Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cytochrome P-450 CYP1A2/genetics"'
Autor:
Okhuijsen-Pfeifer, C., van der Horst, M. Z., Bousman, C. A., Lin, B., van Eijk, K. R., Ripke, S., Ayhan, Y., Babaoglu, M. O., Bak, M., Alink, W., van Beek, H., Beld, E., Bouhuis, A., Edlinger, M., Erdogan, I. M., Ertuğrul, A., Yoca, G., Everall, I. P., Görlitz, T., van Amelsvoort, T., Bartels-Velthuis, A. A., Bruggeman, R., Cahn, W., Guloksuz, S., de Haan, L., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Os, J., Alizadeh, B. Z., Luykx, J. J., Rutten, B. P. F., van Winkel, R., Grootens, K. P., Gutwinski, S., Hallikainen, T., Jeger-Land, E., de Koning, M., Lähteenvuo, M., Legge, S. E., Leucht, S., Morgenroth, C., Müderrisoğlu, A., Narang, A., Pantelis, C., Pardiñas, A. F., Oviedo-Salcedo, T., Schneider-Thoma, J., Schreiter, S., Repo-Tiihonen, E., Tuppurainen, H., Veereschild, M., Veerman, S., de Vos, M., Wagner, E., Cohen, D., Bogers, J. P. A. M., Walters, J. T. R., Yağcıoğlu, A. E. Anil, Tiihonen, J., Hasan, A.
Publikováno v:
Translational Psychiatry, 12(1):145. Nature Publishing Group
Translational psychiatry, 12(1):145. Nature Publishing Group
Translational psychiatry, 12(1):145. Nature Publishing Group
Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d35979803fbaf570d9245558fcc0da
https://research.rug.nl/en/publications/68c11f0b-1d30-47b1-b8cc-469ae7b6003c
https://research.rug.nl/en/publications/68c11f0b-1d30-47b1-b8cc-469ae7b6003c
Autor:
Matthaei, Johannes, Tzvetkov, Mladen V, Strube, Jakob, Sehrt, Daniel, Sachse-Seeboth, Cordula, Hjelmborg, Jacob v. B., Möller, Sören, Halekoh, Ulrich, Hofmann, Ute, Schwab, Matthias, Kerb, Reinhold, Brockmöller, Jürgen
Publikováno v:
Matthaei, J, Tzvetkov, M V, Strube, J, Sehrt, D, Sachse-Seeboth, C, Hjelmborg, J V B, Möller, S, Halekoh, U, Hofmann, U, Schwab, M, Kerb, R & Brockmöller, J 2016, ' Heritability of caffeine metabolism : Environmental effects masking genetic effects on CYP1A2 activity but not on NAT2 ', Clinical Pharmacology & Therapeutics, vol. 100, no. 6, pp. 606-616 . https://doi.org/10.1002/cpt.444
Heritability of caffeine pharmacokinetics and cytochrome P450 1A2 (CYP1A2) activity is controversial. Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3062::1ff4e5cd2dd5d73af006082d3f0cada4
https://portal.findresearcher.sdu.dk/da/publications/505827fa-2eef-4b06-a5cf-bf68b63fa2b3
https://portal.findresearcher.sdu.dk/da/publications/505827fa-2eef-4b06-a5cf-bf68b63fa2b3
Autor:
Peter Holmans, Udo Seedorf, Beverley M. Shields, Peter McGruffin, Arne Pfeufer, Steve Eyre, Nathalie J. Prescott, Michael Boehnke, Valentina Moskovina, Abiodun Onipinla, Leena Peltonen, Nadira Yuldasheva, Peter M. Nilsson, Valeria Romanazzi, Vincent Mooser, Göran Berglund, Alistair S. Hall, Dominic P. Kwiatkowski, Barry Widmer, Benjamin F. Voight, Stefania Bandinelli, Mark M. Iles, Sven Bergmann, Thomas Meitinger, James P. Boorman, Simonetta Guarrera, Nazneen Rahman, Murielle