Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Cyril C. Curtain"'
Autor:
Kathleen Wood, Timothy M. Ryan, Duncan J. McGillivray, Cyril C. Curtain, Nigel Kirby, Michael D. W. Griffin, Robert Knott, Colin L. Masters
Publikováno v:
Biophysical Journal. 110(1):85-94
The formation of amyloid deposits is a common feature of a broad range of diseases, including atherosclerosis, Alzheimer's disease, and Parkinson's disease. The basis and role of amyloid deposition in the pathogenesis of these diseases is still being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bc22ce687bfeab11f819d7f22341dc
Small angle X-ray scattering analysis of Cu2+-induced oligomers of the Alzheimer's amyloid β peptide
Autor:
Chi L.L. Pham, Cyril C. Curtain, Kevin J. Barnham, Colin L. Masters, Roberto Cappai, Haydyn D. T. Mertens, Blaine R. Roberts, Nigel Kirby, Timothy M. Ryan
Publikováno v:
Metallomics. 7:536-543
Research into causes of Alzheimer's disease and its treatment has produced a tantalising array of hypotheses about the role of transition metal dyshomeostasis, many of them on the interaction of these metals with the neurotoxic amyloid-β peptide (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd90bb5ed37ac06a8704340a576da56a
https://doi.org/10.1039/c4mt00323c
https://doi.org/10.1039/c4mt00323c
Autor:
Tong-Lay Lau, John D. Wade, Timothy Johanssen, Cyril C. Curtain, Varsha Lal, Kevin J. Barnham, Jeffrey P. Smith, Roberto Cappai, Giuseppe D. Ciccotosto, Colin L. Masters, Deborah J. Tew, Danielle G. Smith, Keyla Perez, Frances Separovic, Simon C. Drew
Publikováno v:
Neurobiology of Aging. 32:235-248
Previous studies suggest membrane binding is a key determinant of amyloid β (Aβ) neurotoxicity. However, it is unclear whether this interaction is receptor driven. To address this issue, a D-handed enantiomer of Aβ42 (D-Aβ42) was synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507e07d4491df8bf24a4c7869bf1575d
https://doi.org/10.1016/j.neurobiolaging.2009.02.018
https://doi.org/10.1016/j.neurobiolaging.2009.02.018
Autor:
Roberto Cappai, Kevin J. Barnham, Cyril C. Curtain, Keyla Perez, Colin L. Masters, Deborah J. Tew, Giuseppe D. Ciccotosto, Danielle G. Smith, John F. Boas
Publikováno v:
Journal of Alzheimer's Disease. 19:1387-1400
Amyloid-beta peptide (Abeta) toxicity is thought to be responsible for the neurodegeneration associated with Alzheimer's disease. While the mechanism(s) that modulate this toxicity are still widely debated, it has previously been demonstrated that mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587dfefdb88ae116b760f74fb77211a5
https://doi.org/10.3233/jad-2010-1334
https://doi.org/10.3233/jad-2010-1334
Publikováno v:
Animal Blood Groups and Biochemical Genetics. 4:101-109
Summary Wild rabbit populations from several parts of south-eastern Australia and from Tasmania and Macquarie Island were tested for the As1, As2, As3 (a locus) and the As4, As5, As6, As9 (b locus) allotypic IgG markers. All markers except As6 were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d88aa541fcb5465173fa3fa79f3a4d2
https://doi.org/10.1111/j.1365-2052.1973.tb01279.x
https://doi.org/10.1111/j.1365-2052.1973.tb01279.x
Autor:
Anthony R. White, Peter J. Crouch, Paul S. Donnelly, Colin L. Masters, Cyril C. Curtain, Katherine A. Price
Publikováno v:
Journal of Cellular and Molecular Medicine
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by numerous pathological features including the accumulation of neurotoxic amyloid-beta (Abeta) peptide. There is currently no effective therapy for AD, but the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea21944c83e82eb691a98da22280b862
https://doi.org/10.1111/j.1582-4934.2008.00642.x
https://doi.org/10.1111/j.1582-4934.2008.00642.x
Autor:
Hugh H. Harris, Julian J. Adams, John F. Boas, Roberto Cappai, William J. McKinstry, Colin L. Masters, Michael W. Parker, Kevin J. Barnham, Cyril C. Curtain, Geoffrey K-W Kong, Denise Galatis
Publikováno v:
Journal of Molecular Biology. 367:148-161
Alzheimer's disease (AD) is the major cause of dementia. Amyloid beta peptide (Abeta), generated by proteolytic cleavage of the amyloid precursor protein (APP), is central to AD pathogenesis. APP can function as a metalloprotein and modulate copper (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5fdaed2e225cce88266a762e931f19
https://doi.org/10.1016/j.jmb.2006.12.041
https://doi.org/10.1016/j.jmb.2006.12.041
Autor:
Dominic J. Hare, Timothy M. Ryan, Colin L. Masters, Blaine R. Roberts, Kevin J. Barnham, Cyril C. Curtain, Mark G. Hinds, Gawain McColl
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28910e8239332d4137d7bf72ffdfaf1f
https://doi.org/10.1016/j.jalz.2015.07.429
https://doi.org/10.1016/j.jalz.2015.07.429
Autor:
Anne M. Roberts, Qiao-Xin Li, Philip Doble, Colin L. Masters, Kevin J. Barnham, Gawain McColl, Monica Lind, Blaine R. Roberts, Paul A. Adlard, Haydyn D. T. Mertens, Nigel Kirby, Mark G. Hinds, Cyril C. Curtain, Dominic J. Hare, Timothy M. Ryan, Chi L.L. Pham
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(7)
The extracellular accumulation of amyloid β (Aβ) peptides is characteristic of Alzheimer's disease (AD). However, formation of diffusible, oligomeric forms of Aβ, both on and off pathways to amyloid fibrils, is thought to include neurotoxic specie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f51d2707874ab34bf8d88d548db0c8
https://pubmed.ncbi.nlm.nih.gov/25698727
https://pubmed.ncbi.nlm.nih.gov/25698727
Autor:
Colin L. Masters, Roberto Cappai, Robert A. Cherny, James A. Duce, Thomas Dyrks, Kevin J. Barnham, Qiao-Xin Li, Ian A. Trounce, Peter J. Crouch, Rachel E. Blake, Giuseppe D. Ciccotosto, Cyril C. Curtain
Publikováno v:
The Journal of Neuroscience. 25:672-679
In studies of Alzheimer's disease pathogenesis there is an increasing focus on mechanisms of intracellular amyloid-β (Aβ) generation and toxicity. Here we investigated the inhibitory potential of the 42 amino acid Aβ peptide (Aβ1-42) on activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fb57ee43e8cc81d37c4ca7ae5598bc
https://doi.org/10.1523/jneurosci.4276-04.2005
https://doi.org/10.1523/jneurosci.4276-04.2005