Výsledky vyhledávání - "Cytochrome P-450 CYP2C19/genetics"

CYP2C19 genotype-guided antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease

Autor: Kranendonk, J, Willems, L H, Vijver-Coppen, Rj van der, Coenen, M, Adang, E, Donders, R, Zeebregts, C J, Deneer, V, Reijnen, Mmpj, Kramers, C, Warlé, M C, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

Publikováno v: American heart journal, 254, 141-148. Mosby Inc.
American Heart Journal, 254, 141. Mosby Inc.
American Heart Journal, 254, 141-148
American Heart Journal, 254, 141-148. MOSBY-ELSEVIER
American Heart Journal, 254, pp. 141-148

Background: Clopidogrel is recommended in international guidelines to prevent arterial thrombotic events in patients with peripheral arterial disease (PAD). Clopidogrel itself is inactive and metabolism is dependent on the CYP2C19 enzyme. About 30% o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23557701c0ab2cfcf57d875031a80c4
https://research.rug.nl/en/publications/6a261d34-34ba-4a4b-bdde-6d7e483bc2b5

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Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P‐Glycoprotein Activities

Autor: Brahim Achour, Pauline Gosselin, Jean Terrier, Yvonne Gloor, Zubida M. Al‐Majdoub, Thomas M. Polasek, Youssef Daali, Amin Rostami‐Hodjegan, Jean‐Luc Reny

Publikováno v: Achour, B, Gosselin, P, Terrier, J, Gloor, Y, Al-Majdoub, Z M, Polasek, T M, Daali, Y, Rostami-Hodjegan, A & Reny, JL 2022, ' Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P-Glycoprotein Activities ', Clinical Pharmacology & Therapeutics, vol. 111, no. 6, pp. 1268-1277 . https://doi.org/10.1002/cpt.2576

Precision dosing strategies require accounting for between-patient variability in pharmacokinetics together with subsequent pharmacodynamic differences. Liquid biopsy is a valuable new approach to diagnose disease prior to the appearance of clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14807b84e70786f828ddd5d31b521437
https://doi.org/10.1002/cpt.2576

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Bedside testing of CYP2C19 vs. conventional clopidogrel treatment to guide antiplatelet therapy in ST-segment elevation myocardial infarction patients

Autor: Amein K. Al-Ali, Rudaynah A. Alali, Folkert W. Asselbergs, Chittibabu Vatte, Abdullah M. Al-Rubaish, Mohammed M. Sulieman, Abdullah M. Alshehri, Fahad Al-Muhanna, Cyril Cyrus, Daniel M.F. Claassens, Mohammed Almansori, Rania M. Khalil, Khalid A. Al-Faraidy, Bao-Li Loza

Publikováno v: International journal of cardiology, 343, 15-20. Elsevier Ireland Ltd

Background ST-segment elevation myocardial infarction (STEMI) patients are treated with dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor. Clopidogrel is widely used in these patients in several areas worldwide, such as Middle East,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2510ae790b46c1924db2657ca61c0184
https://doi.org/10.1016/j.ijcard.2021.08.051

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Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Autor: Okhuijsen-Pfeifer, C., van der Horst, M. Z., Bousman, C. A., Lin, B., van Eijk, K. R., Ripke, S., Ayhan, Y., Babaoglu, M. O., Bak, M., Alink, W., van Beek, H., Beld, E., Bouhuis, A., Edlinger, M., Erdogan, I. M., Ertuğrul, A., Yoca, G., Everall, I. P., Görlitz, T., van Amelsvoort, T., Bartels-Velthuis, A. A., Bruggeman, R., Cahn, W., Guloksuz, S., de Haan, L., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Os, J., Alizadeh, B. Z., Luykx, J. J., Rutten, B. P. F., van Winkel, R., Grootens, K. P., Gutwinski, S., Hallikainen, T., Jeger-Land, E., de Koning, M., Lähteenvuo, M., Legge, S. E., Leucht, S., Morgenroth, C., Müderrisoğlu, A., Narang, A., Pantelis, C., Pardiñas, A. F., Oviedo-Salcedo, T., Schneider-Thoma, J., Schreiter, S., Repo-Tiihonen, E., Tuppurainen, H., Veereschild, M., Veerman, S., de Vos, M., Wagner, E., Cohen, D., Bogers, J. P. A. M., Walters, J. T. R., Yağcıoğlu, A. E. Anil, Tiihonen, J., Hasan, A.

Publikováno v: Translational Psychiatry, 12(1):145. Nature Publishing Group
Translational psychiatry, 12(1):145. Nature Publishing Group

Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d35979803fbaf570d9245558fcc0da
https://research.rug.nl/en/publications/68c11f0b-1d30-47b1-b8cc-469ae7b6003c

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Prevalence of CYP2C19*2 carriers in Saudi ischemic stroke patients and the suitability of using genotyping to guide antiplatelet therapy in a university hospital setup

Autor: Abdullah M. Al-Rubaish, Fahad A. Al-Muhanna, Abdullah M. Alshehri, Abdulla A. Alsulaiman, Majed M. Alabdulali, Fahad Alkhamis, Abdulallh S. Alamri, Rudaynah A. Alali, Mohammed S. Akhtar, Cyril Cyrus, Daniel M.F. Claassens, Folkert W. Asselbergs, Amein K. Al-Ali