Bochud, Graham A. Hitman, Emma Keniry, Nelson B. Freimer, Richard Dobson, Francis S. Collins, Gerjan Navis, Jennifer L. Pointon, Richard N. Bergman, Ruth J. F. Loos, Roberto Lorbeer, Carolina A. Braga Marcano, Christian Gieger, Florian Ernst, Xin Yuan, Catherine Potter, Hazel E. Drummond, Allan H. Young, George Kirov, John F. Peden, Helen Stevens, David Clayton, Mattijs E. Numans, Katherine Gordon-Smith, Anne Farmer, Alastair Forbes, M. Khalid Mohiuddin, John A. Todd, Christopher G. Mathew, David A. Collier, Mark I. McCarthy, Francesca Bredin, Clive M. Onnie, Dan Davidson, Markus Perola, Pamela Whittaker, Yvonne T. van der Schouw, Rathi Ravindrarajan, I. C.A. Spencer, Teresa Ferreira, Nilesh J. Samani, Serge Hercberg, Gonçalo R. Abecasis, Christopher J. Groves, Nicholas John Craddock, Angela Döring, Edward G. Lakatta, Muminatou Jallow, Wendy L. McArdle, David Bentley, Susana Eyheramendy, Uwe Völker, Christopher Newton-Cheh, Jaspal S. Kooner, Hugh Watkins, Gavin Lucas, H. T. Leung, Marjo Ritta Jarvelin, Johanna Kuusisto, Wiek H. van Gilst, Wendy Thomson, Lou R. Cardon, Harold Snieder, Marju Orho-Melander, Patricia B. Munroe, Toshiko Tanaka, Jeffrey C. Barrett, Azhar Maqbool, Henry Völzke, John M. C. Connell, Elaine R. Nimmo, John R. B. Perry, Michael R. Stratton, Ralph McGinnis, Pekka Jousilahti, Michiel L. Bots, Ian Jones, Elizabeth Meech, Matthew A. Brown, Johannie Gungadoo, Jian'an Luan, Jilur Ghori, Richard J. Dixon, N. Charlotte Onland-Moret, Fulvio Ricceri, Anthony J. Balmforth, Catherine E. Todhunter, Inês Barroso, Sheila Bingham, Timo T. Valle, Fredrik O. Vannberg, Diana Zelenika, Stephen Sawcer, Anneli Pouta, David M. Evans, Cuno S. P. M. Uiterwaal, Pilar Galan, Georg Homuth, Hannah Donovan, David J. Conway, Paul Elliott, Alessandra Allione, Paul E. de Jong, Miles Parkes, Amy Chaney, John C. Chambers, Toby Johnson, Isaac Subirana, Vesela Gateva, Cathryn M. Lewis, Christopher J. O'Donnell, Hana Lango, David Schlessinger, Mark J. Caulfield, Thorsten Reffelmann, Jamie Barbour, Karen L. Mohlke, Sarah E. Hunt, Thilo Winzer, Frances M K Williams, Christopher Mathew, I. Wallace, Anuj Goel, Jaakko Tuomilehto, Louise V. Wain, Gabriel Crawford, Samantha L. Hider, Detelinea Grozeva, Elaine K. Green, Paul D. Gilbert, Peter S. Braund, Jaume Marrugat, Rainer Rettig, Pim van der Harst, Yik Ying Teo, Andrew P. Morris, Guiseppe Matullo, Serena Sanna, Cristen J. Willer, Suzannah Bumpstead, Niall C. Taylor, Jacques S. Beckmann, Pierre Meneton, Elin Org, Luigi Ferrucci, Doug Easton, Sheila Seal, Joanne M. Heward, Anne U. Jackson, Eleftheria Zeggini, Rachel M. Freathy, Maris Laan, Paul Wordsworth, Sarah Nutland, Kerstin Koch, Sian Ceasar, Anders Hamsten, Judith M. Hussey, Tariq Ahmad, Derek P. Jewell, Paul Scheet, Charlie W. Lees, C Farrar, Christopher Prowse, Markku Laakso, David St Clair, Kate Downes, Diederick E. Grobbee, Paul Burton, Simon C. Potter, Ian N. Bruce, Tim D. Spector, Anne Barton, H.