Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Cynthia S. Spittle"'
Publikováno v:
Cancer Research. 79:1702-1702
PD-L1 expression and MSI status are useful predictive biomarkers for checkpoint inhibitors (CIs) in some tumor types. However, studies have demonstrated that the identification of all potential patients who may benefit from CIs will require the analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15e80f3024c88c653e298ec4d44ae50
https://doi.org/10.1158/1538-7445.am2019-1702
https://doi.org/10.1158/1538-7445.am2019-1702
Autor:
Cynthia S. Spittle, Christiana M. Shaw, Brian L. Egleston, Joanne F. Dorgan, Frank Z. Stanczyk, L L Kahle, Andrew K. Godwin, Louise A. Brinton
Publikováno v:
Fertility and Sterility. 95:2718-2721
Antimüllerian hormone (AMH) is extensively studied in ovarian aging and pathology; however, little is known about correlates in healthy premenopausal women. We found that AMH levels are strongly inversely associated with age and differed significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ebc4a88da62b0846da1880f9ee55d1
https://doi.org/10.1016/j.fertnstert.2011.05.051
https://doi.org/10.1016/j.fertnstert.2011.05.051
Publikováno v:
Cancer Research. 78:3614-3614
Checkpoint inhibitors have been approved for the treatment of solid tumor and hematological malignancies. While significant responses have been observed in a subset of patients, outcomes are variable and there is a need to identify additional predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db52516848ace4efb00d409d95942378
https://doi.org/10.1158/1538-7445.am2018-3614
https://doi.org/10.1158/1538-7445.am2018-3614
Publikováno v:
Journal of Investigative Dermatology. 128:980-987
The objective of this study was to determine whether activation of the kinase mammalian target of rapamycin (mTOR) is associated with human melanoma. We found moderate or strong hyperphosphorylation of ribosomal protein S6 in 78/107 melanomas (73%).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58327985638688058be86ab6e7063d18
https://doi.org/10.1038/sj.jid.5701074
https://doi.org/10.1038/sj.jid.5701074
Autor:
Wen-Chi L. Chang, Renata A. Coudry, Kara-Lynn Williams, Tianyu Li, Xiaoyan Zhang, Harry S. Cooper, Cynthia S. Spittle, Margie L. Clapper
Publikováno v:
Carcinogenesis. 28:2375-2381
Loss of p53 function is an early event in colitis-associated neoplasia in humans. We assessed the role of p53 in a mouse model of colitis-associated neoplasia. Colitis was induced in p53-/-, p53+/- and p53+/+ mice using three or four cycles of dextra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d7dbe413eabe5e711b4842de258c4e
https://doi.org/10.1093/carcin/bgm134
https://doi.org/10.1093/carcin/bgm134
Autor:
Margie L. Clapper, Lynette C. Everley, Wen-Chi L. Chang, Monique A. Gary, Hao Wang, Harry S. Cooper, Cynthia S. Spittle, Renata A. Coudry, Sam Litwin
Publikováno v:
Molecular Carcinogenesis. 44:31-41
The relevance of the Apc(+/Min) mouse model in the study of human colorectal cancer remains uncertain due to the predominance of small intestinal adenomas and few, if any, colorectal adenomas. A new strain of Apc(+/Min) mice (Apc(+/Min-FCCC)) with si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733e782d1935a739269ccd4d9744bf33
https://doi.org/10.1002/mc.20114
https://doi.org/10.1002/mc.20114
Autor:
Lisa Kahle, Joanne F. Dorgan, Cynthia S. Spittle, Frank Z. Stanczyk, Andrew K. Godwin, Christiana M. Shaw, Brian L. Egleston, Louise A. Brinton
Publikováno v:
JNCI Journal of the National Cancer Institute
BACKGROUND Mullerian inhibiting substance (MIS) is a member of the transforming growth factor beta family of growth and differentiation factors that inhibits elongation and branching of mammary ducts and has been shown to inhibit mammary tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6853375ee905978e2827233dfd2365
https://pubmed.ncbi.nlm.nih.gov/19820206
https://pubmed.ncbi.nlm.nih.gov/19820206
Autor:
Ruzaliya Fazlieva, Cynthia S. Spittle, Darlene Morrissey, Hong Yan, Yoshihiro Matsumoto, Harutoshi Hayashi
Publikováno v:
Nucleic Acids Research
Replicative DNA polymerases possess 3' --> 5' exonuclease activity to reduce misincorporation of incorrect nucleotides by proofreading during replication. To examine if this proofreading activity modulates DNA synthesis of damaged templates, we const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4921249832a29735036f10424a44e5
https://pubmed.ncbi.nlm.nih.gov/19282447
https://pubmed.ncbi.nlm.nih.gov/19282447
Autor:
Daniel J. Berg, Peter J. O'Dwyer, S. N. Holden, Sara Kenkare-Mitra, Lu Xu, Neal J. Meropol, Rebecca L. Blanchard, Cynthia S. Spittle, Anne Kearns, Andrew Dorr, Coen Bernaards, Julie Hambleton, Susan McLaughlin, Crystal S. Denlinger, Samuel Litwin, Bert L. Lum, Maryann Redlinger
Publikováno v:
Cancer chemotherapy and pharmacology. 65(1)
The purpose of this study was to evaluate the effect of bevacizumab on the pharmacokinetics (PK) of irinotecan and its active metabolite. Exploratory analyses of the impact of variability in uridine diphosphate glucuronosyltransferase 1A (UGT1A) gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892c80be64aebaa869377a8017257e80
https://pubmed.ncbi.nlm.nih.gov/19415281
https://pubmed.ncbi.nlm.nih.gov/19415281
Autor:
Cynthia S. Spittle, M. Renee Ward, Robin H. Edwards, Eric F. Rappaport, Angelica Medina, Phyllis A. Gimotty, Marcia S. Brose, Meenhard Herlyn, Richard Letrero, Katherine L. Nathanson
Publikováno v:
The Journal of molecular diagnostics : JMD. 9(4)
Mutations in the BRAF gene are found in the majority of cutaneous malignant melanomas and subsets of other tumors. These mutations lead to constitutive activation of BRAF with increased downstream ERK (extracellular signal-regulated kinase) signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f40062e4378952e6a48ee39614ccb5f
https://pubmed.ncbi.nlm.nih.gov/17690212
https://pubmed.ncbi.nlm.nih.gov/17690212