Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Cynthia Yu‐Wai‐Man"'
Autor:
Jinyuan Luo, Greymi Tan, Kai Xin Thong, Konstantinos N. Kafetzis, Neeru Vallabh, Carl M. Sheridan, Yusuke Sato, Hideyoshi Harashima, Aristides D. Tagalakis, Cynthia Yu-Wai-Man
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2472 (2022)
The primary cause of failure for minimally invasive glaucoma surgery (MIGS) is fibrosis in the trabecular meshwork (TM) that regulates the outflow of aqueous humour, and no anti-fibrotic drug is available for intraocular use in MIGS. The myocardin-re
Externí odkaz:
https://doaj.org/article/f81134b72765434d8df5ccafcd8d7fdb
Autor:
Aristides D. Tagalakis, Shivam Madaan, Scott D. Larsen, Richard R. Neubig, Peng T. Khaw, Ian Rodrigues, Saurabh Goyal, Kin Sheng Lim, Cynthia Yu-Wai-Man
Publikováno v:
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Sustained drug delivery is a large unmet clinical need in glaucoma. Here, we incorporated a Myocardin-Related Transcription Factor/Serum Response Factor inhibitor, CCG-222740, into slow release large unilamellar vesicles derived f
Externí odkaz:
https://doaj.org/article/01cbae81bc8b41f7bd5ccf2d64ab173f
Autor:
Cynthia Yu-Wai-Man, Nicholas Owen, Jonathan Lees, Aristides D. Tagalakis, Stephen L. Hart, Andrew R. Webster, Christine A. Orengo, Peng T. Khaw
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Fibrosis-related events play a part in most blinding diseases worldwide. However, little is known about the mechanisms driving this complex multifactorial disease. Here we have carried out the first genome-wide RNA-Sequencing study in human
Externí odkaz:
https://doaj.org/article/5c0371687dca468ab80f8f19c7cf2ac1
Autor:
Cynthia Yu-Wai-Man, Bradley Spencer-Dene, Richard M. H. Lee, Kim Hutchings, Erika M. Lisabeth, Richard Treisman, Maryse Bailly, Scott D. Larsen, Richard R. Neubig, Peng T. Khaw
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a precl
Externí odkaz:
https://doaj.org/article/d0d09e6ee5ac462a80dbec12fafe4e2c
Autor:
Amisha Sanghani, Konstantinos N. Kafetzis, Yusuke Sato, Salsabil Elboraie, Julia Fajardo-Sanchez, Hideyoshi Harashima, Aristides D. Tagalakis, Cynthia Yu-Wai-Man
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 382 (2021)
The master regulator of the fibrosis cascade is the myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway, making it a key target for anti-fibrotic therapeutics. In the past, inhibitors and small interfering RNAs (siRNAs) ta
Externí odkaz:
https://doaj.org/article/07127ab760884d819d2549c43fd55a13
Autor:
Cynthia Yu-Wai-Man, Fiona E Smith, Michael J Firbank, Grant Guthrie, Stuart Guthrie, Grainne S Gorman, Robert W Taylor, Douglass M Turnbull, Philip G Griffiths, Andrew M Blamire, Patrick F Chinnery, Patrick Yu-Wai-Man
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75048 (2013)
BACKGROUND:Chronic progressive external ophthalmoplegia (CPEO) is a classical mitochondrial ocular disorder characterised by bilateral progressive ptosis and ophthalmoplegia. These ocular features can develop either in isolation or in association wit
Externí odkaz:
https://doaj.org/article/c3ae48de056b4d14bd3a5a7422450772
Autor:
Nicole Ioannou, Jinyuan Luo, Mengqi Qin, Matteo Di Luca, Essyrose Mathew, Aristides D Tagalakis, Dimitrios A Lamprou, Cynthia Yu-Wai-Man
Publikováno v:
Ioannou, N, Luo, J, Qin, M, Di Luca, M, Mathew, E, Tagalakis, A D, Lamprou, D A & Yu-Wai-Man, C 2023, ' 3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma ', Journal of Pharmacy and Pharmacology, vol. 75, no. 2, pp. 276-286 . https://doi.org/10.1093/jpp/rgac100
Objectives To develop a sustained release 5-fluorouracil (5-FU) implant by three-dimensional (3D) printing to effectively prevent conjunctival fibrosis after glaucoma surgery. Methods 3D-printed implants composed of polycaprolactone (PCL) and chitosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b270e18648a6da54b172bf5b809a30c7
https://doi.org/10.1093/jpp/rgac100
https://doi.org/10.1093/jpp/rgac100
Autor:
Elizabeth Galvis, Arij Daas, Andrew Amon, Kin Sheng Lim, Lina Danieliute, Cynthia Yu-Wai-Man, Anindyt Nagar, Pouya Alaghband
Publikováno v:
Eye (Lond)
Purpose High intensity focused ultrasound (HiFU) is a cyclodestructive therapy for controlling intraocular pressure (IOP) in glaucoma. The mechanism of action is thought to be through destruction of the ciliary epithelium as well as increased uveoscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351fbf9efb5b657de01188dcead286a7
https://doi.org/10.1038/s41433-020-01260-9
https://doi.org/10.1038/s41433-020-01260-9
Autor:
Tejal Magan, Alexander Tanner, Julia Fajardo-Sanchez, Kin Sheng Lim, Saurabh Goyal, Ian Rodrigues, Luis Amaya, Sameer Trikha, Avinash Kulkarni, Christopher Hammond, Gerassimos Lascaratos, Cynthia Yu-Wai-Man
Publikováno v:
European journal of ophthalmology. 32(5)
Aim To determine the long-term outcomes of a cohort of complex patients with primary congenital glaucoma, aniridia and anterior segment dysgenesis. Methods Retrospective consecutive series between 1990–2021 in two UK tertiary centres: Guy's and St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e8dc855943404666a78c37e98d8a97
https://pubmed.ncbi.nlm.nih.gov/35001688
https://pubmed.ncbi.nlm.nih.gov/35001688
Autor:
Konstantinos N. Kafetzis, Natalia Papalamprou, Elisha McNulty, Kai X. Thong, Yusuke Sato, Aleksandr Mironov, Atul Purohit, Philip J. Welsby, Hideyoshi Harashima, Cynthia Yu‐Wai‐Man, Aristides D. Tagalakis
Publikováno v:
Advanced Healthcare Materials. :2203022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cc53ac5a1b62244d316febfe2322d8
https://doi.org/10.1002/adhm.202203022
https://doi.org/10.1002/adhm.202203022