Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cyrille Lescop"'
Publikováno v:
Organic Process Research & Development. 20:1637-1646
A practical synthesis of S1P receptor 1 agonist ACT-334441 (1) through late-stage convergent coupling of two key intermediates is described. The first intermediate is 2-cyclopentyl-6-methoxyisonicotinic acid whose skeleton was built from 1-cyclopenty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::349604b7321fb9fdca8610af8d5e867b
https://doi.org/10.1021/acs.oprd.6b00210
https://doi.org/10.1021/acs.oprd.6b00210
Autor:
Thomas Weller, Martin Bolli, Claus Müller, Ruben de Kanter, Markus Rey, Magdalena Birker, Patrick Sieber, Cyrille Lescop, Christopher Kohl, Boris Mathys, Beat Steiner, Patrick Hess, Oliver Nayler
Publikováno v:
European Journal of Medicinal Chemistry. 116:222-238
In a previous communication we reported on the discovery of alkylamino pyridine derivatives (e.g. 1) as a new class of potent, selective and efficacious S1P1 receptor (S1PR1) agonists. However, more detailed profiling revealed that this compound clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc8392021bea5d4bf4ef196324d4ad8
https://doi.org/10.1016/j.ejmech.2016.03.048
https://doi.org/10.1016/j.ejmech.2016.03.048
Autor:
Magdalena Birker, Jörg Velker, Patrick Hess, Ruben de Kanter, Oliver Nayler, Markus Rey, Beat Steiner, Martin Bolli, Patrick Sieber, Christopher Kohl, Cyrille Lescop, Thomas Weller
Publikováno v:
European Journal of Medicinal Chemistry. 115:326-341
In a previous communication we reported on the discovery of aminopyridine 1 as a potent, selective and orally active S1P1 receptor agonist. More detailed studies revealed that this compound is phototoxic in vitro. As a result of efforts aiming at eli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efce13dfcace03905e7c2c4dd907002
https://doi.org/10.1016/j.ejmech.2016.03.020
https://doi.org/10.1016/j.ejmech.2016.03.020
Autor:
Luca, Piali, Magdalena, Birker-Robaczewska, Cyrille, Lescop, Sylvie, Froidevaux, Nicole, Schmitz, Keith, Morrison, Christopher, Kohl, Markus, Rey, Rolf, Studer, Enrico, Vezzali, Patrick, Hess, Martine, Clozel, Beat, Steiner, Martin H, Bolli, Oliver, Nayler
Publikováno v:
Pharmacology Research & Perspectives
Sphingosine‐1‐phosphate receptor 1 (S1P1) modulators sequester circulating lymphocytes within lymph nodes, thereby preventing potentially pathogenic autoimmune cells from exiting into the blood stream and reaching inflamed tissues. S1P1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0454bce66af04dd6f9e57d2364b830fd
https://pubmed.ncbi.nlm.nih.gov/29226621
https://pubmed.ncbi.nlm.nih.gov/29226621
Autor:
Magdalena, Birker-Robaczewska, Martin, Bolli, Markus, Rey, Ruben, de Kanter, Christopher, Kohl, Cyrille, Lescop, Maxime, Boucher, Sylvie, Poirey, Beat, Steiner, Oliver, Nayler
Publikováno v:
Molecular pharmacology. 93(2)
S1P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b671900af2fa15fbf7b38d13edffd957
https://pubmed.ncbi.nlm.nih.gov/29203519
https://pubmed.ncbi.nlm.nih.gov/29203519
Autor:
Beat Steiner, Martin Bolli, Sylvie Froidevaux, Magdalena Birker-Robaczewska, Christopher Kohl, Keith Morrison, Markus Rey, Rolf Studer, Luca Piali, Patrick Hess, Nicole Schmitz, Enrico Vezzali, Oliver Nayler, Martine Clozel, Cyrille Lescop
Publikováno v:
Pharmacology Research & Perspectives. 5:e00370
Sphingosine-1-phosphate receptor 1 (S1P1 ) modulators sequester circulating lymphocytes within lymph nodes, thereby preventing potentially pathogenic autoimmune cells from exiting into the blood stream and reaching inflamed tissues. S1P1 receptor mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625e01f90cf17442bb6bcdb45f31a7ed
https://doi.org/10.1002/prp2.370
https://doi.org/10.1002/prp2.370
Publikováno v:
European Journal of Organic Chemistry. 2006:5207-5218
Cyclobutene compounds are interesting intermediates that have proven to be useful in organic synthesis. This review mainly deals with preparations and reactions of some cyclobutenes disubstituted at the allylic position. Several possibilities in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf410a5815e00ca3a632813d844b9de
https://doi.org/10.1002/ejoc.200600406
https://doi.org/10.1002/ejoc.200600406
Autor:
Cyrille Lescop, Philip Magnus
Publikováno v:
Tetrahedron Letters. 42:7193-7196
Irradiation of the macrolactam 15 results in a photo-Fries rearrangement to give the complete diazonamide core skeleton 16 in good yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64aa444998029211c785eb00d555944c
https://doi.org/10.1016/s0040-4039(01)01515-5
https://doi.org/10.1016/s0040-4039(01)01515-5
Autor:
Cyrille Lescop, François Huet
Publikováno v:
Tetrahedron. 56:2995-3003
The two diastereomers of a 3-oxabicyclo[3.1.0]hexan-2-ol 21a – b with the cyclopropane ring substituted by a hydroxymethyl group were synthesized from both products 17a and 18a obtained from the bromohydroxylation of epoxide 16a derived from 3-oxab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5e464708a5052d33a57c0db0bf86f95
https://doi.org/10.1016/s0040-4020(00)00174-5
https://doi.org/10.1016/s0040-4020(00)00174-5
Publikováno v:
Tetrahedron Letters. 41:3057-3060
Stereoselective rearrangement of 6,7-epoxy-3-oxabicyclo[3.2.0]heptan-2-ones 2 and 3 in water afforded a cis-fused butyrolactone as a mixture of two epimers 1a–b. These were used as the starting materials to prepare new bicyclonucleosides 8a–b.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d577cbca4ca09a9937e60a90330bb3ff
https://doi.org/10.1016/s0040-4039(00)00334-8
https://doi.org/10.1016/s0040-4039(00)00334-8