Prediction of the carcinogenic potential of human pharmaceuticals using repeated dose toxicity data and their pharmacological properties

Autor: Jan Willem Van Der Laan, Wenny Buitenhuis, Laura Wagenaar, Ans Soffers, Eugene van Someren, Cyrille Krul, Ruud Woutersen

Publikováno v: Frontiers in Medicine, Vol 3 (2016)

In an exercise designed to reduce animal use, we analysed the results of rat sub-chronic toxicity studies from 289 pharmaceutical compounds with the aim to predict the tumour outcome of carcinogenicity studies in this species. The results were obtain

Externí odkaz: https://doaj.org/article/d2a51666cf6d46ac9e73565fb53125b4

Een praktische gids voor probiotica ter preventie van antibiotica-gerelateerde diarree in Nederland

Autor: Valeria Agamennone, Cyrille Krul, Ger Rijkers, Remco Kort

Publikováno v: Agamennone, V, Krul, C, Rijkers, G & Kort, R 2019, ' Een praktische gids voor probiotica ter preventie van antibiotica-gerelateerde diarree in Nederland ', Pharmaceutisch Weekblad, vol. 154, no. 6, pp. 17-24 . < https://www.npfo.nl/artikel/een-praktische-gids-voor-probiotica-ter-preventie-van-antibiotica-gerelateerde-diarree-nederland >
Vrije Universiteit Amsterdam
Pharmaceutisch Weekblad, 154(6), 17-24. Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP)

BACKGROUND Antibiotic-associated diarrhea (AAD) is a side-effect frequently associated with the use of broad spectrum antibiotics. Although a number of clinical studies show that co-administration of specific probiotics reduces the risk for AAD, ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2eafb40fd1bf20760d79f231a25f34d5
https://research.vu.nl/en/publications/6dccb024-dc56-405c-ade7-74a43c7bfd4d

A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands

Autor: Valeria Agamennone, Cyrille Krul, Ger T. Rijkers, Remco Kort

Publikováno v: Bmc Gastroenterology, 18:103, 1-12. BioMed Central
BMC Gastroenterol., 18(1), 103-103
BMC Gastroenterology
Agamennone, V, Krul, C A M, Rijkers, G & Kort, R 2018, ' A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands ', Bmc Gastroenterology, vol. 18, 103, pp. 1-12 . https://doi.org/10.1186/s12876-018-0831-x
BMC Gastroenterology, 103, 18
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-12 (2018)

Background Antibiotic-associated diarrhea (AAD) is a side-effect frequently associated with the use of broad spectrum antibiotics. Although a number of clinical studies show that co-administration of specific probiotics reduces the risk for AAD, ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07d102905c56811de733eb42ba99291
https://research.vu.nl/en/publications/1858d588-4ba6-44d1-9368-639f225e2532

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

Autor: Anne M. van der Does, Pieter S. Hiemstra, Gwendolynn Grootaers, Cyrille Krul, Ingeborg M. Kooter

Publikováno v: Toxicology in Vitro, 47, 137-146
Toxicology in Vitro

The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70808b9a80d0bdfd0305ea19692c69c2
http://resolver.tudelft.nl/uuid:8d77ec9e-05ac-4abd-b793-f38d5449e923

Toward a mechanism-based in vitro safety test for pertussis toxin

Autor: Rogier Bos, Stefan Vaessen, Saertje Verkoeijen, Martijn W.P. Bruysters, Rob J. Vandebriel, Arnoud M. Akkermans, Cyrille Krul

Publikováno v: Human Vaccines & Immunotherapeutics. 10:1391-1395

Pertussis vaccines are routinely administered to infants to protect them from whooping cough. Still, an adequate safety test for pertussis toxin (PT), one of the main antigens in these vaccines, is not available. The histamine sensitization test is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc3c8f22bea823855b325f3be57f5ea
https://doi.org/10.4161/hv.28001