FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Autor: Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am deme

Externí odkaz: https://doaj.org/article/9446244d632a4b05a389d98461a70dd7

METTL3 regulates breast cancer-associated alternative splicing switches

Autor: Cyrinne Achour, Paula Groza, Devi Prasad Bhattarai, Ángel-Carlos Román, Francesca Aguilo

Alternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play major roles in the development of different pathologies, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59434c3a6fe8b235d3f1c31295ea93f0
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194175

tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila

Autor: Jean-Yves Roignant, Margarita T Angelova, Vincent Guérineau, Caroline Jacquier, Clément Carré, Bruno Da Silva, Christophe Antoniewski, Matthias Schaefer, Souraya Khouider, Mira Brazane, Yuri Motorin, Salman Shehzada, Damien Brégeon, Tina Lence, Virginie Marchand, Valérie Bourguignon-Igel, Dilyana G. Dimitrova, Cyrinne Achour, Catherine Goyenvalle, Laure Teysset

Publikováno v: Nucleic acids research, vol. 48, no. 4, pp. 2050-2072
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (4), pp.2050-2072. ⟨10.1093/nar/gkaa002⟩
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa002⟩

2′-O-Methylation (Nm) represents one of the most common RNA modifications. Nm affects RNA structure and function with crucial roles in various RNA-mediated processes ranging from RNA silencing, translation, self versus non-self recognition to viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3016f881fc9b48b02b58bc910d26df8c
https://serval.unil.ch/resource/serval:BIB_54F1E8540412.P001/REF.pdf

Long Noncoding RNAs as Players in Breast Tumorigenesis

Autor: Francesca Aguilo, Cyrinne Achour

Publikováno v: RNA Technologies ISBN: 9783030447427

Comprehensive analysis of the mammalian genome uncovered the discovery of pervasive transcription of large RNA transcripts that do not code for proteins, namely, long noncoding RNAs (lncRNAs). LncRNAs play important roles in the regulation of gene ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b115abc936037faf6e257cb349c957
https://doi.org/10.1007/978-3-030-44743-4_15

tRNA 2’-O-methylation modulates small RNA silencing and life span in Drosophila

Autor: Matthias Schaefer, Margarita T Angelova, Caroline Jacquier, Valérie Bourguignon-Igel, Tina Lence, Yuri Motorin, Vincent Guérineau, Damien Brégeon, Virginie Marchand, Dilyana G. Dimitrova, Clément Carré, Bruno Da Silva, Cyrinne Achour, Christophe Antoniewski, Salman Shehzada, Catherine Goyenvalle, Laure Teysset, Jean-Yves Roignant

2’-O-methylation (Nm) represents one of the most common RNA modifications. Nm affects RNA structure and function with crucial roles in various RNA-mediated processes ranging from RNA silencing, translation, self versus non-self recognition to viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84defc3de4fdb131627671eb80da914
https://doi.org/10.1101/699934