-Erich Wichmann, Matthew J. Simmonds, David Hadley, Cecilia M. Lindgren, Gérard Waeber, Nigel W. Rayner, Melanie J. Newport, Manjinder S. Sandhu, Audrey Duncanson, Guangju Zhai, Simon Heath, Susan M. Ring, Alessandra Di Gregorio, Richard Williamson, Nicholas J. Wareham, Zhan Su, Olle Melander, John R. Thompson, Alexander Teumer, Sheila A. Fisher, Lachlan J. M. Coin, Leif Groop, Giovanni Tognoni, Amanda Elkin, Alan J. Silman, Jack Satsangi, Jane Worthington, Martin Farrall, John Webster, Niall Cardin, Neil Walker, Anna F. Dominiczak, Jeremy D. Sanderson, Damjan Vukcevic, Bryan Howie, Silvia Polidoro, Stephen G. Ball, Mark Tremelling, Stephen Newhouse, Stephen M. Schwartz, Lori L. Bonnycastle, Chris Wallace, Kijoung Song, Mario A. Morken, I. Nicol Ferrier, Beverley Barke, Paolo Vineis, Manuela Uda, Deborah P M Symmons, Emily J. Lyons, Mingzhan Xue, Timothy M. Frayling, Stephen C.L. Cough, David Withers, Adrian V. S. Hill, Suzanne Stevens, Jennifer Jolley, Marcus Dörr, Kirk A. Rockett, David B. Dunger, Mark Walker, Jayne A. Franklyn, Lisa Jones, David S. Siscovick, Ann-Christine Syvänen, Laura J. Scott, Morris J. Brown, Barbera Cant, Michael Inouye, Feng Zhang, Carlotta Sacerdote, Katherine S. Elliott, Jonathan Marchini, Peter Donnely, Michael John Owen, An Goris, Marcus Prembey, Andrew T. Hattersley, Gerome Breen, Marian L. Hamshere, Thomas Illig, Samer S. Najjar, Nicole Soranzo, Kay-Tee Khaw, Graham R. Walters, Willem H. Ouwehand, David P. Strachan, Martin D. Tobin, Alastair Compston, John C. Mansfield, David Altshuler, Salvatore Panico, Sekar Kathiresan, Dawn M. Waterworth, Michael N. Weedon, D. Timothy Bishop, Claire Bryan, Alexandra S. Knight, Kate L. Lee, Paul F. O'Reilly, Massimo Mangino, Michael Conlon O'Donovan, Jing Hua Zhao, Konstantinos A. Papadakis, Jennifer H. Barrett, Joanne Pereira-Gale, N J Timpson, Stephan B. Felix, Panos Deloukas, Nicholas A. Watkins, Anna-Liisa Hartikainen, Peter Vollenweider, Richard Jones, Anne Hinks, Fraser Cummings, Noha Lim, Linda A. Bradbury, Rhian G. William, Nita G. Forouhi, Roberto Eluosa, Ingeleif B. Hallgrimsdottir, Giorgio Sirugo, Robert Luben, Veikko Salomaa, Robert Clarke, Sally John, Ursula Everson, Emma King, Ivan Nikolov, Heather M. Stringham, Antony P. Attwood, Angelo Scuteri
Publikováno v:
Nature Genetics, vol. 41, no. 6, pp. 666-676
Nature Genetics; Vol 41
Nature Genetics, 41(6), 666-676. Nature Publishing Group
Nature Genetics, 41, 666. Nature Publishing Group
Newton-Cheh, C, Johnson, T, Gateva, V, Tobin, M D, Bochud, M, Coin, L, Najjar, S S, Zhao, J H, Heath, S C, Eyheramendy, S, Papadakis, K, Voight, B F, Scott, L J, Zhang, F, Farrall, M, Tanaka, T, Wallace, C, Chambers, J C, Khaw, K-T, Nilsson, P, van der Harst, P, Polidoro, S, Grobbee, D E, Onland-Moret, N C, Bots, M L, Wain, L V, Elliott, K S, Teumer, A, Luan, J, Lucas, G, Kuusisto, J, Burton, P R, Hadley, D, McArdle, W L, Brown, M, Dominiczak, A, Newhouse, S J, Samani, N J, Webster, J, Zeggini, E, Beckmann, J S, Bergmann, S, Lim, N, Song, K, Vollenweider, P, Waeber, G, Waterworth, D M, Yuan, X & Groop, L & Orho-Melander, M 2009, ' Genome-wide association study identifies eight loci associated with blood pressure ', Nature Genetics, vol. 41, no. 6, pp. 666-76 . https://doi.org/10.1038/ng.361
