Výsledky vyhledávání - "Cyrine Ezzili"

One-Year Toxicity Report of the RADIOPARP Phase I Trial Evaluating Olaparib With Radiotherapy for Triple Negative Breast Cancer

Autor: Francesco Ricci, Souhir Neffati, Cyrine Ezzili, L. Bazire, Laurence Raizonville, Fatima Laki, Pierre Loap, Alain Fourquet, K.I. Cao, Véronique Mosseri, J-Y Pierga, Y.M. Kirova, Anne Vincent-Salomon, Delphine Loirat, M. Ezzalfani, Frédérique Berger, Manuel Rodrigues

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 111:S8

Purpose/Objective(s) Preclinical studies have found that triple-negative breast cancer (TNBC) cells were sensitive to PARP1 inhibitors. The phase I dose-escalation RADIOPARP trial evaluated in TNBC patients the combination of breast radiotherapy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::036d6a5a2456eb73d181b52aa9002864
https://doi.org/10.1016/j.ijrobp.2021.07.052

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Abstract OT2-03-01: A phase one trial of olaparib with radiation therapy in patients with triple negative breast cancer: RADIOPARP

Autor: Souhir Neffati, Jean-Yves Pierga, M. Ezzalfani, Véronique Mosseri, Frédérique Berger, Fatima Laki, Youlia M. Kirova, Alain Fourquet, Francesco Ricci, Marie Paule Sablin, Cyrine Ezzili, L. Bazire, Delphine Loirat, A. Chilles, Laurence Raizoville, Manuel Rodrigues, Claire Bertrand, Anne Vincent Salomon

Publikováno v: Cancer Research. 80:OT2-03

Background Preclinical studies have shown that breast cancer (BC) cell lines with a triple-negative phenotype are more sensitive to PARP1 inhibitors compared with non-TNBC cells. All these lines of evidence provide a strong rationale for developing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd9558a68e1d40e32f018e7791b53fba
https://doi.org/10.1158/1538-7445.sabcs19-ot2-03-01

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The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice

Autor: Jacqueline L. Blankman, Dale L. Boger, Steven G. Kinsey, Aron H. Lichtman, Benjamin F. Cravatt, Rehab A. Abdullah, Lamont Booker, Jonathan Z. Long, Cyrine Ezzili

Publikováno v: British Journal of Pharmacology. 165:2485-2496

BACKGROUND AND PURPOSE Inflammatory pain presents a problem of clinical relevance and often elicits allodynia, a condition in which non-noxious stimuli are perceived as painful. One potential target to treat inflammatory pain is the endogenous cannab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56a1387ad35206382a546585cf7de12f
https://doi.org/10.1111/j.1476-5381.2011.01445.x

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Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase

Autor: Benjamin F. Cravatt, Raymond C. Stevens, Mauro Mileni, Joie Garfunkle, Cyrine Ezzili, Dale L. Boger

Publikováno v: Journal of the American Chemical Society. 133:4092-4100

Two cocrystal X-ray structures of the exceptionally potent α-ketoheterocycle inhibitor 1 (Ki = 290 pM) bound to a humanized variant of rat fatty acid amide hydrolase (FAAH) are disclosed, representing noncovalently and covalently bound states of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f578047f7f85a6795907ba56ea965a5
https://doi.org/10.1021/ja110877y

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X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Autor: Raymond C. Stevens, F. Scott Kimball, Cyrine Ezzili, Dale L. Boger, Benjamin F. Cravatt, Joie Garfunkle, Mauro Mileni

Publikováno v: Journal of Medicinal Chemistry. 53:230-240

Three cocrystal X-ray structures of the alpha-ketoheterocycle inhibitors 3-5 bound to a humanized variant of fatty acid amide hydrolase (FAAH) are disclosed and comparatively discussed alongside those of 1 (OL-135) and its isomer 2. These five X-ray

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf0fff7f9f9550f715bd1a4feec20db
https://doi.org/10.1021/jm9012196

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Clinical study of the novel cyclin-dependent kinase inhibitor dinaciclib in combination with rituximab in relapsed/refractory chronic lymphocytic leukemia patients

Autor: Christophe Le Tourneau, Karen Small, Marie Paule Sablin, Marco Gobbi, Da Zhang, Cyrine Ezzili, Claire Fabre, Honghong Zhou, Ellie Im, Nabeegha Shinwari, Mustapha Zoubir

Dinaciclib is a novel selective inhibitor of cyclin-dependent kinase (CDK)1, CDK2, CDK5, and CDK9. We conducted a phase I study to investigate the effects of dinaciclib when administered with rituximab. In this phase I nonrandomized dose-escalation 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d4813beda403d9d13d1afb926f5240
http://hdl.handle.net/11567/783410

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The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice

Autor: Lamont, Booker, Steven G, Kinsey, Rehab A, Abdullah, Jacqueline L, Blankman, Jonathan Z, Long, Cyrine, Ezzili, Dale L, Boger, Benjamin F, Cravatt, Aron H, Lichtman

Publikováno v: British journal of pharmacology. 165(8)

Inflammatory pain presents a problem of clinical relevance and often elicits allodynia, a condition in which non-noxious stimuli are perceived as painful. One potential target to treat inflammatory pain is the endogenous cannabinoid (endocannabinoid)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfc0bd564372a7b981675c16bf020e77
https://pubmed.ncbi.nlm.nih.gov/21506952

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