Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Cyril B. Frank"'
Autor:
Kate O’Brien, Pankaj Tailor, Catherine Leonard, Lisa M. DiFrancesco, David A. Hart, John R. Matyas, Cyril B. Frank, Roman J. Krawetz
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 4, p 774 (2017)
Osteoarthritis (OA) is a degenerative disorder characterized by chondrocyte apoptosis and degeneration of articular cartilage resulting in loss of mobility and pain. Inflammation plays a key role in the development and progression of OA both on the s
Externí odkaz:
https://doaj.org/article/6837fe9225e14539b8542faaa3acbe1b
Publikováno v:
Inflammation Research. 70:99-107
This study aimed at evaluating the effect of methylprednisolone (MPA) on messenger ribonucleic acid (mRNA) expression levels in immature ovine knee joint tissue explants following interleukin (IL)1β induction and to assess responsiveness of the expl
Autor:
Michael Scott, Mehdi Shekarforoush, Cyril B. Frank, Nigel G. Shrive, David A. Hart, Paris Vakiel, Christopher R. Dennison
Publikováno v:
Annals of Biomedical Engineering. 48:2836-2845
It has been hypothesized a change in stress on the cartilage of a joint is a significant factor in the initiation and progression of post-traumatic osteoarthritis. Without a reliable method for measuring stress, this hypothesis has largely gone untes
Autor:
C. Ryan Martin, Kristen I Barton, Cyril B. Frank, Nigel G. Shrive, Johnathan L. Sevick, Jillian E. Beveridge, David A. Hart, Mehdi Shekarforoush, Michael Scott, Bryan J. Heard, Gregory Muench
Publikováno v:
Annals of Biomedical Engineering. 47:790-801
Little effort has been directed towards the consequence of an injury on joint angular velocity. We hypothesized that the magnitude of knee joint angular velocity would be decreased after injury. Four injury groups were investigated in an ovine model:
Autor:
David A. Hart, Andres Kroker, C. Ryan Martin, Johnathan L. Sevick, May Chung, Cyril B. Frank, Yamini Achari, Kristen I Barton, Bryan J. Heard, Duncan A Raymond, Nigel G. Shrive, Steven K. Boyd
Publikováno v:
The American journal of sports medicine. 49(3)
Background: Severe injury to the knee joint often results in accelerated posttraumatic osteoarthritis (PTOA). In an ovine knee injury model, altered kinematics and degradation of the cartilage have been observed at 20 and 40 weeks after partial anter
Publikováno v:
Journal of Biomechanics. 75:67-76
The relations between kinematic abnormalities and post traumatic osteoarthritis have not yet been clearly elucidated. This study was conducted to determine the finite helical axes parameters and the tibiofemoral translation vector in the knee joints
Autor:
C. Ryan Martin, Bryan J. Heard, Kristen I Barton, Johnathan L. Sevick, David A. Hart, Cyril B. Frank, S.M. Mehdi Shekarforoush, Yamini Achari, May Chung, Nigel G. Shrive
Publikováno v:
The American Journal of Sports Medicine. 46:1596-1605
Background:Partial anterior cruciate ligament (p-ACL) ruptures are a common injury of athletes. However, few preclinical models have investigated the natural history and treatment of p-ACL injuries.Purpose:To (1) demonstrate whether a controlled p-AC
Autor:
John L Sevick, Bryan J. Heard, David A. Hart, Nigel G. Shrive, Cyril B. Frank, Ryan Martin, Kristen I Barton, Mohammad Atarod, Mehdi Shekarforoush
Publikováno v:
Journal of Medical and Biological Engineering. 38:273-283
Velocity analysis in a joint is a major area of interest in research involving the dynamics of joints and in diagnosing and monitoring the progression of some diseases such as osteoarthritis. In this study, we provide a general analytical method to d
Autor:
Bryan J. Heard, Mohammad Atarod, Jillian E. Beveridge, Cyril B. Frank, C. Rolian, E. J. O. O'Brien, David A. Hart, Nigel G. Shrive
Publikováno v:
BMC Musculoskeletal Disorders, Vol 18, Iss 1, Pp 1-10 (2017)
BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders
Background Many patients who undergo anterior cruciate ligament (ACL) reconstructive surgery develop post-traumatic osteoarthritis (PTOA). ACL reconstructive surgery may not fully restore pre-injury joint biomechanics, thereby resulting in further jo
Autor:
Bryan J. Heard, Mehdi Shekarforoush, Yamini Achari, C. Ryan Martin, David A. Hart, Paria Vakil, Cyril B. Frank, Kristen I Barton, John L Sevick, Nigel G. Shrive, Mohammad Atarod
Publikováno v:
Journal of Orthopaedic Research. 35:454-465
Post-traumatic osteoarthritis (PTOA) development is often observed following traumatic knee injuries involving key stabilising structures such as the cruciate ligaments or the menisci. Both biomechanical and biological alterations that follow knee in