Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Cynthia T. McMurray"'
Autor:
Aris A. Polyzos, Ana Cheong, Jung Hyun Yoo, Lana Blagec, Sneh M. Toprani, Zachary D. Nagel, Cynthia T. McMurray
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract We lack the fundamental information needed to understand how DNA damage in the brain is generated and how it is controlled over a lifetime in the absence of replication check points. To address these questions, here, we integrate cell-type a
Externí odkaz:
https://doaj.org/article/d747a9112a0b4d0da581a69cc8f5ea6f
Autor:
Lila Lovergne, Dhruba Ghosh, Renaud Schuck, Aris A. Polyzos, Andrew D. Chen, Michael C. Martin, Edward S. Barnard, James B. Brown, Cynthia T. McMurray
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Although some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack methods to predict who has developed disease before the onset of symptoms, when onset will occ
Externí odkaz:
https://doaj.org/article/846890e2041e4915b5b464f2f470d9da
Autor:
Yanhao Lai, Helen Budworth, Jill M. Beaver, Nelson L. S. Chan, Zunzhen Zhang, Cynthia T. McMurray, Yuan Liu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The expansion of trinucleotide repeats can have detrimental effects and give rise to a range of human diseases. Here the authors report that the mismatch repair and the base excision repair machinery can operate together to promote expansion during l
Externí odkaz:
https://doaj.org/article/3879ba8a8aee40aca671630c5cc0af1e
Autor:
Zhiyin Xun, Sulay Rivera-Sánchez, Sylvette Ayala-Peña, James Lim, Helen Budworth, Erin M. Skoda, Paul D. Robbins, Laura J. Niedernhofer, Peter Wipf, Cynthia T. McMurray
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1137-1142 (2012)
Oxidative damage and mitochondrial dysfunction are implicated in aging and age-related neurodegenerative diseases, including Huntington’s disease (HD). Many naturally occurring antioxidants have been tested for their ability to correct for deleteri
Externí odkaz:
https://doaj.org/article/501e326a320a4a2ab2c9aa10fc82e60e
Autor:
Lars Eide, Cynthia T. McMurray
Publikováno v:
BioTechniques, Vol 38, Iss 1, Pp 99-104 (2005)
Primary neuronal cells used to model physiology are generally limited to embryonic tissue. However, embryonic tissue is not optimal as a model for age-related changes in physiology or late-onset disease. Successful culturing of neurons from adult ani
Externí odkaz:
https://doaj.org/article/7460f18e1ca24c45a162c8404720dbc9
Publikováno v:
BioTechniques, Vol 25, Iss 1, Pp 68-72 (1998)
We observed an apparent series of insertions and deletions beginning 5 bp downstream of an A→G silent transition in exon 1 of the tumor necrosis factor receptor 1 gene. The apparent sequence anomaly was observed only in individuals carrying the tra
Externí odkaz:
https://doaj.org/article/d1499a8a91544487bcc29e0865919538
Publikováno v:
Journal of Huntington's disease, vol 11, iss 1
Due to large increases in the elderly populations across the world, age-related diseases are expected to expand dramatically in the coming years. Among these, neurodegenerative diseases will be among the most devastating in terms of their emotional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e34930b7abfad54fa0750283e3b600
https://doi.org/10.3233/jhd-210510
https://doi.org/10.3233/jhd-210510
Publikováno v:
J Huntingtons Dis
Background: Mitochondria (MT) are energy “powerhouses” of the cell and the decline in their function from oxidative damage is strongly correlated in many diseases. To suppress oxygen damage, we have developed and applied XJB-5-131 as a targeted p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afd670b6e5a75183bb6bb3991606da9
https://pubmed.ncbi.nlm.nih.gov/35404288
https://pubmed.ncbi.nlm.nih.gov/35404288
Autor:
Eduardo E. Laverde, Aris A. Polyzos, Pawlos P. Tsegay, Mohammad Shaver, Joshua D. Hutcheson, Lata Balakrishnan, Cynthia T. McMurray, Yuan Liu
Publikováno v:
Genes; Volume 14; Issue 1; Pages: 98
Flap endonuclease 1 (FEN1) is an essential enzyme that removes RNA primers and base lesions during DNA lagging strand maturation and long-patch base excision repair (BER). It plays a crucial role in maintaining genome stability and integrity. FEN1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d618fb019c0ef7bfdbb2d712dbd594
https://doi.org/10.3390/genes14010098
https://doi.org/10.3390/genes14010098
Autor:
Aris Polyzos, Dhruba Ghosh, Lila Lovergne, Renaud Schuck, Edward S. Barnard, James B. Brown, Michael C. Martin, Andrew D. Chen, Cynthia T. McMurray
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Although some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack methods to predict who has developed disease before the onset of symptoms, when onset will occur, or th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde61bed6618f788580805954b312a76
https://escholarship.org/uc/item/58m3f68f
https://escholarship.org/uc/item/58m3f68f
