Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cyril Bauvais"'
Autor:
Aixiao Li, Ahmed Bouhss, Marie-Jeanne Clément, Cyril Bauvais, J. Paul Taylor, Guillaume Bollot, David Pastré
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In recent years, RNA has gained traction both as a therapeutic molecule and as a therapeutic target in several human pathologies. In this review, we consider the approach of targeting RNA using small molecules for both research and therapeutic purpos
Externí odkaz:
https://doaj.org/article/22c47e5584934302a02e842601707265
Autor:
Krystel El Hage, Nicolas Babault, Olek Maciejak, Bénédicte Desforges, Pierrick Craveur, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie-Jeanne Clement, Vandana Joshi, Ahmed Bouhss, Liya Wang, Cyril Bauvais, David Pastré
Publikováno v:
eLife, Vol 12 (2023)
RNA-protein interactions (RPIs) are promising targets for developing new molecules of therapeutic interest. Nevertheless, challenges arise from the lack of methods and feedback between computational and experimental techniques during the drug discove
Externí odkaz:
https://doaj.org/article/fba7b44d6c2f4d60b2a3433ce6ea930d
Autor:
Claude Hercend, Cyril Bauvais, Guillaume Bollot, Nicolas Delacotte, Philippe Chappuis, France Woimant, Jean-Marie Launay, Philippe Manivet
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26245 (2011)
The diagnostic of orphan genetic disease is often a puzzling task as less attention is paid to the elucidation of the pathophysiology of these rare disorders at the molecular level. We present here a multidisciplinary approach using molecular modelin
Externí odkaz:
https://doaj.org/article/5b1f2f3efb1741888e3f06da6b1635ad
Autor:
Krystel El Hage, Nicolas Babault, Olek Maciejak, Bénédicte Desforges, Pierrick Craveur, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie-Jeanne Clement, Vandana Joshi, Ahmed Bouhss, Liya Wang, Cyril Bauvais, David Pastré
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad604070ba5cb2bd19a23cc14dcd4edd
https://doi.org/10.7554/elife.80387.sa2
https://doi.org/10.7554/elife.80387.sa2
Autor:
Camille Hauguel, Sarah Ducellier, Olivier Provot, Nada Ibrahim, Diana Lamaa, Coline Balcerowiak, Boris Letribot, Megane Nascimento, Vincent Blanchard, Laurie Askenatzis, Helene Levaique, Jérôme Bignon, Francesco Baschieri, Cyril Bauvais, Guillaume Bollot, Dolor Renko, Alain Deroussent, Bastien Prost, Marie-Catherine Laisne, Sophie Michallet, Laurence Lafanechère, Sébastien Papot, Guillaume Montagnac, Christine Tran, Mouad Alami, Sebastien Apcher, Abdallah Hamze
Publikováno v:
European Journal of Medicinal Chemistry. 240:114573
A series of quinoline and quinazoline analogs were designed and synthesized as new tubulin polymerization (TP) and histone deacetylases (HDAC) inhibitors. Compounds 12a and 12d showed the best cytotoxicity activities against a panel of human cancer c
Autor:
Melkon, Iradyan, Nina, Iradyan, Philippe, Hulin, Artur, Hambardzumyan, Aram, Gyulkhandanyan, Rodolphe, Alves de Sousa, Assia, Hessani, Christos, Roussakis, Guillaume, Bollot, Cyril, Bauvais, Vehary, Sakanyan
Publikováno v:
Cancers
Cancers, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Cancers, MDPI, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Cancers, Vol 11, Iss 8, p 1094 (2019)
Cancers, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Cancers, MDPI, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Cancers, Vol 11, Iss 8, p 1094 (2019)
Targeting epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKI) has been widely exploited to disrupt aberrant phosphorylation flux in cancer. However, a bottleneck of potent TKIs is the acquisition of drug resistance mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a3c2a60f4fb1f35cfa8feda4f4c16599
https://hal-univ-evry.archives-ouvertes.fr/hal-02321259/document
https://hal-univ-evry.archives-ouvertes.fr/hal-02321259/document
Autor:
François Saller, Cyril Bauvais, Hsin-Ping Lin, Hazar Al-Mouhammad, Guillaume Bollot, Martin Souce, Diana Lamaa, Olivier Pamlard, Athena Kasselouri, Abdallah Hamze, Joëlle Dubois, Lena Zig, Mehdi Ouaissi, Delphine Borgel, Jean Feuillard, Hélène Levaique, Chantal Jayat-Vignoles, Mouad Alami, Jérôme Bignon, Karim Benihoud
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (15), pp.6574-6591. ⟨10.1021/acs.jmedchem.8b00050⟩
Journal of Medicinal Chemistry, 2018, 61 (15), pp.6574-6591. ⟨10.1021/acs.jmedchem.8b00050⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (15), pp.6574-6591. ⟨10.1021/acs.jmedchem.8b00050⟩
Journal of Medicinal Chemistry, 2018, 61 (15), pp.6574-6591. ⟨10.1021/acs.jmedchem.8b00050⟩
Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge in antitumor drug discovery. The present study reports a dual inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1155c1448eba740efe4d939aa2d5d820
https://hal.archives-ouvertes.fr/hal-02309817
https://hal.archives-ouvertes.fr/hal-02309817
Autor:
Martha Cecilia Rosales-Hernández, Vandana Joshi, Michel Cailleret, Martha Edith Macías Pérez, Cyril Bauvais, Flavio Toma, Andrea Burgo, Imane Hamdi, Guillaume Bollot, Patrick A. Curmi, Marie-Jeanne Clément, Daoudi Chabane-Sari, Meryem Sari-Hassoun
Publikováno v:
Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2016, 102, pp.45-63. ⟨10.1016/j.bcp.2015.12.013⟩
Biochemical Pharmacology, 2016, 102, pp.45-63. ⟨10.1016/j.bcp.2015.12.013⟩
Biochemical Pharmacology, Elsevier, 2016, 102, pp.45-63. ⟨10.1016/j.bcp.2015.12.013⟩
Biochemical Pharmacology, 2016, 102, pp.45-63. ⟨10.1016/j.bcp.2015.12.013⟩
International audience; Cucurbitacins are cytotoxic triterpenoid sterols isolated from plants. One of their earliest cellular effect is the aggregation of actin associated with blockage of cell migration and division that eventually lead to apoptosis
Autor:
Andrea Bordessa, Massaba Keita, Jean-Louis Soulier, Cyril Bauvais, Sandrine Ongeri, Lucia Formicola, Guillaume Bernadat, Michèle Reboud-Ravaux, Benoit Crousse, Jordi Rodrigo, Laure Dufau, Thierry Milcent, Nathalie Lagarde, Xavier Maréchal
Publikováno v:
European journal of medicinal chemistry. 70
We describe the synthesis of a library of new pseudopeptides and their inhibitory activity of the rabbit 20S proteasome chymotrypsin-like (ChT-L) activity. We replaced a natural α-amino acid by an α- or a β-hydrazino acid and obtained inhibitors o