Zobrazeno 1 - 10
of 10 478
pro vyhledávání: '"Cysteine-protease"'
Autor:
Kumar Sushil, Joshi Nidhi, Choudhir Gourav, Sharma Sakshi, Tiwari Abhay, Alharbi Sulaiman Ali, Alfarraj Saleh, Ansari Mohammad Javed
Publikováno v:
Polish Journal of Microbiology, Vol 73, Iss 2, Pp 207-215 (2024)
Chikungunya virus (CHIKV) causes a debilitating fever and joint pain, with no specific antiviral treatment available. Halogenated secondary metabolites from plants are a promising new class of drug candidates against chikungunya, with unique properti
Externí odkaz:
https://doaj.org/article/3920a525a29146fdb57c9decc5c8e392
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100107- (2024)
Clostripain secreted from Clostridium histolyticum is the founding member of the C11 family of Clan CD cysteine peptidases, which is an important group of peptidases secreted by numerous bacteria. Clostripain is an arginine-specific endopeptidase. Be
Externí odkaz:
https://doaj.org/article/f8ebe8552c8544a8b6e77f0a351d2084
Autor:
Yuzhi Wu, Hongyu Gao, Haidong Yu, Xiaoli Wang, Huihui Li, Qiwang Jin, Xinguang Zhu, Qianqian Li, Nuocheng Kong, Yifan Tang, Shuo Han, Xinlong Xu, Bin Zhan, Fang Li, Xiaodi Yang, Qiang Wu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 281, Iss , Pp 116615- (2024)
Background: Paraquat (PQ) is a widely used herbicide that poisons human by accident or intentional ingestion. PQ poisoning causes systemic inflammatory response syndrome (SIRS) resulting in acute lung injury (ALI) with an extremely high mortality rat
Externí odkaz:
https://doaj.org/article/bf8a8daa3e724fc0840770877c4b96ef
Publikováno v:
Iranian Journal of Parasitology, Vol 19, Iss 2 (2024)
Background: Iranian Lizard Leishmania (I.L.L) is a nonpathogenic Leishmania strain. Due to its advantages, several recombinant proteins have been produced in this host. However, I.L.L shows a lower yield of recombinant protein expression compared to
Externí odkaz:
https://doaj.org/article/a4af028573ba48d4b6191b41beab9e82
Autor:
Igor A. Schepetkin, Andreas M. Fischer
Publikováno v:
Plants, Vol 13, Iss 21, p 3009 (2024)
Leaf senescence is a developmental process allowing nutrient remobilization to sink organs. Previously cysteine proteases have been found to be highly expressed during leaf senescence in different plant species. Using biochemical and immunoblotting a
Externí odkaz:
https://doaj.org/article/3cd647d6bc2f4b1291aec4d824ddc8b5
Publikováno v:
Pathogens, Vol 13, Iss 10, p 825 (2024)
SARS-CoV-2 is a spherical, positive-sense, single-stranded RNA virus with a large genome, responsible for encoding both structural proteins, vital for the viral particle’s architecture, and non-structural proteins, critical for the virus’s replic
Externí odkaz:
https://doaj.org/article/103f86bb950f450286e41f589813fea5
Autor:
Anirban Ghoshal, Álvaro F. Magalhães, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew H. Todd, Timothy M. Willson
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 836 (2024)
Optimized syntheses of (E)-5-(2-ethoxyphenyl)-N-(3-(methylsulfonyl)allyl)-1H-pyrazole-3-carboxamide (RA-0002034, 1), a promising antiviral covalent cysteine protease inhibitor lead, were developed. The syntheses avoid the contamination of 1 with the
Externí odkaz:
https://doaj.org/article/87f8f130ef43418e9874a8e9b8ca2984
Autor:
Ling Shi, Qing Xiong, Fu Kiu Ao, Tsz Yau Wan, Xiaojun Xiao, Xiaoyu Liu, Baoqing Sun, Anchalee Tungtrongchitr, Ting Fan Leung, Stephen Kwok Wing Tsui
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Background Astigmatic mites contain potent allergens that can trigger IgE‐mediated immune responses, leading to allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. In house dust mites Dermatophagoides pteronyssinus a
Externí odkaz:
https://doaj.org/article/a4aa6fe1f876421b8d990ee549a1b617
Autor:
Bei Wang, Hai-jun Li, Mi-mi Cai, Zhao-xin Lin, Xia-fei Ou, Shu-hua Wu, Rui-huan Cai, Ying-na Wei, Fei Yang, Ya-min Zhu, Zi-feng Yang, Nan-shan Zhong, Ling Lin
Publikováno v:
EClinicalMedicine, Vol 63, Iss , Pp 102189- (2023)
Summary: Background: This study aimed to evaluate the efficacy and safety of RAY1216, a novel inhibitor of 3-chymotrypsin-like cysteine protease (3CLpro), in adults with coronavirus disease 2019 (COVID-19). Methods: This phase 2, single centre, rando
Externí odkaz:
https://doaj.org/article/3550d7e9de2140a88c936584b6e4d51e