68bb77a05
Publikováno v:
Life, Vol 13, Iss 8, p 1662 (2023)
Alcohol effect hepatic lipid metabolism through various mechanisms, leading synergistically to an accumulation of fatty acids (FA) and triglycerides. Obesity, as well as dietary fat (saturated fatty acids (FA) versus poly-unsaturated fatty acids (PUF
Externí odkaz:
https://doaj.org/article/84a2045355904e0b80e3c9c427f1fef4
Autor:
Cheng Chen, Shijin Wang, Linna Yu, Johannes Mueller, Franco Fortunato, Vanessa Rausch, Sebastian Mueller
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102081- (2021)
Background: Alcoholic liver disease (ALD) is the most common liver disease worldwide and its underlying molecular mechanisms are still poorly understood. Moreover, conflicting data have been reported on potentially protective autophagy, the exact rol
Externí odkaz:
https://doaj.org/article/84d3cea967204be1a378eff6c41f27eb
Autor:
Torsten Diesinger, Alfred Lautwein, Vyacheslav Buko, Elena Belonovskaya, Oksana Lukivskaya, Elena Naruta, Siarhei Kirko, Viktor Andreev, Radovan Dvorsky, Dominik Buckert, Sebastian Bergler, Christian Renz, Dieter Müller‐Enoch, Thomas Wirth, Thomas Haehner
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract Cytochrome P450 2E1 (CYP2E1)‐associated reactive oxygen species production plays an important role in the development and progression of inflammatory liver diseases such as alcoholic steatohepatitis. We developed two new inhibitors for thi
Externí odkaz:
https://doaj.org/article/7650c6afdea94e30a21387f69ebfb9bd
Autor:
Jelena Marković Filipović, Marko Miler, Danijela Kojić, Jelena Karan, Ivana Ivelja, Jovana Čukuranović Kokoris, Milica Matavulj
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6062 (2022)
Acrylamide (AA) toxicity is associated with oxidative stress. During detoxification, AA is either coupled to gluthatione or biotransformed to glycidamide by the enzyme cytochrome P450 2E1 (CYP2E1). The aim of our study was to examine the hepatotoxici
Externí odkaz:
https://doaj.org/article/53c4c0e81dcf49388687f80fda0fa821
Akademický článek
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Akademický článek
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Autor:
Ting Wang, Huihui Du, Jingsong Ma, Lu Shen, Muyun Wei, Xianglong Zhao, Luan Chen, Mo Li, Guorong Li, Qinghe Xing, Lin He, Shengying Qin
Publikováno v:
PeerJ, Vol 8, p e9628 (2020)
Backgrounds Cytochrome P450 (P450) 2E1 is one of the primary enzymes responsible for the metabolism of xenobiotics, such as drugs and environmental carcinogens. The genetic polymorphisms of the CYP2E1 gene in promoter and coding regions have been ide
Externí odkaz:
https://doaj.org/article/d932c4de346144a4bd254c72c9967942
Publikováno v:
Cells, Vol 11, Iss 2, p 288 (2022)
Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing oxidative stress, mitochondrial dysfunction and cell death. In addition, thi
Externí odkaz:
https://doaj.org/article/4d00432af2bb422e8054990d7a22686d