Publikováno v: Drug Metabolism and Personalized Therapy, 37(1), 35-40. Walter de Gruyter GmbH

Objectives To mitigate the incidence of recurrent stroke in patients, dual antiplatelet therapy comprising aspirin and clopidogrel is usually administered. Clopidogrel is a prodrug and its bioactivation is catalyzed by cytochrome P450 (CYP)2C19. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa4550dad8b70f1514f7cf4d3eaa081
https://doi.org/10.1515/dmpt-2021-0104

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CYP2C19 expression modulates affective functioning and hippocampal subiculum volume: A large single-center community-dwelling cohort study

Autor: Claire, Grosu, Olga, Trofimova, Mehdi, Gholam-Rezaee, Marie-Pierre F, Strippoli, Ferath, Kherif, Antoine, Lutti, Martin, Preisig, Bogdan, Draganski, Chin B, Eap

Publikováno v: Translational Psychiatry
Translational psychiatry, vol. 12, no. 1, pp. 316

Given controversial findings of reduced depressive symptom severity and increased hippocampus volume in CYP2C19 poor metabolizers, we sought to provide empirical evidence from a large-scale single-center longitudinal cohort in the community-dwelling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::70632c69d36c91caede2c5b0068a672b
https://hdl.handle.net/21.11116/0000-000A-EF91-521.11116/0000-000A-EF93-3

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A Genotype-Guided Strategy for Oral P2Y(12) Inhibitors in Primary PCI

Publikováno v: New England Journal of Medicine, 381(17), 1621-1631. MASSACHUSETTS MEDICAL SOCIETY
New England Journal of Medicine, 381(17), 1621-1631. MASSACHUSETTS MEDICAL SOC
New England Journal of Medicine, 381, 1621. Massachussetts Medical Society
New England Journal of Medicine, 381(17), 1621. Massachussetts Medical Society

BackgroundIt is unknown whether patients undergoing primary percutaneous coronary intervention (PCI) benefit from genotype-guided selection of oral P2Y(12) inhibitors.MethodsWe conducted a randomized, open-label, assessor-blinded trial in which patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733c98faebcd29c4b96c53bc67fcb7de
https://hdl.handle.net/11370/650391a9-784b-433f-a595-a7bf8062502a

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Clopidogrel Versus Ticagrelor or Prasugrel After Primary Percutaneous Coronary Intervention According to CYP2C19 Genotype A POPular Genetics Subanalysis

Autor: Vera H.M. Deneer, Renicus S Hermanides, Carmine Morisco, Richard M. Tjon Joe Gin, Gerrit J.A. Vos, Arend Mosterd, Pim van der Harst, Daniel M.F. Claassens, Jean-Paul R. Herrman, Johannes C. Kelder, Willem Dewilde, Paul W.A. Janssen, Bakhtawar K. Mahmoodi, Arnoud W J van 't Hof, Jurriën M. ten Berg, Folkert W. Asselbergs, Thomas O. Bergmeijer, Emanuele Barbato

Publikováno v: Circulation-Cardiovascular interventions, 14(4):009434, 402-411. LIPPINCOTT WILLIAMS & WILKINS
Circulation. Cardiovascular interventions, 14(4). Lippincott Williams and Wilkins
Circulation: Cardiovascular Interventions, 14(4), 402. Lippincott Williams and Wilkins Ltd.
Circulation-Cardiovascular Interventions, 14(4):009434, 402-411. LIPPINCOTT WILLIAMS & WILKINS

Background: Guidelines favor ticagrelor or prasugrel over clopidogrel in patients with myocardial infarction. However, the POPular Genetics trial (Patient Outcome After Primary Percutaneous Coronary Intervention [PCI]) showed that in patients with pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54ef6016a26fcea7ac724e7cf6c3723
https://research.rug.nl/en/publications/c88d7bed-0522-46be-abfa-3331f07b3fe4

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Clopidogrel responder status is uninfluenced by CYP2C19∗2 in Danish patients with stroke

Autor: Niklas Rye Jørgensen, Troels Wienecke, Charlotte Lützhøft Rath

Publikováno v: Rath, C L, Jørgensen, N R & Wienecke, T 2020, ' Clopidogrel responder status is uninfluenced by CYP2C19∗2 in Danish patients with stroke ', PLoS ONE, vol. 15, no. 12, e0236260 . https://doi.org/10.1371/journal.pone.0236260
Rath, C L, Jorgensen, N R & Wienecke, T 2020, ' Clopidogrel responder status is uninfluenced by CYP2C19*2 in Danish patients with stroke ', PLOS ONE, vol. 15, no. 12, e0236260 . https://doi.org/10.1371/journal.pone.0236260
PLoS ONE, Vol 15, Iss 12, p e0236260 (2020)
PLoS ONE

Background Antiplatelet therapy is a cornerstone of secondary stroke prevention, but the responsiveness to antiplatelet medication varies among patients. Clopidogrel is a pro-drug that requires hepatic transformation to reach its active metabolite. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b31e27f0a034dae1328db6ae0459b1
https://curis.ku.dk/portal/da/publications/clopidogrel-responder-status-is-uninfluenced-by-cyp2c192-in-danish-patients-with-stroke(5eb8beca-932f-4541-b056-8ea52a9ffb83).html

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