Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Cynthia Tuthill"'
Autor:
Cynthia Tuthill, Robert S. King
Publikováno v:
Expert Opinion on Biological Therapy. 15:41-49
Recent understanding of the complex pathophysiology of melanoma and severe sepsis suggests that immune-modulating compounds such as thymosin alpha 1 (INN: thymalfasin; abbreviated Ta1) could be useful in the treatment of these two unrelated immune-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0459985be7baf9504190a9ac78f9ff9a
https://doi.org/10.1517/14712598.2015.1008446
https://doi.org/10.1517/14712598.2015.1008446
Publikováno v:
Annals of the New York Academy of Sciences. 1270:21-27
Thymosin α1 (Tα1) is an immune-modulating peptide that can be expected to improve response to vaccinations, as stimulated dendritic cells and T cells can act in concert to increase antibody production along with an improved cytotoxic response from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc95f35e96ba341cde04fab2b456b448
https://doi.org/10.1111/j.1749-6632.2012.06680.x
https://doi.org/10.1111/j.1749-6632.2012.06680.x
Publikováno v:
Annals of the New York Academy of Sciences. 1194:130-135
Thymosin alpha 1, originally isolated as the compound responsible for reconstitution of immune function in thymectomized animal models, has enjoyed a wide-ranging clinical development program over the past decades, extending across multiple companies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e8949e8e18561aff5e86b7a80de84be
https://doi.org/10.1111/j.1749-6632.2010.05482.x
https://doi.org/10.1111/j.1749-6632.2010.05482.x
Autor:
Cynthia Tuthill, Nikolai I. Kolodkin, Yury A. Zolotarev, Elena V. Navolotskaya, Kolobov Alexander A
Publikováno v:
International Journal of Peptide Research and Therapeutics. 14:97-103
Tritium-labeled dipeptide bestim (γ-D-Glu-L-Trp) with a specific activity of 45 Ci/mmol was obtained by the high-temperature solid-state catalytic isotope exchange (HSCIE) reaction. [3H]bestim was found to bind with high affinity to mouse peritoneal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eba3989905039b26985178922f344e1e
https://doi.org/10.1007/s10989-007-9111-2
https://doi.org/10.1007/s10989-007-9111-2
Publikováno v:
Peptides. 23:1011-1014
The effects of thymosin alpha1 (Talpha1) on mammary carcinogenesis was investigated in Fisher rats. Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats. Daily administration of Talpha1 (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7536f8bc8043d609f915388c81e1a9f8
https://doi.org/10.1016/s0196-9781(02)00025-6
https://doi.org/10.1016/s0196-9781(02)00025-6
Autor:
Mary E. Teresi, Mark R. Weatherly, Kathleen A. Hilliard, Janice L. Launspach, Richard C. Ahrens, Moira L. Aitken, Nael A. McCarty, Warren E. Regelmann, Michael W. Konstan, Thomas A. Standaert, Cynthia Tuthill, Thomas J. Kelley, Laura J H Milgram
Publikováno v:
Pediatric Pulmonology. 33:90-98
CPX (8-cyclopentyl-1,3-dipropylxanthine) is a novel compound currently under development as a potential treatment for cystic fibrosis (CF). The drug has been shown to increase chloride efflux and CFTR trafficking in vitro in CF airway cells. This pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12130711e73722ebdaa259e39458813f
https://doi.org/10.1002/ppul.10041
https://doi.org/10.1002/ppul.10041
Autor:
Robert S. King, Cynthia Tuthill
Publikováno v:
Clinical & Experimental Pharmacology.
Objectives: To investigate the pharmacokinetics of Carbamazepine (CBZ) in rats during growth hormone treatment. Methods: Recombinant Human Growth Hormone (rhGH) was injected subcutaneously at a daily dose of 0.1 mg/ kg, 2 mg/kg, or phosphate buffered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b73926d73c0d56dc22ae0f5191c5ac97
https://doi.org/10.4172/2161-1459.1000133
https://doi.org/10.4172/2161-1459.1000133
Publikováno v:
Annals of the New York Academy of Sciences. 1270
Thymosin α1 (Tα1) is an immune-modulating peptide that can be expected to improve response to vaccinations, as stimulated dendritic cells and T cells can act in concert to increase antibody production along with an improved cytotoxic response from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5f38a5542d5edae3efff115464db40f
https://pubmed.ncbi.nlm.nih.gov/23050813
https://pubmed.ncbi.nlm.nih.gov/23050813
Publikováno v:
Annals of the New York Academy of Sciences. 1194
Thymosin alpha 1, originally isolated as the compound responsible for reconstitution of immune function in thymectomized animal models, has enjoyed a wide-ranging clinical development program over the past decades, extending across multiple companies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1af7386b1572d5aaed6e35f508ddea9f
https://pubmed.ncbi.nlm.nih.gov/20536460
https://pubmed.ncbi.nlm.nih.gov/20536460
Publikováno v:
International journal of antimicrobial agents. 32(3)
Herpes simplex virus type 2 (HSV-2) infections produce a recurrent disease state associated with susceptibility to other pathogens, including human immunodeficiency virus (HIV), and cannot be cured by current therapeutic treatments. The HSV-2 epidemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03e90d25826da77cb27799a7522b5f1
https://pubmed.ncbi.nlm.nih.gov/18619817
https://pubmed.ncbi.nlm.nih.gov/18619817