Výsledky vyhledávání - "Cyril Nicolas"

Akademický článek

Autor: Baptiste Taffoureau, Isabelle Gillaizeau, Pascal Retailleau, Cyril Nicolas

Publikováno v: Molbank, Vol 2022, Iss 2, p M1382 (2022)

The synthesis and crystallization of 2,3,5-tri-O-benzyl-d-xylofuranose permitted us to isolate the alpha anomer with a small contamination of the beta form (ca 10%), whose first crystallographic structure obtained in the P212121 space group was deter

Externí odkaz: https://doaj.org/article/72f36923f4124b2e84466ae221912162

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Akademický článek

Synthesis and Structure–Activity Relationship Studies of Pyrido [1,2-e]Purine-2,4(1H,3H)-Dione Derivatives Targeting Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis

Autor: Nicolas G. Biteau, Vincent Roy, Cyril Nicolas, Hubert F. Becker, Jean-Christophe Lambry, Hannu Myllykallio, Luigi A. Agrofoglio

Publikováno v: Molecules, Vol 27, Iss 19, p 6216 (2022)

In 2002, a new class of thymidylate synthase (TS) involved in the de novo synthesis of dTMP named Flavin-Dependent Thymidylate Synthase (FDTS) encoded by the thyX gene was discovered; FDTS is present only in 30% of prokaryote pathogens and not in hum

Externí odkaz: https://doaj.org/article/fa166c10908c426bb800a1ee50e5ea63

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Akademický článek

Glycoside Mimics from Glycosylamines: Recent Progress

Autor: Cyril Nicolas, Olivier R. Martin

Publikováno v: Molecules, Vol 23, Iss 7, p 1612 (2018)

Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds. Iminosugars are among the most important glycomimetics reported to date due to their powerful act

Externí odkaz: https://doaj.org/article/b39ac51155864ea9a48089e777755b8a

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Report

Comparison of experimental and simulation distortions of quenched C-ring test parts

Autor: Cyril, Nicolas, Cyrille, Baudouin, Stéphane, Leleu, Mihaela, Teodorescu, Régis, Bigot

Publikováno v: 12th International ESAFORM Conference on Material Forming. ESAFORM 2009., Enschede : Pays-Bas (2009)

We present a mathematical method for identifying, separating and quantifying the 3D significant distortions. Measurement of a gas quenched C-ring type sample is performed by a Coordinate Measuring Machine (CMM). Quenching simulation is done with the

Externí odkaz: http://arxiv.org/abs/1002.0572

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Tunable Approach to C-Linked Analogs of Glycosamines

Autor: Tuniyazi Abuduaini, Sizhe Li, Vincent Roy, Luigi A. Agrofoglio, Olivier R. Martin, Cyril Nicolas

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, In press, ⟨10.1021/acs.joc.2c01650⟩

International audience; The synthesis of (1R)-2-amino-2-deoxy-β-L-gulopyranosyl benzene, and the α and β form of 2-amino-2-deoxy-Lidopyranosyl benzene derivatives was accomplished through stereospecific addition of tributylstannyllithium to readil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ad321ecb0e5b1f4d31b26df8bd543b
https://pubmed.ncbi.nlm.nih.gov/36082689

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Olefin Hydrofunctionalization; Hydrofunctionalization of Olefins With P, S, and Se Heteroatoms

Autor: Isabelle Gillaizeau, Cyril Nicolas, Liliane Mimoun, Killian Tiger

Publikováno v: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering ISBN: 9780124095472
Comprehensive Chirality
Cossy, Janine. Comprehensive Chirality, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, 2022, ⟨10.1016/B978-0-32-390644-9.00043-3⟩

International audience; Asymmetric hydrochalcogenylation of olefins, including hydrophosphination, hydrosulfenylation and hydroselenation, has emerged as a powerful approach for constructing chiral compounds in an enantioselective manner by generatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49de66dc833bb9877591cf0f466315c
https://doi.org/10.1016/b978-0-32-390644-9.00043-3

