Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Cyril Statzer"'
Autor:
Simon L. April-Monn, Philipp Kirchner, Katharina Detjen, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous malignancy. We established patient-de
Externí odkaz:
https://doaj.org/article/4501b816ee864b8c8c471a5b031bef76
Autor:
Alina C. Teuscher, Cyril Statzer, Anita Goyala, Seraina A. Domenig, Ingmar Schoen, Max Hess, Alexander M. Hofer, Andrea Fossati, Viola Vogel, Orcun Goksel, Ruedi Aebersold, Collin Y. Ewald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role o
Externí odkaz:
https://doaj.org/article/c0e058623cd74bde8b2a47d1ff75c848
Autor:
Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.
Externí odkaz:
https://doaj.org/article/0b2d369bb38048e0accd70b4ceb4ae16
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1212 (2023)
The extracellular matrix (ECM) is earning an increasingly relevant role in many disease states and aging. The analysis of these disease states is possible with the GWAS and PheWAS methodologies, and through our analysis, we aimed to explore the relat
Externí odkaz:
https://doaj.org/article/e80646181df74223a7a502bee055c53d
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103983- (2022)
Summary: Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of mor
Externí odkaz:
https://doaj.org/article/7ee0bf8665b84633a3aae41178ac2e23
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Although genetic approaches have identified key genes and pathways that promote longevity, systems-level approaches are less utilized. Here, we took advantage of the wealth of omics data characterizing the BXD family of mice. We associated transcript
Externí odkaz:
https://doaj.org/article/838c954dc4694c1db9632c80cc1aaaef
Autor:
Cyril Statzer, Collin Y. Ewald
Publikováno v:
Matrix Biology Plus, Vol 8, Iss , Pp 100039- (2020)
Extracellular matrices are essential for cellular and organismal function. Recent genome-wide and phenome-wide association studies started to reveal a broad spectrum of phenotypes associated with genetic variants. However, the phenome or spectrum of
Externí odkaz:
https://doaj.org/article/e2c4b81250e64e0389f93f4ef4693e82
Autor:
Alina C. Teuscher, Elisabeth Jongsma, Martin N. Davis, Cyril Statzer, Jan M. Gebauer, Alexandra Naba, Collin Y. Ewald
Publikováno v:
Matrix Biology Plus, Vol 1, Iss , Pp - (2019)
Proteins are the building blocks of life. While proteins and their localization within cells and sub-cellular compartments are well defined, the proteins predicted to be secreted to form the extracellular matrix - or matrisome - remain elusive in the
Externí odkaz:
https://doaj.org/article/e3bcd596b0e7403e82be7ea3f28c72d4
Autor:
Dominic F. Bennett, Anita Goyala, Cyril Statzer, Charles W. Beckett, Alexander Tyshkovskiy, Vadim N. Gladyshev, Collin Y. Ewald, João Pedro de Magalhães
Publikováno v:
Aging Cell, 22 (2)
Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature to caloric restriction and identified ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fb8ec041bd04c6c0300179a963d583
https://hdl.handle.net/20.500.11850/596274
https://hdl.handle.net/20.500.11850/596274
Autor:
Simon L. April-Monn, Katharina Detjen, Philipp Kirchner, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous epithelial malignancy. We established patient-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb14c55c77b4f97ea94822d0fdde77a
https://doi.org/10.1101/2022.12.10.519855
https://doi.org/10.1101/2022.12.10.519855