Nature genetics
Nature Genetics
Nature Genetics; Vol 41
Nature Genetics, 41(6), 666-676. Nature Publishing Group
Nature Genetics, 41, 666. Nature Publishing Group
Newton-Cheh, C, Johnson, T, Gateva, V, Tobin, M D, Bochud, M, Coin, L, Najjar, S S, Zhao, J H, Heath, S C, Eyheramendy, S, Papadakis, K, Voight, B F, Scott, L J, Zhang, F, Farrall, M, Tanaka, T, Wallace, C, Chambers, J C, Khaw, K-T, Nilsson, P, van der Harst, P, Polidoro, S, Grobbee, D E, Onland-Moret, N C, Bots, M L, Wain, L V, Elliott, K S, Teumer, A, Luan, J, Lucas, G, Kuusisto, J, Burton, P R, Hadley, D, McArdle, W L, Brown, M, Dominiczak, A, Newhouse, S J, Samani, N J, Webster, J, Zeggini, E, Beckmann, J S, Bergmann, S, Lim, N, Song, K, Vollenweider, P, Waeber, G, Waterworth, D M, Yuan, X & Groop, L & Orho-Melander, M 2009, ' Genome-wide association study identifies eight loci associated with blood pressure ', Nature Genetics, vol. 41, no. 6, pp. 666-76 . https://doi.org/10.1038/ng.361
Nature genetics
Nature Genetics
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c788afaa54ff3f80dee7ce33e23426e
https://hdl.handle.net/11370/ce10605f-7633-4606-bbc8-ecbd9d73092d
https://hdl.handle.net/11370/ce10605f-7633-4606-bbc8-ecbd9d73092d
Autor:
A. G. Uitterlinden, S. Y. Shin, Massimo Mangino, N. Dahmen, Lambertus A. Kiemeney, Dorret I. Boomsma, Arfan Ikram, B.A. Oostra, D. F. Gudbjartsson, Germaine C. Verwoert, Aravinda Chakravarti, Vilmundur Gudnason, Stefan Walter, J. C. Keers, Unnur Thorsteinsdottir, F. J.A. Van Rooij, Henning Tiemeier, Grant W. Montgomery, P. Sulem, Rajesh Rawal, Tim D. Spector, Erich Wichmann, Enda M. Byrne, Nicholas G. Martin, J. C. M. Witteman, Sebastian E. Baumeister, Najaf Amin, Christopher J Hammond, C.M. van Duijn, Astrid Petersmann, Julie Johnson, Aaron Isaacs, Georgia Chenevix-Trench, A. C. J. W. Janssens, Alexander Teumer, J. M. Vink, Ilja M. Nolte, Y S Aulchenko, Angela Doering, Linda Broer, A. C. Heath, B. H.R. Wolfenbuttel, Bruce M. Psaty, Harold Snieder, Fernando Rivadeneira, Kari Stefansson, Albert Hofman, Naomi R. Wray, J. J. Hottenga, Hans-Jörgen Grabe, Rainer Biffar, Daniel Levy
Publikováno v:
Molecular Psychiatry
Molecular Psychiatry, 17(11), 1116-1129. Nature Publishing Group
