Výsledky vyhledávání - "Cyril P. Clarke"

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

Autor: Rafael D. Escandon, Khalil G. Saikali, Mohammad R. Habibzadeh, Jacqueline H. Lee, Cyril P. Clarke, Jonathan H. Goldman, Michael M. Chen, John R. Teerlink, Fady I. Malik, Lyndsey Elliott, Nelson B. Schiller, Andrew A. Wolff, Rachel Bee

Publikováno v: The Lancet. 378:667-675

Decreased systolic function is central to the pathogenesis of heart failure in millions of patients worldwide, but mechanism-related adverse effects restrict existing inotropic treatments. This study tested the hypothesis that omecamtiv mecarbil, a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd396dfc8e95962882de4268935a56c
https://doi.org/10.1016/s0140-6736(11)61219-1

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Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia

Autor: Märta Segerdahl, Karin Huizar, Cyril P. Clarke, Jarkko Kalliomäki, Peter Annas, Rolf Karlsten, Annika Zettergren

Publikováno v: Clinical and experimental pharmacologyphysiology. 40(3)

Summary The aim of the present study was to investigate the effects of AZD1940, a novel peripherally acting cannabinoid CB1/CB2 receptor agonist, on capsaicin-induced pain and hyperalgesia, as well as on biomarkers of cannabinoid central nervous syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8439d83a2353ecceaa4188af673f6ad0
https://pubmed.ncbi.nlm.nih.gov/23324098

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The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: A double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

Background: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are characteristic of systolic heart failure and might

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa99c2c5e061ae2c3857a9ccf20ee531
https://acuresearchbank.acu.edu.au/item/88q4w/the-effects-of-the-cardiac-myosin-activator-omecamtiv-mecarbil-on-cardiac-function-in-systolic-heart-failure-a-double-blind-placebo-controlled-crossover-dose-ranging-phase-2-trial

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Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans

Autor: Gavin Brown, Stefan Bradley, Cyril P Clarke, Andrew W Philipp, Peter S. Talbot, Adam McMahon, Kola O Babalola, Julian C. Matthews

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 35(3)

Sibutramine is a centrally acting monoamine reuptake inhibitor prescribed as an appetite suppressant in the management of obesity. Its effects are mostly attributable to serotonin and norepinephrine transporter (SERT and NET, respectively) inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bfe385936d55241b3dda7bb08b1a90
https://pubmed.ncbi.nlm.nih.gov/19890256

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The Selective Cardiac Myosin Activator, CK-1827452, Increases Systolic Function in a Concentration-Dependent Manner in Patients with Stable Heart Failure (10/8/08)

Autor: Cyril P. Clarke, V.A. Tsyrlin, Chim C. Lang, Jamil Mayet, Andrew A. Wolff, Mark J. Monaghan, G. Brand, Darrel P. Francis, Barry H. Greenberg, Ludwig Neyses, Jonathan H. Goldman, Jacqueline H. Lee, John J.V. McMurray, John R. Teerlink, Fady I. Malik, Roxy Senior, John G.F. Cleland, E.M. Nifontov, Khalil G. Saikali

Publikováno v: Journal of Cardiac Failure. 14:797-798

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c4f5ea6872c9725c2f6db414e596ffd
https://doi.org/10.1016/j.cardfail.2008.10.012

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First clinical trial of the selective cardiac myosin activator, CK-1827452, in Heart Failure: effect of dose and plasma concentration on systolic function

Autor: Cyril P. Clarke, Jonathan H. Goldman, John G.F. Cleland, Chim C. Lang, John J.V. McMurray, Khalil G. Saikali, John R. Teerlink, Fady I. Malik, Jacqueline H. Lee, Ludwig Neyses

Publikováno v: European Journal of Heart Failure Supplements. 7:189-190

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6af94d985c247c032c6a076b964c2389
https://doi.org/10.1016/s1567-4215(08)60526-3

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Systolic Ejection Time Is a Sensitive Indicator of Left Ventricular Systolic Function during Treatment with the Selective Cardiac Myosin Activator, CK-1827452

Autor: Cyril P. Clarke, John R. Teerlink, Fady I. Malik, Andrew A. Wolff, Khalil G. Saikali

Publikováno v: Journal of Cardiac Failure. 13:S145-S146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05ca6c2751fd1c2ae2cc4f459ac34833
https://doi.org/10.1016/j.cardfail.2007.06.614

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Oral Bioavailability of the Selective Cardiac Myosin Activator CK-1827452: Chronic Oral Inotropic Therapy for Heart Failure?

Autor: Markus Jerling, Cyril P. Clarke, Rafael D. Escandon, Ester Venables, Fady I. Malik, Andrew A. Wolff, Jacqueline H. Lee, Terence Chew

Publikováno v: Journal of Cardiac Failure. 13:S148

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2217ef32dad483f7b6e0a6e2fd2ff025
https://doi.org/10.1016/j.cardfail.2007.06.622

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The Selective Cardiac Myosin Activator, CK-1827452, Increases Left Ventricular Systolic Function by Increasing Ejection Time: Results of a First-in-Human Study of a Unique and Novel Mechanism

Autor: Andrew A. Wolff, Jacqueline H. Lee, Cyril P. Clarke, Khalil G. Saikali, Rafael D. Escandon, John R. Teerlink, Fady I. Malik

Publikováno v: Journal of Cardiac Failure. 12:763

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a9b84eb27c0c19c1ac90ea072ea8a8f
https://doi.org/10.1016/j.cardfail.2006.10.007

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