Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Cynthia S Dowd"'
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul Planet, Florian L Muller, Joseph Jez, Audrey R Odom John
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/98f3fd68d1a542c2816442fd7398b063
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Publikováno v:
eLife, Vol 10 (2021)
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However,
Externí odkaz:
https://doaj.org/article/17f733fe025245b6a2dbe45ff732edb9
Autor:
Rachel L Edwards, Isabel Heueck, Soon Goo Lee, Ishaan T Shah, Justin J Miller, Andrew J Jezewski, Marwa O Mikati, Xu Wang, Robert C Brothers, Kenneth M Heidel, Damon M Osbourn, Carey-Ann D Burnham, Sophie Alvarez, Stephanie A Fritz, Cynthia S Dowd, Joseph M Jez, Audrey R Odom John
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1007806 (2020)
Coagulase-positive staphylococci, which frequently colonize the mucosal surfaces of animals, also cause a spectrum of opportunistic infections including skin and soft tissue infections, urinary tract infections, pneumonia, and bacteremia. However, re
Externí odkaz:
https://doaj.org/article/5dc53d519c85411dae65c54b8c5190b9
Autor:
Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106243 (2014)
The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone. Because mammals synthesize isoprenoids via an alternate pathway
Externí odkaz:
https://doaj.org/article/dd1996804d5d44a7a770cf35a3430aee
Autor:
Elizabeth S McKenney, Michelle Sargent, Hameed Khan, Eugene Uh, Emily R Jackson, Géraldine San Jose, Robin D Couch, Cynthia S Dowd, Monique L van Hoek
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e38167 (2012)
Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells. The
Externí odkaz:
https://doaj.org/article/06a91359bad242128ad771b2c63ac854
Autor:
Misgina B. Girma, Haley S. Ball, Xu Wang, Robert C. Brothers, Emily R. Jackson, Marvin J. Meyers, Cynthia S. Dowd, Robin D. Couch
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 42, Pp 27630-27639 (2021)
ACS Omega, Vol 6, Iss 42, Pp 27630-27639 (2021)
Malaria is a global health threat that requires immediate attention. Malaria is caused by the protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum. The methylerythritol phosphate (MEP) pathway of isoprenoid biosynthes
Autor:
Samuel A. Kirby, Cynthia S. Dowd
Publikováno v:
Med Chem Res
Phosphoryl prodrugs are key compounds in drug development. Biologically active phosphoryl compounds often have negative charges on the phosphoryl group, and as a result, frequently have poor pharmacokinetic (PK) profiles. The use of lipophilic moieti
Autor:
R. Jeremy Johnson, Elizabeth A. Mueller, Jayda Hatten, Joseph M. Jez, Rachel L. Edwards, Geoffrey C. Hoops, Ahmed M Moustafa, Florian L. Muller, Ishaan T. Shah, Yasaman Barekatain, Cynthia S. Dowd, Paul J. Planet, Audrey R. Odom John, Justin J. Miller
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However,
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3534ca2a868485ac544a6892c6799f4d
https://doi.org/10.7554/elife.66657.sa2
https://doi.org/10.7554/elife.66657.sa2
Autor:
Cynthia S. Dowd, Kenneth M. Heidel
Publikováno v:
Future Med Chem
Phosphonates, often used as isosteric replacements for phosphates, can provide important interactions with an enzyme. Due to their high charge at physiological pH, however, permeation into cells can be a challenge. Protecting phosphonates as prodrugs