Výsledky vyhledávání - "Cyrus M Ghajar"

Akademický článek

Defining cellular population dynamics at single-cell resolution during prostate cancer progression

Publikováno v: eLife, Vol 11 (2022)

Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate prostate cancer cell dynamics at single-cell resolution f

Externí odkaz: https://doaj.org/article/df92bed0fdd1409a988b59a78b4ffbca

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Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele

Autor: Candice A. Grzelak, Cyrus M. Ghajar

Publikováno v: ImmunoHorizons. 7:64-70

The human ubiquitin C promoter (UBC)–driven GFP-transgenic mouse (UBC-GFP) transgene integration site was mapped recently to chromosome 17, linked closely to the MHC locus. In this study, we demonstrate a functional consequence of this insertion si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ccaaf9c7176043cf8ba63e9621cf00d
https://doi.org/10.4049/immunohorizons.2200101

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Metastasis

Autor: David Lyden, Cyrus M. Ghajar, Ana Luísa Correia, Julio A. Aguirre-Ghiso, Shang Cai, Maria Rescigno, Peiyuan Zhang, Guohong Hu, Sarah-Maria Fendt, Adrienne Boire, Ralph R. Weichselbaum, Rohan R. Katipally

Publikováno v: Cancer Cell

Metastasis, the major cause of cancer death, represents one of the major challenges in oncology. Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dorm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbac350bc3d9aecf36ca4120e3b50eed
https://doi.org/10.1016/j.ccell.2022.07.010

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Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain

Publikováno v: Nature Cancer. 3:25-42

Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell (DTC) dormancy in this organ is limited. Here using serial intravital i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1a8b0fd407d8da58871036eb79423e
https://doi.org/10.1038/s43018-021-00297-3

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The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings

Autor: David Lyden, Laura Pisarsky, Cyrus M. Ghajar, Irina Matei, Sun-Young Lee, Serena Lucotti, Mina J. Bissell, Jinxiang Dai, Ryann E Shor

Publikováno v: Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 130-147 (2022)

Dormant, disseminated tumor cells (DTCs) are thought to be the source of breast cancer metastases several years or even decades after initial treatment. To date, a selective therapy that leads to their elimination has not been discovered. While dorma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6e9d695bd3f27a618d4ca4d8d16ada
https://doi.org/10.1002/1878-0261.13031

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When a House Is Not a Home: A Survey of Antimetastatic Niches and Potential Mechanisms of Disseminated Tumor Cell Suppression

Autor: Sarah B Crist, Cyrus M. Ghajar

Publikováno v: Annual Review of Pathology: Mechanisms of Disease. 16:409-432

Over the last four decades, the cancer biology field has concentrated on cellular and microenvironmental drivers of metastasis. Despite this focus, mortality rates upon diagnosis of metastatic disease remain essentially unchanged. Would a small chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190286548decf09bccb6874aba4bdf0c
https://doi.org/10.1146/annurev-pathmechdis-012419-032647

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