Výsledky vyhledávání - "Cynthia P. Quan"

Light-Induced Covalent Buffer Adducts to Histidine in a Model Protein

Autor: Christian Schöneich, Y. John Wang, Ming Lei, Cynthia P. Quan, Yung-Hsiang Kao

Publikováno v: Pharmaceutical Research. 35

Light is known to induce histidine (His) oxidation and His-His crosslinking in proteins. The crosslinking is resulted from the nucleophilic attack of a His to a photooxidized His from another protein. The goal of this work is to understand if covalen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afeaf5654a5e4b838625e88a0dbae8bb
https://doi.org/10.1007/s11095-017-2339-4

Zobrazit plný text záznamu

Structure-Based Correlation of Light-Induced Histidine Reactivity in A Model Protein

Autor: Camellia Zamiri, Nicholas Woon, Ming Lei, Taylor Yonghua Zhang, Yung-Hsiang Kao, Toshiro Carcelen, Cynthia P. Quan, Julie C. Nishihara, Christian Schöneich, Yuzhe Hu, Benjamin T. Walters, Holly Yip

Publikováno v: Analytical chemistry. 89(13)

Light is known to induce covalently linked aggregates in proteins. These aggregates can be immunogenic and are of concern for drug product development in the biotechnology industry. Histidine (His) is proposed to be a key residue in cross-link genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61b5b9347eeecaf2181ba7d620deaf8
https://pubmed.ncbi.nlm.nih.gov/28585810

Zobrazit plný text záznamu

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

Autor: Irena Petkovska, Domenic Matthews, Ron Taticek, Cynthia P. Quan, Emily W. Alcala, Stacey Ma, Eleanor Canova-Davis

Publikováno v: Analytical Biochemistry. 373:179-191

The glycated form of a basic recombinant humanized monoclonal antibody (rhuMAb) was separated and quantitated by boronate affinity chromatography using optimized shielding reagents. Characterization on the isolated glycated material by peptide mappin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45acc5856ee4b7c09e923d45af7c7b98
https://doi.org/10.1016/j.ab.2007.09.027

Zobrazit plný text záznamu

Structure−Function Analysis of a Phage Display-Derived Peptide That Binds to Insulin-like Growth Factor Binding Protein 1

Autor: David Y. Jackson, Kurt Deshayes, Henry B. Lowman, Nicholas J. Skelton, Yvonne Chen, M.T. Pisabarro, N. Dubree, Manuel Baca, Kerry Zobel, Andrea G. Cochran, Cynthia P. Quan

Publikováno v: Biochemistry. 40:8487-8498

Highly structured, peptide antagonists of the interaction between insulin-like growth factor 1 (IGF-I) and IGF binding protein 1 (IGFBP-1) have recently been discovered by phage display of naïve peptide libraries [Lowman, H. B., et al. (1998) Bioche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a29d1c335900f07b8d4b37d86de7cc2
https://doi.org/10.1021/bi0103866

Zobrazit plný text záznamu

Susceptibility of rhDNase I to Glycation in the Dry-Powder State

Autor: Cynthia P. Quan, Eleanor Canova-Davis, Chung Hsu, Tom Patapoff, Sylvia Sau-Yan Wu, Nancy Dasovich

Publikováno v: Analytical Chemistry. 71:4445-4454

The accumulated data on the glycation process in rhDNase I, formulated with lactose and stored in the dry-powder state, indicates that this protein becomes covalently modified with lactose at five of the six lysines (2, 50, 77, 157, 260) and to a les

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd6d065357d179a92342e0561fdd2c9
https://doi.org/10.1021/ac9900580

Zobrazit plný text záznamu

Use of acidic and basic pH and calcium ion addition in the capillary zone electrophoretic characterization of recombinant human deoxyribonuclease, a complex phosphoglycoprotein

Autor: Barry L. Karger, Eleanor Canova-Davis, Anthony Chen, Thomas M. McNerney, Chantal Felten, Wolfgang Goetzinger, Cynthia P. Quan

Publikováno v: Journal of Chromatography A. 853:295-308

This paper describes the analysis of recombinant human deoxyribonuclease (rhDNAse), an acidic and complex phosphoglycoprotein, by capillary zone electrophoresis (CZE). Separation performance was found to be dramatically improved by the addition of ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14aa9990855fac60619dc21f2e6c626
https://doi.org/10.1016/s0021-9673(99)00678-0

Zobrazit plný text záznamu

Transfer of a protein binding epitope to a minimal designed peptide

Autor: David Y. Jackson, H H Chiu, Susan M. Keating, Nicholas J. Skelton, M. E. Renz, Dean R. Artis, Cynthia P. Quan, Kevin R Clark, Maureen Beresini, Sherman Fong

Publikováno v: Biopolymers. 47:265-275

Results from protein mutagenesis and x-ray crystallographic studies of the multidomain protein Vascular Cell Adhesion Molecule (VCAM) were used to design cyclic octapeptides that retain the critical structural and binding elements of the epitope of V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72bb39ff6551186481948439be4fe3b9
https://doi.org/10.1002/(sici)1097-0282(1998)47:4<265::aid-bip2>3.0.co

Zobrazit plný text záznamu

Protein sorting by high-performance liquid chromatography

Autor: M.B. Sliwkowski, Cynthia P. Quan, Jerry Cacia, John Frenz, M. Vasser

Publikováno v: Journal of Chromatography A. 634:229-239

Chromatographic separations can be tailored to exploit specific interactions between a stationary phase ligand and a protein structural feature of interest. Variations in this feature then form the basis for sorting a mixture of closely related prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc3fd96ccdcf31a650e8d07c6b3f61b4
https://doi.org/10.1016/0021-9673(93)83009-h

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání