Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

Autor: Jill Barber, Peter Kilford, Amin Rostami-Hodjegan, Mian Zhang, Brahim Achour, Agnieszka Grybos‐Gajniak, David Knight, Kristi Lea, Jeoffrey Schageman, Zubida M. Al-Majdoub

Publikováno v: Achour, B, Al-Majdoub, Z, Grybos-Gajniak, A, Lea, K, Kilford, P, Zhang, M, Knight, D, Barber, J, Schageman, J & Rostami-Hodjegan, A 2021, ' Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters ', Clinical Pharmacology & Therapeutics, vol. 109, no. 1, pp. 222-232 . https://doi.org/10.1002/cpt.2102
Clinical Pharmacology and Therapeutics

Variability in individual capacity for hepatic elimination of therapeutic drugs is well recognized and is associated with variable expression and activity of liver enzymes and transporters. Whilst genotyping offers some degree of stratification, ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c238b140b46c89b5a4303f9ebc2bc10d
https://doi.org/10.1002/cpt.2102

The effect of inflammation on voriconazole through concentrations in children

Autor: ter Avest, M., Veringa, A., van den Heuvel, E.R., Kosterink, J.G.W., Schölvinck, E.H., Tissing, W.J.E., Alffenaar, J.W.C.

Publikováno v: British Journal of Clinical Pharmacology, 83(3), 678-680. Wiley-Blackwell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::ea7942bd50fc36d7d950fc9c399fa5da
https://research.tue.nl/nl/publications/b7707ea7-7225-457e-9781-6a2ed01711f3

Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization

Autor: Jérôme Collemare, Abraham Vaisberg, Scott A. Griffiths, Russell J. Cox, Pierre J. G. M. de Wit, Carl H. Mesarich, Benedetta Saccomanno

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 113 (2016) 25
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (25), pp.6851-6856. ⟨10.1073/pnas.1603528113⟩
Proceedings of the National Academy of Sciences of the United States of America, 113(25), 6851-6856
Proceedings of the National Academy of Sciences of the United States of America 25 (113), 6851-6856. (2016)

International audience; Anthraquinones are a large family of secondary metabolites (SMs) that are extensively studied for their diverse biological activities. These activities are determined by functional group decorations and the formation of dimers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8257aca31619e090d1d26edda60ec8d3
https://hdl.handle.net/20.500.12866/5076

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Autor: Aleksandra Galetin, Ruedi Aebersold, Aleksanteri Petsalo, Mariette Matondo, Oliver Hatley, Aki T. Heikkinen, Neil Parrott, Jens Lamerz, Paul Cutler, Amin Rostami-Hodjegan, Arno Friedlein, Risto O. Juvonen, Tom Dunkley

Publikováno v: Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2015, 32 (1), pp.74-90. ⟨10.1007/s11095-014-1446-8⟩

International audience; PURPOSE:Beagle dogs are used to study oral pharmacokinetics and guide development of drug formulations for human use. Since mechanistic insight into species differences is needed to translate findings in this species to human,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257c5cba2077adb8e58c7d78d4df4281
https://hal-pasteur.archives-ouvertes.fr/pasteur-02573666

Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma

Autor: Marija Bosilkovska, Julien Déglon, Caroline Samer, Bernhard Walder, Jules Desmeules, Christian Staub, Youssef Daali

Publikováno v: Bioanalysis, Vol. 6, No 2 (2014) pp. 151-64

Background: An LC–MS/MS method has been developed for the simultaneous quantification of P-glycoprotein (P-gp) and cytochrome P450 (CYP) probe substrates and their Phase I metabolites in DBS and plasma. P-gp (fexofenadine) and CYP-specific substrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823f87e425da750fe7eb01110c590f69
https://archive-ouverte.unige.ch/unige:43679