Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cyrus Takahashi"'
Autor:
Brandt C. Huddle, Bo Wen, Cameron D. Buchman, Bikash Debnath, Mikhail Chtcherbinine, Jeremy Felton, Cyrus Takahashi, Edward Grimley, Ronald J. Buckanovich, Scott D. Larsen, Stacy McGonigal, Nouri Neamati, Duxin Sun, Thomas D. Hurley, Shu Pan, Siwei Li, Shuai Mao
Publikováno v:
Eur J Med Chem
There is strong evidence that inhibition of one or more Aldehyde Dehydrogenase 1A (ALDH1A) isoforms may be beneficial in chemotherapy-resistant ovarian cancer and other tumor types. While many previous efforts have focused on development of ALDH1A1 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547d607c7e64542a6c0f897fe2c17150
https://pubmed.ncbi.nlm.nih.gov/33341649
https://pubmed.ncbi.nlm.nih.gov/33341649
Publikováno v:
The Journal of Organic Chemistry. 80:1349-1356
Due to its inherent reactivity, HNO must be generated in situ through the use of donor compounds. One of the primary strategies for the development of new HNO donors has been modifying hydroxylamines with good leaving groups. A recent example of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbd0b6fe37a54790c7835c216169c2c
https://doi.org/10.1021/jo5023316
https://doi.org/10.1021/jo5023316
Autor:
Genaro A. Ramirez-Correa, David A. Kass, Guangshuo Zhu, Pingbo Zhang, Gizem Keceli, Amir S. Heravi, Anne M. Murphy, Nazli Okumus, Cyrus Takahashi, Yuejin Li, Nazareno Paolocci
Background: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82485bf350c43058f73a33f010b21595
http://hdl.handle.net/11577/3289382
http://hdl.handle.net/11577/3289382
Autor:
Yuejin Li, Guangshuo Zhu, Cyrus Takahashi, Djahida Bedja, Genaro Ramirez-Correa, Nazareno Paolocci, David A Kass, Anne M Murphy
Publikováno v:
Circulation. 132
Background: Phosphorylation of cardiac troponin I (cTnI) on Ser199 is significantly increased in human heart failure (HF), however its cardiac impact in vivo remains unknown. In addition, selective proteolysis of cTnI is a marker of myocardial injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16afd9f25cfc5e4f38006f93146339e4
https://doi.org/10.1161/circ.132.suppl_3.15554
https://doi.org/10.1161/circ.132.suppl_3.15554
Autor:
Cyrus Takahashi, Daryl A. Guthrie, John P. Toscano, Matthew J. Morris, Anthony Collins, Anthony Ho
Publikováno v:
The Journal of organic chemistry. 80(3)
A new and versatile class of HNO donors, the (hydroxylamino)pyrazolone (HAPY) series of HNO donors utilizing pyrazolone (PY) leaving groups, is described. HNO, the smallest N-based aldehyde equivalent, is used as a reagent along with a variety of PY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf586abdef2d66a9b304f09079045e49
https://pubmed.ncbi.nlm.nih.gov/25594416
https://pubmed.ncbi.nlm.nih.gov/25594416
Autor:
Nazareno Paolocci, Cyrus Takahashi, Pooja Jagadish, John P. Toscano, Ashwin Jagadish, Donald B. Hoover
Publikováno v:
Biophysical Journal. 108(2)
Selective alpha7 nicotinic receptor agonists, such as GTS-21, are known to have neuroprotective and anti-inflammatory actions, but the effect of these agents on the heart is not known. Therefore, we evaluated the actions of GTS-21 in isolated atria a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5fd79cb1a3bffb91f4c5e086639c02
Autor:
Carlo G. Tocchetti, Cyrus Takahashi, Gordon F. Tomaselli, David A. Kass, Takeshi Aiba, Sabine Huke, Nazareno Paolocci, Guangshuo Zhu, Ning Feng, Donald M. Bers
Publikováno v:
Autonomic Neuroscience. 192:51-52
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd034364803e4bc0eb3f9a2a05a3edd3
https://doi.org/10.1016/j.autneu.2015.07.413
https://doi.org/10.1016/j.autneu.2015.07.413