Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Cynthia S. Dowd"'
Autor:
Misgina B. Girma, Haley S. Ball, Xu Wang, Robert C. Brothers, Emily R. Jackson, Marvin J. Meyers, Cynthia S. Dowd, Robin D. Couch
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 27630-27639 (2021)
Externí odkaz:
https://doaj.org/article/5f9312837951499b909e15c7c9b48c54
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients w
Externí odkaz:
https://doaj.org/article/6ba46a8f9e2e4e268c882c0b74a0fe30
Autor:
Rachel L. Edwards, Robert C. Brothers, Xu Wang, Maxim I. Maron, Peter D. Ziniel, Patricia S. Tsang, Thomas E. Kraft, Paul W. Hruz, Kim C. Williamson, Cynthia S. Dowd, Audrey R. Odom John
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the met
Externí odkaz:
https://doaj.org/article/539d6d0aabfc46c68f5a489b64e29fac
Autor:
René Chofor, Martijn D.P. Risseeuw, Jenny Pouyez, Chinchu Johny, Johan Wouters, Cynthia S. Dowd, Robin D. Couch, Serge Van Calenbergh
Publikováno v:
Molecules, Vol 19, Iss 2, Pp 2571-2587 (2014)
Fourteen new fosmidomycin analogues with altered metal chelating groups were prepared and evaluated for inhibition of E. coli Dxr, M. tuberculosis Dxr and the growth of P. falciparum K1 in human erythrocytes. None of the synthesized compounds showed
Externí odkaz:
https://doaj.org/article/8b6c2ff6d29546bab759a0b9b53936b3
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul Planet, Florian L Muller, Joseph Jez, Audrey R Odom John
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/98f3fd68d1a542c2816442fd7398b063
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Publikováno v:
eLife, Vol 10 (2021)
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However,
Externí odkaz:
https://doaj.org/article/17f733fe025245b6a2dbe45ff732edb9
Autor:
Samuel A. Kirby, Cynthia S. Dowd
Publikováno v:
Med Chem Res
Phosphoryl prodrugs are key compounds in drug development. Biologically active phosphoryl compounds often have negative charges on the phosphoryl group, and as a result, frequently have poor pharmacokinetic (PK) profiles. The use of lipophilic moieti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7106c5d00337d43d0711b47e9b13918a
https://doi.org/10.1007/s00044-021-02766-x
https://doi.org/10.1007/s00044-021-02766-x
Autor:
R. Jeremy Johnson, Elizabeth A. Mueller, Jayda Hatten, Joseph M. Jez, Rachel L. Edwards, Geoffrey C. Hoops, Ahmed M Moustafa, Florian L. Muller, Ishaan T. Shah, Yasaman Barekatain, Cynthia S. Dowd, Paul J. Planet, Audrey R. Odom John, Justin J. Miller
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c74c98727b666ca172619baae03b4cb
https://elifesciences.org/articles/75743
https://elifesciences.org/articles/75743
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3534ca2a868485ac544a6892c6799f4d
https://doi.org/10.7554/elife.66657.sa2
https://doi.org/10.7554/elife.66657.sa2
Autor:
Cynthia S. Dowd, Kenneth M. Heidel
Publikováno v:
Future Med Chem
Phosphonates, often used as isosteric replacements for phosphates, can provide important interactions with an enzyme. Due to their high charge at physiological pH, however, permeation into cells can be a challenge. Protecting phosphonates as prodrugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a149d7eb8911abdc4f85d475f10ab53
https://doi.org/10.4155/fmc-2018-0591
https://doi.org/10.4155/fmc-2018-0591