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Asymmetric synthesis of the two enantiomers of $\beta$-phosphorus-containing-$\alpha$-Amino Acids via hydrophosphinylation and hydrophosphonylation of chiral Ni(II)-complexes

Autor: Isabelle Gillaizeau, Angéline Noireau, Vadim A. Soloshonok, Hiroki Moriwaki, Hiroyuki Konno, Yoshinori Tokairin, Cyril Nicolas, Caroline West

Publikováno v: Organic Chemistry Frontiers
Organic Chemistry Frontiers, Royal Society of Chemistry, 2021, 8 (1-4), ⟨10.1039/D1QO00159K⟩
Organic Chemistry Frontiers, 2021, 8 (1-4), ⟨10.1039/D1QO00159K⟩

A new approach for the synthesis of the two enantiomers of β-phosphorus-containing α-amino acids was developed via Michael addition of secondary phosphine oxides and dialkyl phosphites to chiral Ni(ii)-complexes of a dehydroalanine-Schiff base.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab70a439b127184b4048ec4129c1db2f
https://hal.archives-ouvertes.fr/hal-03359971/document

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Iron Catalyzed B-C(sp2 )-H Alkylation of Enamides

Autor: Sylvain Bertho, Raoudha Abderrahim, Radhouan Maazaoui, Cyril Nicolas, Isabelle Gillaizeau, Ismaël Dondasse, Damla Torun

Publikováno v: New Journal of Chemistry
New Journal of Chemistry, 2021, 45 (37), pp.17475-17482. ⟨10.1039/D1NJ03673D⟩
New Journal of Chemistry, Royal Society of Chemistry, 2021, 45 (37), pp.17475-17482. ⟨10.1039/D1NJ03673D⟩

International audience; An attractive atom-economic way was developed for the BC(sp 2)-H (fluoro)alkylation of a range of acyclic and cyclic non-aromatic enamides using either FeCl2 as a catalyst or a stoichiometric amount of low-cost iron powder. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33187bfb757a7d773c59a1ec10174589
https://hal.science/hal-03360102/document

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Stereospecific synthesis of glycoside mimics through Migita-Kosugi-Stille cross-coupling reactions of chemically and configurationally stable 1-C-tributylstannyl iminosugars

Autor: Thomas Poisson, Sizhe Li, Xavier Pannecoucke, Justyna Jaszczyk, Olivier R. Martin, Cyril Nicolas

Publikováno v: Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, 2020, 363, pp.470-483. ⟨10.1002/adsc.202000886⟩
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2020, 363, pp.470-483. ⟨10.1002/adsc.202000886⟩

International audience; An innovative and effective strategy for the synthesis of imino-C-glycosides is described. The methodology is based on the unprecedent reaction of 1-C-stannylated iminosugars with various electrophiles under the conditions of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9525e0e0a4088d6a2adced969f9cc814
https://hal.science/hal-02989536

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beta-C(sp2)-H Alkylation of enamides using xanthate chemistry

Autor: Isabelle Gillaizeau, Pascal Retailleau, Sylvain Bertho, Ismaël Dondasse, Cyril Nicolas

Publikováno v: New Journal of Chemistry
β-C(sp2)-H Alkylation of enamides using xanthate chemistry
New Journal of Chemistry, Royal Society of Chemistry, 2020, ⟨10.1039/D0NJ01209B⟩
New Journal of Chemistry, 2020, ⟨10.1039/D0NJ01209B⟩

Access to the γ-amino-β,γ-unsaturated acyl scaffold was established by applying xanthate chemistry to enamides. This original β-C(sp2)–H alkylation is regioselective and exhibits broad substrate scope and good functional group tolerance. The la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e8338cc8abae5532994fb15fadbcec
https://hal.archives-ouvertes.fr/hal-02990031

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