Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Cynthia R. Willis"'
Autor:
Maarten R Hillen, Sarita A Y Hartgring, Cynthia R Willis, Timothy R D J Radstake, Cornelis E Hack, Floris P J G Lafeber, Joel A G van Roon
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130830 (2015)
The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) signal through the IL-7R subunit and play proinflammatory roles in experimental arthritis and rheumatoid arthritis (RA). We evaluated the effect of inhibition of IL-7R- and TSLP
Externí odkaz:
https://doaj.org/article/38c9e1e0a57a40579904cb010d2ea864
Autor:
Sharon Wannberg, James B. Rottman, Sabine S. Escobar, Joel Tocker, Daniela Metz, Michael R. Comeau, Deanna Mohn, Kira Misura, Alison L. Budelsky, Anh Leith, Erika Rickel, Lori Siegel, John K. Sullivan, Cynthia R. Willis
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:810-821
Asthma is a heterogeneous disease characterized by airway inflammation and hyperreactivity. IL-17 receptor A (IL-17RA) is a shared receptor subunit required for activity of IL-17 family cytokines, including IL-17A and IL-25. IL-17A and IL-25 induce d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78763ed5ddd89dd9cd34f2e246eb178f
https://doi.org/10.1165/rcmb.2015-0038oc
https://doi.org/10.1165/rcmb.2015-0038oc
Autor:
David Artis, Laurel A. Monticelli, Lisa C. Osborne, Cynthia R. Willis, Donna L. Farber, Joseph J.C. Thome, Alison L. Budelsky, E. D. Tait Wojno, Sara V. Tran, Theresa Alenghat
Publikováno v:
Mucosal immunology
Group 2 innate lymphoid cells (ILC2s) promote type 2 cytokine-dependent immunity, inflammation, and tissue repair. Although epithelial cell-derived cytokines regulate ILC2 effector functions, the pathways that control the in vivo migration of ILC2s i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a670f6a6814d79994777657ee5494e7f
http://europepmc.org/articles/PMC4598246
http://europepmc.org/articles/PMC4598246
Autor:
Cynthia R. Willis, Sarita A. Y. Hartgring, W. van Eden, C. E. Dean, J.A. van Roon, F.P.J.G. Lafeber, Femke Broere, Jwj Bijlsma
Publikováno v:
Arthritis & Rheumatism. 63:1878-1887
Objective The interleukin-7 (IL-7)–related cytokine thymic stromal lymphopoietin (TSLP) is a potent activator of myeloid dendritic cells, enhancing Th2-mediated hypersensitivity, and it has been implicated in the pathogenesis of atopic diseases. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe3f668bbc944dd52b4352f67138948
https://doi.org/10.1002/art.30336
https://doi.org/10.1002/art.30336
Autor:
Kim M. G. Jacobs, Floris P J G Lafeber, Joel A G van Roon, Marion Wenting-van Wijk, Johannes W. J. Bijlsma, Sarita A. Y. Hartgring, Cynthia R. Willis, Z. N. Jahangier
Publikováno v:
Arthritis & Rheumatism. 60:2595-2605
To evaluate the expression and functional ability of the high-affinity interleukin-7 receptor (IL-7Ralpha) in patients with rheumatoid arthritis (RA).Expression of IL-7Ralpha and IL-7 was determined in synovial tissue from RA patients and was compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6161ac8660c14763bfe3723c49de84
https://doi.org/10.1002/art.24754
https://doi.org/10.1002/art.24754
Autor:
Hal Blumberg, Esther S. Trueblood, Jennifer E. Towne, James Pretorius, Melanie K. Kuechle, David G. Kugler, Cynthia R. Willis, John E. Sims, Ning Weng, Huyen Dinh, Suzanne Kanaly, Jacques J. Peschon
Publikováno v:
The Journal of Experimental Medicine
The interleukin (IL)-1 family members IL-1α, -1β, and -18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Recently, several new IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d15ccac9d75a6b4df85a8d88cbfbe20
http://europepmc.org/articles/PMC2118475
http://europepmc.org/articles/PMC2118475
Autor:
Cynthia R. Willis, Timothy R D J Radstake, Cornelis E. Hack, Maarten R Hillen, Joel A G van Roon, Sarita A. Y. Hartgring, Floris P J G Lafeber
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0130830 (2015)
PLoS ONE [E], 10(6). Public Library of Science
PLoS ONE, Vol 10, Iss 6, p e0130830 (2015)
PLoS ONE [E], 10(6). Public Library of Science
Introduction: The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) signal through the IL-7R subunit and play proinflammatory roles in experimental arthritis and rheumatoid arthritis (RA). We evaluated the effect of inhibition of I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fc49669af0b7aeee0ccd542423657e
https://pubmed.ncbi.nlm.nih.gov/26110994
https://pubmed.ncbi.nlm.nih.gov/26110994
Autor:
J.Greg Murison, Annjanette S. Warren, Timothy A. Bird, Jonathan M.J. Derry, Keith Charrier, Moira Glaccum, Pamela M. Holland, Suzanne Kanaly, Jacques J. Peschon, Cynthia R. Willis, G. Duke Virca
Publikováno v:
Current Biology. 12(16):1424-1428
The epidermis is a stratified, continually renewing epithelium dependent on a balance among cell proliferation, differentiation, and death for homeostasis. In normal epidermis, a mitotically active basal layer gives rise to terminally differentiating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fa09bb2a7b4f62e905e680dcb88dc
Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
Autor:
Kim L. Stocking, Sandra N. Brown, Sebastian Joyce, Philip J. Morrissey, Monica E. Embers, Naoto Matsuki, Keith Charrier, Eric A. Butz, Lisa M. Sedger, Kenneth Brasel, Moira Glaccum, Jacques J. Peschon, JoAnn C. L. Schuh, Joanne L. Viney, Mary K. Kennedy, Cynthia R. Willis
Publikováno v:
The Journal of Experimental Medicine
C57BL/6 mice genetically deficient in interleukin 15 (IL-15−/− mice) were generated by gene targeting. IL-15−/− mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8+ T cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94442119fb9637300d5cb06846fc344b
https://doi.org/10.1084/jem.191.5.771
https://doi.org/10.1084/jem.191.5.771
TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation
Autor:
Jacques J. Peschon, Dauphine S. Torrance, Kim L. Stocking, Moira B. Glaccum, Carol Otten, Cynthia R. Willis, Keith Charrier, Philip J. Morrissey, Carol B. Ware, Kendall M. Mohler
Publikováno v:
The Journal of Immunology. 160:943-952
The pleiotropic activities of the potent proinflammatory cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and p75, that are coexpressed on most cell types. The majority of biologic responses classically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6f71c8b610a603a86ab4382bb25a68
https://doi.org/10.4049/jimmunol.160.2.943
https://doi.org/10.4049/jimmunol.160.2.943