Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Cyrille, Kuhn"'
Autor:
Thao Trinh, James Gillard, Clint James, Martin Duplessis, Laibin Luo, Michael Franti, Carl Thibeault, Marc-André Joly, Jessica Desjardins, Martine Brault, Claudio Sturino, Montse Llinas-Brunet, Sébastien Morin, Sonia Tremblay, Mathieu Parisien, Louie Lamorte, Josée Bordeleau, Cyrille Kuhn, François Bilodeau, Maude Poirier, Sanjay Srivastava, Christiane Yoakim, Nathalie Dansereau, James L. Gleason, Lee Fader, Vida Gorys, Louis Morency
Publikováno v:
ACS Medicinal Chemistry Letters. 7:525-530
A high-throughput screen based on a viral replication assay was used to identify inhibitors of the human cytomegalovirus. Using this approach, hit compound 1 was identified as a 4 μM inhibitor of HCMV that was specific and selective over other herpe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee1e021d799cff1bd9fa128c1ad3428
https://doi.org/10.1021/acsmedchemlett.6b00064
https://doi.org/10.1021/acsmedchemlett.6b00064
Autor:
Hu Liu, Cyrille Kuhn, Rahul Sharma, Natasha M. Kablaoui, Gordon Alton, Miret Juan, Brendan Connolly, Robert V. Stanton, Ping Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:849-852
S6K1 (p70 S6 kinase-1) is thought to play a critical role in the development of obesity and insulin resistance, thus making it an attractive target in developing medicines for the treatment of these disorders. We describe a novel thiophene urea class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f88b0b52f1603ace77ae3414728ef2c
https://doi.org/10.1016/j.bmcl.2010.11.069
https://doi.org/10.1016/j.bmcl.2010.11.069
Autor:
Theresa L. Johnson, Steven Kazmirski, Simon Low, Cyrille Kuhn, Robert V. Stanton, Yuan-Hua Ding, Gayatri D. Deshmukh, Jessie M. English, Haile Tecle, Glen Rennie, Ping Ye, Hu Liu, Joseph Wu, Alan C. Cheng, Suzanne L. Jacques, Rocco Coli, Frederic Feru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4885-4891
By targeting an extended region of the conventional 'DFG-out' pocket of p38alpha, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able to design and synthesize a number of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cbf5efbbf3041f28125e01eba59d8c
https://doi.org/10.1016/j.bmcl.2010.06.073
https://doi.org/10.1016/j.bmcl.2010.06.073
Autor:
Darcy Kohls, Simon Low, Glen Rennie, Yuan-Hua Ding, Cyrille Kuhn, Frederic Feru, Michael Kothe, Rocco Coli
Publikováno v:
Chemical Biology & Drug Design. 70:540-546
Polo-like kinase 1 is an important regulator of cell cycle progression whose over-expression is often associated with oncogenesis. Polo-like kinase 1 hence represents an attractive target for cancer intervention. BI 2536 (Boehringer Ingelheim, Ingelh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f56f22404ef9e96e6c481d195548de
https://doi.org/10.1111/j.1747-0285.2007.00594.x
https://doi.org/10.1111/j.1747-0285.2007.00594.x
Autor:
Jiansu Zhang, Cyrille Kuhn, Paul Bauer, Laurence Philippe, Juan Miret, Marc Bazin, Laurie Tylaska
Publikováno v:
Chemical Biology & Drug Design. 70:268-272
A cell-based assay for the chemokine G-protein-coupled receptor CCR4 was developed, and used to screen a small-molecule compound collection in a multiplex format. A series of bipiperidinyl carboxylic acid amides amenable to parallel chemistry were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45ebd0252996872f0ddcdf8f439646b
https://doi.org/10.1111/j.1747-0285.2007.00551.x
https://doi.org/10.1111/j.1747-0285.2007.00551.x
Autor:
Simon Low, Rocco Coli, Yuan-Hua Ding, Alan C. Cheng, Alissa L. Sheils, Cyrille Kuhn, Thomas A. Wynn, Theresa L. Johnson, Jim Nonomiya, Suzanne L. Jacques, Darcy Kohls, Cristina Lewis, Michael Kothe, Kimberly A. Verdries, Christine Loh
Publikováno v:
Biochemistry. 46:5960-5971
Polo-like kinase 1 (Plk1) is an attractive target for the development of anticancer agents due to its importance in regulating cell-cycle progression. Overexpression of Plk1 has been detected in a variety of cancers, and expression levels often corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb7b5150b3f78f35926d557efc4acae
https://doi.org/10.1021/bi602474j
https://doi.org/10.1021/bi602474j
Publikováno v:
European Journal of Organic Chemistry. 2003:2585-2595
A study on the enantioselective synthesis of 4-alkyl-4-hydroxyalkylidene-cyclopentenone prostaglandins is reported. Two (3+2) annulation processes allow the synthesis of homochiral 4-alkyl-4-hydroxy-2-cyclopentenones 4−5, 10−11, and 17. The first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d90055e537bf8b343f4829b08e8925
https://doi.org/10.1002/ejoc.200300045
https://doi.org/10.1002/ejoc.200300045
Publikováno v:
The Journal of Organic Chemistry. 67:526-532
Supported P4-t-Bu enolate chemistry of phenylacetyloxymethyl polystyrene (PS) resin was investigated using high-resolution magic angle spinning (HR-MAS) NMR spectroscopy. Direct analysis of the crude reaction suspensions through the use of a diffusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9c096af137173c75d99d0712a771e7
https://doi.org/10.1021/jo0161633
https://doi.org/10.1021/jo0161633
Autor:
David G. Perregaux, Perry S. Sawyer, Mark Edward Flanagan, Michael John Munchhof, Kelly S. Magnuson, Jonathan L. Doty, Craig R. Kent, Paul S. Changelian, Thomas M. Harris, Jianmin Sun, David A. Whipple, Cyrille Kuhn, Kudlacz Elizabeth M, Deborah J. Moshinsky
Publikováno v:
Blood. 111:2155-2157
PF-956980 is a selective inhibitor of JAK3, related in structure to CP-690550, a compound being evaluated in clinical trials for rheumatoid arthritis and prevention of allograft rejection. PF-956980 has been evaluated against a panel of 30 kinases, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f2de0ea859bf3e0d4c38ae35781418
https://doi.org/10.1182/blood-2007-09-115030
https://doi.org/10.1182/blood-2007-09-115030
Autor:
Cyrille Kuhn, J.‐C. Florent
Publikováno v:
Tetrahedron Letters. 39:4247-4250
An efficient and stereoselective synthesis of a chiral precursor of 2-chloro-4-hydroxy-4-alkyl-2-cyclopentenone has been realized by alkylation of a sugar methyl uronate derived from 1, 2-O-isopropylidene α-D-glucose with an acetonyl equivalent, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aaa8c1ef0978b94039d16f8b75601fd
https://doi.org/10.1016/s0040-4039(98)00694-7
https://doi.org/10.1016/s0040-4039(98)00694-7