Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Cyril Le Nouën"'
Autor:
Jaclyn A. Kaiser, Christine E. Nelson, Xueqiao Liu, Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Celia Santos, Laura R. H. Ahlers, Richard Herbert, Ian N. Moore, Temeri Wilder-Kofie, Rashida Moore, April Walker, Lijuan Yang, Shirin Munir, I-Ting Teng, Peter D. Kwong, Kennichi Dowdell, Hanh Nguyen, JungHyun Kim, Jeffrey I. Cohen, Reed F. Johnson, Nicole L. Garza, Laura E. Via, Daniel L. Barber, Ursula J. Buchholz, Cyril Le Nouën
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Immunization via the respiratory route is predicted to increase the effectiveness of a SARS-CoV-2 vaccine. Here, we evaluate the immunogenicity and protective efficacy of one or two doses of a live-attenuated murine pneumonia virus vector ex
Externí odkaz:
https://doaj.org/article/09d66d03187f4f05a10b4b61eaa3febc
Autor:
Christine E Nelson, Taylor W Foreman, Eduardo R Fukutani, Keith D Kauffman, Shunsuke Sakai, Joel D Fleegle, Felipe Gomez, NIAID/DIR Tuberculosis Imaging Program, Sydnee T Gould, Cyril Le Nouën, Xueqiao Liu, Tracey L Burdette, Nicole L Garza, Bernard A P Lafont, Kelsie Brooks, Cecilia S Lindestam Arlehamn, Daniela Weiskopf, Alessandro Sette, Heather D Hickman, Ursula J Buchholz, Reed F Johnson, Jason M Brenchley, James P Oberman, Artur T L Quieroz, Bruno B Andrade, Laura E Via, Daniel L Barber
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012339 (2024)
The regulation of inflammatory responses and pulmonary disease during SARS-CoV-2 infection is incompletely understood. Here we examine the roles of the prototypic pro- and anti-inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of
Externí odkaz:
https://doaj.org/article/4f2fca22c4d14a298492237eba187e8e
Autor:
Megan Levy, Jessica W Chen, Jaclyn A Kaiser, Hong-Su Park, Xueqiao Liu, Lijuan Yang, Celia Santos, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012198 (2024)
Respiratory syncytial virus (RSV) is the most important viral agent of severe pediatric respiratory illness worldwide, but there is no approved pediatric vaccine. Here, we describe the development of the live-attenuated RSV vaccine candidate Min AL a
Externí odkaz:
https://doaj.org/article/0125f493245a43bd86c11a2816ec7e68
Autor:
Jaclyn A. Kaiser, Xueqiao Liu, Cindy Luongo, Yumiko Matsuoka, Celia Santos, Lijuan Yang, Richard Herbert, Ashley Castens, David W. Dorward, Reed F. Johnson, Hong-Su Park, Sharmin Afroz, Shirin Munir, Cyril Le Nouën, Ursula J. Buchholz
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108490- (2023)
Summary: Next-generation SARS-CoV-2 vaccines are needed that induce systemic and mucosal immunity. Murine pneumonia virus (MPV), a murine homolog of respiratory syncytial virus, is attenuated by host-range restriction in nonhuman primates and has a t
Externí odkaz:
https://doaj.org/article/cbf4d88789d345baa457b5b0e0bb1922
Autor:
Xueqiao Liu, Hong-Su Park, Yumiko Matsuoka, Celia Santos, Lijuan Yang, Cindy Luongo, Ian N Moore, Reed F Johnson, Nicole L Garza, Peng Zhang, Paolo Lusso, Sonja M Best, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011057 (2023)
The pediatric live-attenuated bovine/human parainfluenza virus type 3 (B/HPIV3)-vectored vaccine expressing the prefusion-stabilized SARS-CoV-2 spike (S) protein (B/HPIV3/S-2P) was previously evaluated in vitro and in hamsters. To improve its immunog
Externí odkaz:
https://doaj.org/article/eb32882f2f894b40aeab331f51b202e1
Autor:
Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Lijuan Yang, Celia Santos, Xueqiao Liu, Laura R. H. Ahlers, Ian N. Moore, Sharmin Afroz, Reed F. Johnson, Bernard A. P. Lafont, David W. Dorward, Elizabeth R. Fischer, Craig Martens, Siba K. Samal, Shirin Munir, Ursula J. Buchholz, Cyril Le Nouën
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract Current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are administered parenterally and appear to be more protective in the lower versus the upper respiratory tract. Vaccines are needed that directly stimulate
Externí odkaz:
https://doaj.org/article/b63359b706ef44b6802329d81a42cb7c
Autor:
Jessica W Chen, Lijuan Yang, Celia Santos, Sergio A Hassan, Peter L Collins, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010191 (2021)
Recoding viral genomes by introducing numerous synonymous nucleotide substitutions that create suboptimal codon pairs provides new live-attenuated vaccine candidates. Because recoding typically involves a large number of nucleotide substitutions, the
Externí odkaz:
https://doaj.org/article/8c178583c7004955bec99733a25f6037
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Using computer algorithms and commercial DNA synthesis, one or more ORFs of a microbial pathogen such as a virus can be recoded and deoptimized by several strategies that may involve the introduction of up to thousands of nucleotide (nt) changes with
Externí odkaz:
https://doaj.org/article/6bef0b5eb6c54411b48faa02fa2293ca
Autor:
Masfique Mehedi, Thomas McCarty, Scott E Martin, Cyril Le Nouën, Eugen Buehler, Yu-Chi Chen, Margery Smelkinson, Sundar Ganesan, Elizabeth R Fischer, Linda G Brock, Bo Liang, Shirin Munir, Peter L Collins, Ursula J Buchholz
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006062 (2016)
Human respiratory syncytial virus (RSV) is an enveloped RNA virus that is the most important viral cause of acute pediatric lower respiratory tract illness worldwide, and lacks a vaccine or effective antiviral drug. The involvement of host factors in
Externí odkaz:
https://doaj.org/article/f1b2abcfed104beeafe98c4990482e0c
Autor:
Cyril Le Nouën, Didier Toquin, Hermann Müller, Rüdiger Raue, Katherine M Kean, Patrick Langlois, Martine Cherbonnel, Nicolas Eterradossi
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28064 (2012)
BACKGROUND: Infectious bursal disease virus (IBDV) is a pathogen of worldwide significance to the poultry industry. IBDV has a bi-segmented double-stranded RNA genome. Segments A and B encode the capsid, ribonucleoprotein and non-structural proteins,
Externí odkaz:
https://doaj.org/article/fe179aab92034c27a3604fe9a297b5f2