Amin, N, Byrne, E, Johnson, J, Chenevix-Trench, G, Walter, S, Nolte, I M, Vink, J M, Rawal, R, Mangino, M, Teumer, A, Keers, J C, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N, Doering, A, Isaacs, A, Broer, L, Wray, N R, Montgomery, G W, Levy, D, Psaty, B M, Gudnason, V, Chakravarti, A, Sulem, P, Gudbjartsson, D F, Kiemeney, L A, Thorsteinsdottir, U, Stefansson, K, van Rooij, F J A, Aulchenko, Y S, Rivadeneira, F, Hofman, A, Uitterlinden, A G, Hammond, C J, Shin, S Y, Arfan Ikram, M, Witteman, J C M, Janssens, A C J W, Snieder, H, Tiemeier, H, Wolfenbuttel, B H R, Oostra, B A, Heath, A C, Wichmann, E, Spector, T D, Grabe, H J, Boomsma, D I, Martin, N G & van Duijn, C M 2012, ' Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM ', Molecular Psychiatry, vol. 17, no. 11, pp. 1116-1129 . https://doi.org/10.1038/mp.2011.101
Molecular Psychiatry, 17, 11, pp. 1116-29
Molecular Psychiatry, 17(11), 1116-29. Nature Publishing Group
Molecular Psychiatry, 17, 1116-29
Molecular Psychiatry; Vol 17
Molecular Psychiatry, 17(11), 1116-1129. Nature Publishing Group
Amin, N, Byrne, E, Johnson, J, Chenevix-Trench, G, Walter, S, Nolte, I M, Vink, J M, Rawal, R, Mangino, M, Teumer, A, Keers, J C, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N, Doering, A, Isaacs, A, Broer, L, Wray, N R, Montgomery, G W, Levy, D, Psaty, B M, Gudnason, V, Chakravarti, A, Sulem, P, Gudbjartsson, D F, Kiemeney, L A, Thorsteinsdottir, U, Stefansson, K, van Rooij, F J A, Aulchenko, Y S, Rivadeneira, F, Hofman, A, Uitterlinden, A G, Hammond, C J, Shin, S Y, Arfan Ikram, M, Witteman, J C M, Janssens, A C J W, Snieder, H, Tiemeier, H, Wolfenbuttel, B H R, Oostra, B A, Heath, A C, Wichmann, E, Spector, T D, Grabe, H J, Boomsma, D I, Martin, N G & van Duijn, C M 2012, ' Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM ', Molecular Psychiatry, vol. 17, no. 11, pp. 1116-1129 . https://doi.org/10.1038/mp.2011.101
Molecular Psychiatry, 17, 11, pp. 1116-29
Molecular Psychiatry, 17(11), 1116-29. Nature Publishing Group
Molecular Psychiatry, 17, 1116-29
Molecular Psychiatry; Vol 17
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N = 18 176) and sought replication of our top findings in a further 7929 individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca7ed4e1893bf9da960faac581010b9
https://pubmed.ncbi.nlm.nih.gov/21876539
https://pubmed.ncbi.nlm.nih.gov/21876539
Autor:
Marianne Canonico, Laure Carcaillon, Laurent Becquemont, Elodie Bouaziz, Céline Verstuyft, Pierre-Yves Scarabin, Anne Guiochon-Mantel
Publikováno v:
Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism, 2008, 93 (8), pp.3082-7. ⟨10.1210/jc.2008-0450⟩
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2008, 93 (8), pp.3082-7. ⟨10.1210/jc.2008-0450⟩
Journal of Clinical Endocrinology and Metabolism, 2008, 93 (8), pp.3082-7. ⟨10.1210/jc.2008-0450⟩
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2008, 93 (8), pp.3082-7. ⟨10.1210/jc.2008-0450⟩
International audience; Hormone therapy increases the risk of venous thromboembolism (VTE) among postmenopausal women. This effect may be modulated by the expression of cytochromes P450 3A5 (CYP3A5) and 1A2 (CYP1A2) which are involved in the hepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9253ccb63467fe5991038619a40d70d9
https://pubmed.ncbi.nlm.nih.gov/18628519
https://pubmed.ncbi.nlm.nih.gov/18628519