Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Cynthia Pape"'
Autor:
Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jahandideh, Kimberly F. Macala, Sareh Panahi, Cynthia Pape, David Sontag, Janet Sunohara-Neilson, Dean A. Fergusson, Alison E. Fox-Robichaud, Patricia C. Liaw, Manoj M. Lalu, Asher A. Mendelson, for the National Preclinical Sepsis Platform, Sepsis Canada
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platform
Externí odkaz:
https://doaj.org/article/2a7fa924fb5b4658b0da38387de75a6e
Autor:
Devika P. Jayawardena, Marcello G. Masciantonio, Lefeng Wang, Sanjay Mehta, Natalie DeGurse, Cynthia Pape, Sean E. Gill
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7875 (2023)
Sepsis is a life-threatening disease characterized by excessive inflammation leading to organ dysfunction. During sepsis, pulmonary microvascular endothelial cells (PMVEC) lose barrier function associated with inter-PMVEC junction disruption. Matrix
Externí odkaz:
https://doaj.org/article/ac0570e2218e4c2ba780483f3f7d6eb8
Autor:
Karel Tyml, Scott Swarbreck, Cynthia Pape, Dan Secor, James Koropatnick, Qingping Feng, Ruud A. W. Veldhuizen, Sean E. Gill
Publikováno v:
Critical Care, Vol 21, Iss 1, Pp 1-12 (2017)
Abstract Background Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic patients are elderly (60
Externí odkaz:
https://doaj.org/article/c5386ed2cde84f1ca490fd500ea6bffb
Autor:
Mistre Alemayehu, Magdalena Dragan, Cynthia Pape, Iram Siddiqui, David B Sacks, Gianni M Di Guglielmo, Andy V Babwah, Moshmi Bhattacharya
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56174 (2013)
β-Arrestins play critical roles in chemotaxis and cytoskeletal reorganization downstream of several receptor types, including G protein-coupled receptors (GPCRs), which are targets for greater than 50% of all pharmaceuticals. Among them, receptors f
Externí odkaz:
https://doaj.org/article/43275251b642493d8503c91127f50b41
Autor:
Mateusz Zajac, Jeffrey Law, Dragana Donna Cvetkovic, Macarena Pampillo, Lindsay McColl, Cynthia Pape, Gianni M Di Guglielmo, Lynne M Postovit, Andy V Babwah, Moshmi Bhattacharya
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21599 (2011)
Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, re
Externí odkaz:
https://doaj.org/article/5a69fdac4b1d42f0b509bfcdf2b09286
Autor:
Ruud Veldhuizen, Aminmohamed Manji, Alexandra Troitskaya, Lynda McCaig, Cynthia Pape, Sean Gill
Publikováno v:
Physiology. 38
Mechanical ventilation is a critical, life-saving therapy that can also negatively impact the lung by affecting edema formation, surfactant metabolism and function, and the release of inflammatory mediators. Outcomes in elderly patients requiring ven
Publikováno v:
Physiology. 38
Elderly individuals have substantially elevated morbidity and mortality during conditions of lung injury. However, the precise underlying mechanisms leading to this elevated mortality are ill-defined. Lung injury is associated with damage to pulmonar
Autor:
Moshmi Bhattacharya, Andy V. Babwah, Gordon B. Mills, Lynne-Marie Postovit, Macarena Pampillo, Cynthia Pape, Adel I. Aziziyeh, Mistre Alemayehu, Timothy T. Li
The lipid mediator lysophosphatidic acid (LPA) plays a role in cancer progression and signals via specific G protein–coupled receptors, LPA1-3. LPA has been shown to enhance the metastasis of breast carcinoma cells to bone. However, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0c2040ba283079c6e7c8239db7e82b
https://doi.org/10.1158/1541-7786.c.6542280.v1
https://doi.org/10.1158/1541-7786.c.6542280.v1
Autor:
Moshmi Bhattacharya, Andy V. Babwah, Gordon B. Mills, Lynne-Marie Postovit, Macarena Pampillo, Cynthia Pape, Adel I. Aziziyeh, Mistre Alemayehu, Timothy T. Li
Supplementary Data from β-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bac76af6bfb977ddfb7a7a65cda709a
https://doi.org/10.1158/1541-7786.22519074
https://doi.org/10.1158/1541-7786.22519074
Publikováno v:
BMJ Neurology Open, Vol 6, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/30374d4ebc6844ef8bec7c7c02e7b211