Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Cynthia R. Timblin"'
Autor:
Jessica Gagne, Sally A. Huber, Naomi K. Fukagawa, Tara Sabo-Attwood, Douglas J. Taatjes, Muyao Li, Cynthia R. Timblin, Chad Steele, Brooke T. Mossman, Kelly J. Butnor
Publikováno v:
Environmental Health Perspectives
Background Associations between air pollution and morbidity/mortality from cardiovascular disease are recognized in epidemiologic and clinical studies, but the mechanisms by which inhaled fibers or particles mediate the exacerbation of atherosclerosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d886fe81dc6a6dd802bb9c1f16aa99b
http://europepmc.org/articles/PMC2535625
http://europepmc.org/articles/PMC2535625
Autor:
Cynthia R. Timblin, Naomi K. Fukagawa, Brooke T. Mossman, Muyao Li, Rui-Ming Liu, Suzanne G. Meyer
Publikováno v:
Journal of Cellular Physiology. 206:518-525
We previously reported that activator protein-1 (AP-1) DNA binding activity was increased in vascular smooth muscle cells (VSMC) from old rats when exposed to high glucose or tumor necrosis factor (TNF-α) (Li et al., 2003. J Cell Physiol 197:418–4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc629dca8ea2a327e1e2fb59d1df5b1
https://doi.org/10.1002/jcp.20496
https://doi.org/10.1002/jcp.20496
Autor:
Michael Jung, Sylke Buder-Hoffman, Brooke T. Mossman, Douglas J. Taatjes, Cynthia R. Timblin, Pamela M. Vacek, Steven M. Grunberg
Publikováno v:
Histochemistry and Cell Biology. 121:115-121
Concurrent administration of paclitaxel and vinorelbine results in cytotoxicity in vivo and in vitro in a number of tumor cell lines, yet the mechanisms of enhanced cell killing are undefined. In studies here, we show that low concentrations (1 nM) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5759ed2cc85d19c3890974a859f06a8
https://doi.org/10.1007/s00418-004-0618-8
https://doi.org/10.1007/s00418-004-0618-8
Autor:
Naomi K. Fukagawa, Muyao Li, Emily Kolpa, Douglas J. Taatjes, Cynthia R. Timblin, Brooke T. Mossman, Arti Shukla
Publikováno v:
Journal of Cellular Physiology. 197:418-425
Aortic vascular smooth muscle cells (VSMC) were used to study the effect of age on responses to high glucose concentrations or the cytokine, tumor necrosis factor-alpha (TNF-alpha). Activator protein-1 (AP-1) binding to DNA increased more in VSMC fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a999ccf36ce9edb86727c7f365b59236
https://doi.org/10.1002/jcp.10384
https://doi.org/10.1002/jcp.10384
Publikováno v:
Toxicology and Applied Pharmacology. 184:37-45
Alveolar type II epithelial cells are the main precursor cells that develop into carcinomas after inhalation of poorly soluble particles (PSP) at overload concentrations, but the mechanisms leading to initial proliferative events in these cells are u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38809cfc09151b045a2a09fee5e5c46c
https://doi.org/10.1006/taap.2002.9500
https://doi.org/10.1006/taap.2002.9500
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L968-L975
Occupational exposure to crystalline silica is associated with the development of pulmonary inflammation and silicosis, yet how silica initiates pulmonary fibrosis and which cell types are involved are unclear. In studies here, we hypothesized that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5696cca620fcca884edf1cb61231d6
https://doi.org/10.1152/ajplung.00327.2001
https://doi.org/10.1152/ajplung.00327.2001
Publikováno v:
Free Radical Biology and Medicine. 31:1560-1569
Old age is associated with a higher prevalence of cardiovascular disease and diabetes mellitus. Vascular smooth muscle cells (VSMC) play a role in the pathogenesis of vascular diseases, often a complication of diabetes mellitus. We examined in explan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3763a5dbdf5f99a4c3c6ff2c1d52fb
https://doi.org/10.1016/s0891-5849(01)00736-5
https://doi.org/10.1016/s0891-5849(01)00736-5
Autor:
Kevin E. Driscoll, Pamela M. Vacek, Brooke T. Mossman, Terry Gordon, Arti Shukla, Willie J. McKinney, Cynthia R. Timblin, Kelly Ann Berube
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 23:182-187
High levels of ambient air pollution are associated with exacerbation of asthma and respiratory morbidity, yet little is known concerning the mechanisms of inflammation and toxicity by components of inhaled particulate matter (PM). Brief inhalation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136aafa0cb83f57eedae5e796b3802bb
https://doi.org/10.1165/ajrcmb.23.2.4035
https://doi.org/10.1165/ajrcmb.23.2.4035
Publikováno v:
Inhalation Toxicology. 12:307-316
Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a92c22a6e2242681c4fa8d03fb7be1
https://doi.org/10.1080/08958378.2000.11463240
https://doi.org/10.1080/08958378.2000.11463240
Autor:
Pamela M. Vacek, Yvonne W. M. Janssen, Brooke T. Mossman, Cynthia R. Timblin, Eric S. Walsh, George D. Guthrie
Publikováno v:
Toxicology and Applied Pharmacology. 151:88-97
Erionite, a naturally occurring fibrous zeolite, is associated with the development of nonmalignant and malignant lung diseases and is more carcinogenic than asbestos fibers in man and rodent inhalation models of disease. To investigate the possible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee52bd370b4b6804e0d2f7dc006d1545
https://doi.org/10.1006/taap.1998.8450
https://doi.org/10.1006/taap.1998.8450