Heritability of caffeine metabolism:Environmental effects masking genetic effects on CYP1A2 activity but not on NAT2

Autor: Matthaei, Johannes, Tzvetkov, Mladen V, Strube, Jakob, Sehrt, Daniel, Sachse-Seeboth, Cordula, Hjelmborg, Jacob v. B., Möller, Sören, Halekoh, Ulrich, Hofmann, Ute, Schwab, Matthias, Kerb, Reinhold, Brockmöller, Jürgen

Publikováno v: Matthaei, J, Tzvetkov, M V, Strube, J, Sehrt, D, Sachse-Seeboth, C, Hjelmborg, J V B, Möller, S, Halekoh, U, Hofmann, U, Schwab, M, Kerb, R & Brockmöller, J 2016, ' Heritability of caffeine metabolism : Environmental effects masking genetic effects on CYP1A2 activity but not on NAT2 ', Clinical Pharmacology & Therapeutics, vol. 100, no. 6, pp. 606-616 . https://doi.org/10.1002/cpt.444

Heritability of caffeine pharmacokinetics and cytochrome P450 1A2 (CYP1A2) activity is controversial. Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::1ff4e5cd2dd5d73af006082d3f0cada4
https://portal.findresearcher.sdu.dk/da/publications/505827fa-2eef-4b06-a5cf-bf68b63fa2b3

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

Autor: A. G. Uitterlinden, S. Y. Shin, Massimo Mangino, N. Dahmen, Lambertus A. Kiemeney, Dorret I. Boomsma, Arfan Ikram, B.A. Oostra, D. F. Gudbjartsson, Germaine C. Verwoert, Aravinda Chakravarti, Vilmundur Gudnason, Stefan Walter, J. C. Keers, Unnur Thorsteinsdottir, F. J.A. Van Rooij, Henning Tiemeier, Grant W. Montgomery, P. Sulem, Rajesh Rawal, Tim D. Spector, Erich Wichmann, Enda M. Byrne, Nicholas G. Martin, J. C. M. Witteman, Sebastian E. Baumeister, Najaf Amin, Christopher J Hammond, C.M. van Duijn, Astrid Petersmann, Julie Johnson, Aaron Isaacs, Georgia Chenevix-Trench, A. C. J. W. Janssens, Alexander Teumer, J. M. Vink, Ilja M. Nolte, Y S Aulchenko, Angela Doering, Linda Broer, A. C. Heath, B. H.R. Wolfenbuttel, Bruce M. Psaty, Harold Snieder, Fernando Rivadeneira, Kari Stefansson, Albert Hofman, Naomi R. Wray, J. J. Hottenga, Hans-Jörgen Grabe, Rainer Biffar, Daniel Levy

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, 17(11), 1116-1129. Nature Publishing Group
Amin, N, Byrne, E, Johnson, J, Chenevix-Trench, G, Walter, S, Nolte, I M, Vink, J M, Rawal, R, Mangino, M, Teumer, A, Keers, J C, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N, Doering, A, Isaacs, A, Broer, L, Wray, N R, Montgomery, G W, Levy, D, Psaty, B M, Gudnason, V, Chakravarti, A, Sulem, P, Gudbjartsson, D F, Kiemeney, L A, Thorsteinsdottir, U, Stefansson, K, van Rooij, F J A, Aulchenko, Y S, Rivadeneira, F, Hofman, A, Uitterlinden, A G, Hammond, C J, Shin, S Y, Arfan Ikram, M, Witteman, J C M, Janssens, A C J W, Snieder, H, Tiemeier, H, Wolfenbuttel, B H R, Oostra, B A, Heath, A C, Wichmann, E, Spector, T D, Grabe, H J, Boomsma, D I, Martin, N G & van Duijn, C M 2012, ' Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM ', Molecular Psychiatry, vol. 17, no. 11, pp. 1116-1129 . https://doi.org/10.1038/mp.2011.101
Molecular Psychiatry, 17, 11, pp. 1116-29
Molecular Psychiatry, 17(11), 1116-29. Nature Publishing Group
Molecular Psychiatry, 17, 1116-29
Molecular Psychiatry; Vol 17

Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N = 18 176) and sought replication of our top findings in a further 7929 individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca7ed4e1893bf9da960faac581010b9
https://pubmed.ncbi.nlm.nih.gov/21876539