Výsledky vyhledávání - "Cyril A. Clarke"

Anatomical and physiological basis for the allometric scaling of cisplatin clearance in dogs

Autor: Lara K. Maxwell, Satyanarayana Achanta, David W. A. Bourne, A. Sewell, K. Broaddus, J. W. Ritchey, Cyril R. Clarke

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 39:224-236

Cisplatin is a platinum-containing cytotoxic drug indicated for the treatment of solid tumors in veterinary and human patients. Several of the algorithms used to standardize the doses of cytotoxic drugs utilize allometry, or the nonproportional relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7482b62d4d0f786063749f58c05a39
https://doi.org/10.1111/jvp.12266

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Medical genetics in China

Autor: Walter F. Bodmer, Cyril A. Clarke

Publikováno v: Scopus-Elsevier

In many areas the Chinese are considered behind the western world in their biomedical research, but they are keen to catch up, have all the contacts needed for this, and work extremely hard. Human genetics seems to have been particularly affected dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6f3eaff6a1efe5454d4e1b4ead4437
https://ora.ox.ac.uk/objects/uuid:cec088a8-fa36-403d-a42b-86b99e12313e

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Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

Autor: Rafael D. Escandon, Khalil G. Saikali, Mohammad R. Habibzadeh, Jacqueline H. Lee, Cyril P. Clarke, Jonathan H. Goldman, Michael M. Chen, John R. Teerlink, Fady I. Malik, Lyndsey Elliott, Nelson B. Schiller, Andrew A. Wolff, Rachel Bee

Publikováno v: The Lancet. 378:667-675

Decreased systolic function is central to the pathogenesis of heart failure in millions of patients worldwide, but mechanism-related adverse effects restrict existing inotropic treatments. This study tested the hypothesis that omecamtiv mecarbil, a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd396dfc8e95962882de4268935a56c
https://doi.org/10.1016/s0140-6736(11)61219-1

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List of Contributors

Autor: DOUGLAS R. ANDERSON, SAMUEL B. ARONSON, M.A. BEDFORD, ISAAC BEN SIRA, ALAN C. BIRD, R.K. BLACH, JOHAN BOURS, DERRICK A. BREWERTON, NICHOLAS A.P. BROWN, CYRIL A. CLARKE, A.J. COAKLEY, DESMOND N. CROFT, A.F. DEUTMAN, J.A. DRAEGER, W. ERNST, PETER FELLS, STUART L. FINE, WALLACE S. FOULDS, BRIAN HARCOURT, RUTH VAN HEYNINGEN, A.L. HOLDEN, K. JESSEN, BARRIE R. JONES, HERBERT E. KAUFMAN, J. KELSEY, COLIN M. KEMP, G.A.S. LLOYD, JOHN MARSHALL, ROBERTA L. MEYERS, ISAAC C. MICHAELSON, STEPHEN J.H. MILLER, BRANKO NIZETIC, D.A. PALMER, J.C. PASHLEY, ARNALL PATZ, A.R. PETTIGREW, AMJAD, H.S. RAHI, EMANUEL ROSEN, M.D. SANDERS, EMIL S. SHERRARD, VERNON H. SMITH, KIRSTI H. TAKKI, DAVID TAYLOR, RAMESH C. TRIPATHI, MARCOS TSACOPOULOS, G. VENKATASWAMY, J.O. Williams, A.F. WINDER, J.C. WOODROW, K.C. WYBAR, YUVAL YASSUR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210fd03fee6ebff892a79769a40d9cea
https://doi.org/10.1016/b978-0-12-800341-1.09992-7

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Pharmacokinetics of Acyclovir after Single Intravenous and Oral Administration to Adult Horses

Autor: Bradford G. Bentz, Michael S. Davis, Lara K. Maxwell, Ronald S. Erkert, Cyril R. Clarke, Christopher M. Royer, Charles G. MacAllister

Publikováno v: Journal of Veterinary Internal Medicine. 20:589-594

The purpose of the study reported here was to describe the bioavailability and pharmacokinetics of acyclovir after intravenous and oral administration to horses. Six healthy adult horses were used in a randomized cross-over study with a 3×3 Latin sq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::735ce3c3f381f6ca28c6e5afa5e0daf9
https://doi.org/10.1111/j.1939-1676.2006.tb02901.x

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Ocular penetration of oral doxycycline in the horse

Autor: Jacqueline M. Dedeo, Martin Pugh, Margi A. Gilmour, David L. Caudell, Charles G. MacAllister, Rebecca J. Morton, Cyril R. Clarke

Publikováno v: Veterinary Ophthalmology. 8:331-335

Objective To investigate intraocular penetration of orally administered doxycycline in the normal equine eye and to compare intraocular and serum doxycycline concentrations. Procedures Six mares were administered doxycycline at 10 mg/kg every 12 h by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8a99f3706e52beb61ee15b5376bf71
https://doi.org/10.1111/j.1463-5224.2005.00422.x

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Karyotype Evolution by Chromosome Fusion in the Moth Genus Orgyia

Autor: Cyril A. Clarke, Walther Traut

Publikováno v: Hereditas. 126:77-84

Chromosome numbers vary greatly in Orgyiu, from low numbers, like n = 11 in 0. thyellina and n = 14 in 0. antiqua, to a high number, n = 30, as in 0. recens and 0. ericue. Meiotic synapsis was regular in 0. thyellina and 0. antiqua; 11 and 14 normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08681d572c56143beb798e71dfd466a8
https://doi.org/10.1111/j.1601-5223.1997.00077.x

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Cytogenetics of a Moth Species with a Low Chromosome Number, Orgyia Thyellina

Autor: Cyril A. Clarke, Walther Traut

Publikováno v: Hereditas. 125:277-283

While most Lepidoptera have numerous small chromosomes, Orgyia thyellina has few (n = 11) and relatively big chromosomes. We exploited this situation in a light microscopic study of chromosome morphology in mitosis and in various stages of male and f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17650595e452c9f139a8f6956cf5e8b2
https://doi.org/10.1111/j.1601-5223.1996.00277.x

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Development of an ex vivo model to study adherence of Mannheimia haemolytica serovar 1 to mucosal tissues of the respiratory tract of cattle

Autor: Rebecca J. Morton, Jeremiah T. Saliki, Cyril R. Clarke, Jean M. Clarke, Robert W. Fulton

Publikováno v: American Journal of Veterinary Research. 62:805-811

Objective—To develop and validate an ex vivo model for study of adherence ofMannheimia haemolytica(formerlyPasteurella haemolytica) to respiratory tract mucosa of cattle and to use this model to confirm adherence ofM haemolyticaserovar 1 (Mh1) to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e72554c2cbb4c3bf840e86141127a2
https://doi.org/10.2460/ajvr.2001.62.805

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INTRAVENOUS PHARMACOKINETICS OF PENICILLIN G AND ANTIPYRINE IN OSTRICHES (DROMAIUS NOVAEHOLLANDIAE)

Autor: Zuncai Wang, A. Alan Kocan, Alistair I. Webb, Cyril R. Clarke, Laura Cudd

Publikováno v: Journal of Zoo and Wildlife Medicine. 32:74-77

Penicillin G and antipyrine, which served as model drugs to assess the relative capacities of renal and hepatic elimination pathways, respectively, were each administered intravenously to six ostriches (Struthio camelus) and to six emus (Dromaius nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47bd51d55bcea0efdf9606b18e7e4ab1
https://doi.org/10.1638/1042-7260(2001)032[0074:ipopga]2.0.co

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