Potential uses of cytisine for smoking cessation in menopausal women – literature summary

Autor: Francisco Rubio Rubio, Fernando Martínez, Maria José Zarzuelo Romero

Publikováno v: Menopause Review, Vol 22, Iss 1, Pp 42-48 (2023)

Externí odkaz: https://doaj.org/article/9c42cb11aa08498bb438f7fbb67ab1a4

A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors

Autor: Timothy Gallagher, Cecilia Gotti, Ana Sofia F Oliveira, Beatriz Elizabeth Nielsen, Richard B. Sessions, Isabel Bermudez, Adrian J. Mulholland, Teresa Minguez-Viñas, Cecilia Bouzat, Deborah K. Shoemark, Susan Wonnacott

Publikováno v: Minguez-Viñas, T, Nielsen, B E, Shoemark, D K, Gotti, C, Sessions, R B, Mulholland, A J, Bouzat, C, Wonnacott, S, Gallagher, T, Bermudez, I & Oliveira, A S 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389
Minguez Viñas, T, Shoemark, D K, Sessions, R B, Mulholland, A J, Gallagher, T, Oliveira, A S & al., E 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389

Background and PurposeThe α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49465823bbfc1af3116cfe62a1b97773
https://doi.org/10.1111/bph.15389

Three (―)-cytisine derivatives and 1-hydroxyquinopimaric acid as acetylcholinesterase inhibitors

Autor: Inna P. Tsypysheva, Radik A. Zaynullin, J. Daniel García-García, Anna Ilyina, E. Patricia Segura-Ceniceros, Alejandra I. Vargas-Segura, R. V. Kunakova, G. F. Vafina

Publikováno v: Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 862-868 (2019)

Graphical abstract
Highlights • Acetylcholinesterase inhibition was studied using four natural compounds derivatives. • Three (―)-cytisine derivatives and 1-hydroxyquinopimaric acid are weak enzyme inhibitors. • Kinetic mechanisms of inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570aef9003fad60d1116c4e9696731e8
https://doi.org/10.1016/j.toxrep.2019.08.011

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