Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Cystic Fibrosis Transmembrane Conductance Regulator/metabolism"'
1
Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis
Autor: Daniel Peckham, Paul Whitaker, Anil Mehta, Sinisa Savic, Michael F. McDermott, T. Scambler, J. Holbrook, Christine Etherington, Ian Clifton, Heledd H. Jarosz-Griffiths, Samuel Lara-Reyna, Giulia Spoletini, C. Wong, Fabio Martinon
Publikováno v: eLife
eLife, Vol 9 (2020)
eLife, vol. 9, pp. e54556
Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulato
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56c3b19820b0ec649de1acb486b5ee6
https://eprints.whiterose.ac.uk/158253/7/elife-54556-v2.pdf
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2
High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine
Autor: Thierry Pedron, Chek Kun Tan, Kalina Duszka, Robert Ducroc, Philippe J. Sansonetti, Céline Mulet, Rémy Burcelin, Azadeh Saffarian, Béatrice Regnault, Walter Wahli, Jean-Baptiste Cavin, Julie Tomas
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (40), pp.E5934-E5943. ⟨10.1073/pnas.1612559113⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (40), ⟨10.1073/pnas.1612559113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (40), ⟨10.1073/pnas.1612559113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (40), pp.E5934-E5943. ⟨10.1073/pnas.1612559113⟩
Proceedings of the National Academy of Sciences of the United States of America 40 (113), E5934-E5943. (2016)
International audience; Diet is among the most important factors contributing to intestinal homeostasis, and basic functions performed by the small intestine need to be tightly preserved to maintain health. Little is known about the direct impact of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d715e572206c92d4584b1dc57bc59c5
https://hal-pasteur.archives-ouvertes.fr/pasteur-02554241
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3
In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis
Autor: Rainer Kiefmann, Lhousseine Touqui, Marie Potier-Cartereau, Christelle Coraux, Cristina Plata, Clémence Henry, Eric Morello, Mustapha Si-Tahar, Antoine Guillon, Emilie Dalloneau, Christophe Vandier, Rose-France Aimar, Maria-Teresa Pérez-Berezo, Frédéric Esnard, Nicolas Cenac, Yongzheng Wu, Miguel A. Valverde, Christian Börnchen
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2016, 311 (3), pp.L664-L675. ⟨10.1152/ajplung.00442.2015⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2016, 311 (3), pp.L664-L675. ⟨10.1152/ajplung.00442.2015⟩
Cystic fibrosis (CF) is an inherited disease associated with chronic severe lung inflammation, leading to premature death. To develop innovative anti-inflammatory treatments, we need to characterize new cellular and molecular components contributing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca96eb875d5e73f302cf82f923967ddb
https://hal.univ-reims.fr/hal-02448649
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4
Src Signaling Links Mediators of Inflammation to Cx43 Gap Junction Channels in Primary and Transformed CFTR-Expressing Airway Cells
Autor: Marc Chanson, Thierry Rochat, Lan Jornot, Jean-Silvain Lacroix, Ludovic Wiszniewski, Susanne Suter, Song Huang
Publikováno v: Cell Communication and Adhesion, Vol. 10, No 4-6 (2003) pp. 279-85
Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) is associated with recurrent pulmonary infections and inflammation. We previously reported that tumor necrosis factor (TNF)-alpha decreases gap junction connectivity in cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b00a874557548d8e57b42d12b8bb95
https://doi.org/10.1080/714040440
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5
Neutrophil Elastase Degrades Cystic Fibrosis Transmembrane Conductance Regulator via Calpains and Disables Channel Function In Vitro and In Vivo
Autor: Emilie Saussereau, Delphine Roussel, Marc Paulais, Pierre Boulanger, Jean-Michel Sallenave, Laurette Malleret, Loïc Guillot, Saw-See Hong, Manon Ruffin, Michel Huerre, Azzaq Belaaouaj, Delphyne Descamps, Aleksander Edelman, Michel Chignard, Mathieu Le Gars, Olivier Tabary
Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2013, 187 (2), pp.170-179. ⟨10.1164/rccm.201205-0875OC⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2013, 187 (2), pp.170-179. ⟨10.1164/rccm.201205-0875OC⟩
Comment in :The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease. [Am J Respir Crit Care Med. 2013]; International audience; RATIONALE:Cystic fibrosis transmembrane conductance regula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d585eceac22851da0d815c97a7fbefd1
https://www.hal.inserm.fr/inserm-02448131
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6
Akademický článek
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7
Critical role of cytosolic phospholipase A2 in bronchial mucus hypersecretion in CFTR-deficient mice
Autor: Lhousseine Touqui, Aarbiou J, Bob J. Scholte, Yongzheng Wu, Y. Kita, Pierre-Régis Burgel, Borot F, Michel Chignard, Ollero M, Clémence Martin, Fariel Dif, Ignacio Garcia-Verdugo, D. Israel-Biet, Dimitri Leduc
Publikováno v: European Respiratory Journal
European Respiratory Journal, 2010, 36 (5), pp.1120-1130. ⟨10.1183/09031936.00183409⟩
European Respiratory Journal, 36(5), 1120-1130. European Respiratory Society
European Respiratory Journal, European Respiratory Society, 2010, 36 (5), pp.1120-1130. ⟨10.1183/09031936.00183409⟩
Cystic fibrosis (CF) is due to mutations in the CF transmembrane conductance regulator gene CFTR. CF is characterised by mucus dehydration, chronic bacterial infection and inflammation, and increased levels of cytosolic phospholipase A2 alpha (cPLA2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ca3cac07312cba69eba555c3cbf17d
https://hal-pasteur.archives-ouvertes.fr/pasteur-02863044
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8
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice
Autor: Ray A. Caldwell, Alessandra Livraghi, Brian Button, Susanne C. Schubert, Bernard C. Rossier, Edith Hummler, Zhe Zhou, Marcus A. Mall, Sylvain Pradervand, Richard C. Boucher, Wanda K. O'Neal, Barbara R. Grubb, Bjarki Johannesson, Carsten Schultz
Publikováno v: Journal of Biological Chemistry, vol. 285, no. 35, pp. 26945-26955
The Journal of Biological Chemistry
Studies in cystic fibrosis patients and mice overexpressing the epithelial Na(+) channel beta-subunit (betaENaC-Tg) suggest that raised airway Na(+) transport and airway surface liquid (ASL) depletion are central to the pathogenesis of cystic fibrosi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baab53229adfb1f253ead965b9cc11d7
https://serval.unil.ch/notice/serval:BIB_44A5A1B88EA4
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10
Long-term cultures of polarized airway epithelial cells from patients with cystic fibrosis
Autor: Lan Jornot, Tecla Dudez, Jean Silvain Lacroix, Thierry Rochat, Marc Chanson, Ludovic Wiszniewski, Susanne Suter, Alessandra Pagano
Publikováno v: American Journal of Respiratory Cell and Molecular Biology, Vol. 34, No 1 (2006) pp. 39-48
The poor ability of respiratory epithelial cells to proliferate and differentiate in vitro into a pseudostratified mucociliated epithelium limits the general use of primary airway epithelial cell (AEC) cultures generated from patients with rare disea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e6dcee536722e86c961f32f809c148
https://archive-ouverte.unige.ch/unige:27057
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