Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length

Autor: Cynthia Seiler, Julie P.I. Welburn, Clara Nahmias, Damarys Loew, Marin Barisic, Anne Nehlig, Claude Prigent, Yulia Steblyanko, Florent Dingli, Guillaume Arras

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (4), pp.1765-1779. ⟨10.1007/s00018-020-03614-8⟩
Nehlig, A, Seiler, C, Steblyanko, Y, Dingli, F, Arras, G, Loew, D, Welburn, J, Prigent, C, Barisic, M & Nahmias, C 2021, ' Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length ', Cellular and Molecular Life Sciences, vol. 78, pp. 1765–1779 . https://doi.org/10.1007/s00018-020-03614-8
Cellular and Molecular Life Sciences, 2021, 78 (4), pp.1765-1779. ⟨10.1007/s00018-020-03614-8⟩
Nehlig, A, Seiler, C, Steblyanko, Y, Dingli, F, Arras, G, Loew, D, Welburn, J, Prigent, C, Barisic, M & Nahmias, C 2020, ' Reciprocal regulation of aurora kinase A and ATIP3 in the control of metaphase spindle length ', Cellular and Molecular Life Sciences . https://doi.org/10.1007/s00018-020-03614-8

International audience; Maintaining the integrity of the mitotic spindle in metaphase is essential to ensure normal cell division. We show here that depletion of microtubule-associated protein ATIP3 reduces metaphase spindle length. Mass spectrometry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cccece88ad7208e691552c8d7aef2b
https://hal.archives-ouvertes.fr/hal-02924786

Improving breast cancer sensitivity to paclitaxel by increasing aneuploidy

Autor: Magali Lacroix-Triki, Clara Nahmias, Jean-Yves Pierga, Elisabetta Marangoni, Marie-Eglantine Dujaric, Patricia de Cremoux, Nicolas Servant, Bernard Asselain, Fabrice Andre, Cynthia Seiler, Monica Arnedos, Sylvie Rodrigues-Ferreira, Clarisse Monchecourt, Sophie Chateau-Joubert, Hadia Moindjie, Anne Nehlig

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (47), pp.23691-23697. ⟨10.1073/pnas.1910824116⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (47), pp.23691-23697. ⟨10.1073/pnas.1910824116⟩

International audience; Predictive biomarkers for tumor response to neoadjuvant chemotherapy are needed in breast cancer. This study investigates the predictive value of 280 genes encoding proteins that regulate microtubule assembly and function. By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baca692b7dbb1befa05d67809af1e229
https://hal-univ-tlse2.archives-ouvertes.fr/hal-02411561/document

Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity

Autor: Clément Bernaudin, Nicolas Borghi, Charlène Gayrard, Théophile Déjardin, Cynthia Seiler

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (3), pp.1063-1077. ⟨10.1083/jcb.201706013⟩
The Journal of Cell Biology

β-Catenin is a transcription cofactor proposed to be released from E-cadherin upon mechanically induced phosphorylation. However, evidence for this mechanism is lacking. Gayrard et al. show instead that during epithelial-to-mesenchymal transition, S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ee2182a7f1d82eda1d4ff57fea6892
https://hal.archives-ouvertes.fr/hal-02325376