Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Cynthia Nourigat-McKay"'
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Autor:
Tessa Dignum, Barbara Varnum-Finney, Sanjay R. Srivatsan, Stacey Dozono, Olivia Waltner, Adam M. Heck, Takashi Ishida, Cynthia Nourigat-McKay, Dana L. Jackson, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109675- (2021)
Summary: During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). Although previous studies have shown that yolk-sac-derived erythromyelo
Externí odkaz:
https://doaj.org/article/aeadf5874656435cb00af40d81bd981a
Autor:
Takashi Ishida, Adam M Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-Mckay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana L Jackson, Cole Trapnell, Shahin Rafii, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Blood. 140:8574-8575
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14271786781ee1c6cd2bd5c03764d06
https://doi.org/10.1182/blood-2022-156513
https://doi.org/10.1182/blood-2022-156513
Autor:
Takashi Ishida, Adam Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-McKay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana Jackson, Colleen Delaney, Cole Trapnell, Shahin Rafii, Irwin Bernstein, Brandon Hadland
Publikováno v:
Experimental Hematology. 111:S96-S97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65203c7cdb34f07f40a38d1e365de5c7
https://doi.org/10.1016/j.exphem.2022.07.160
https://doi.org/10.1016/j.exphem.2022.07.160
Autor:
Quy Le, Feng Chen, Thao Tang, Cynthia Nourigat McKay, Fei Wu, Melik Turker, Thomas Gardinier, Vaibhav Patel, Aranapakam Venkatesan, Tin Khor, Kai Ma, Gregory P. Adams, Soheil Meshinchi
Publikováno v:
Cancer Research. 82:1075-1075
Acute myeloid leukemia (AML) in infants is a unique subtype of AML that is driven by oncogenic fusions, resulting in a highly proliferative disease. The CBFA2T3-GLIS2 oncogenic fusion that is seen exclusively in infants and young children Citation Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c61b43a3e8d5c39fe5cbc1b4ecfec6df
https://doi.org/10.1158/1538-7445.am2022-1075
https://doi.org/10.1158/1538-7445.am2022-1075
Autor:
Sanjay Srivatsan, Barbara Varnum-Finney, Cynthia Nourigat-Mckay, Dana Jackson, Brandon Hadland, Shahin Rafii, Cole Trapnell, Adam M Heck, Tessa Dignum, Olivia Waltner, Irwin D. Bernstein, Stacey Dozono
SUMMARYDuring embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). Although previous studies have shown that yolk sac-derived erythromyeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a84988cc0099f0305022ac79db16f9f
https://doi.org/10.1101/2021.04.13.439736
https://doi.org/10.1101/2021.04.13.439736
Autor:
Barbara Varnum-Finney, Cynthia Nourigat-Mckay, Itkin T, Irwin D. Bernstein, Shahin Rafii, Jason M. Butler, Brandon Hadland, Cole Trapnell, Stacey Dozono, Tessa Dignum, Dana Jackson
Haematopoietic stem cells (HSCs) develop from haemogenic endothelium (HE) within embryonic arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify the signals responsible for HSC formation, we used single cell RNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0aaf5cbe8278d008a5b99cc6cc4a89
https://doi.org/10.1101/2021.01.25.427999
https://doi.org/10.1101/2021.01.25.427999
Autor:
Shahin Rafii, Stacey Dozono, Brandon Hadland, Cole Trapnell, Barbara Varnum-Finney, Irwin D. Bernstein, Adam M Heck, Olivia Waltner, Dana Jackson, Sanjay Srivastan, Cynthia Nourigat-Mckay, Tessa Dignum
Publikováno v:
SSRN Electronic Journal.
During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). Although previous studies have shown that yolk sac-derived erythromyeloid progeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a983a6cd501aefb1318701a1307a58
https://doi.org/10.2139/ssrn.3832990
https://doi.org/10.2139/ssrn.3832990
Autor:
Quy Le, LaKeisha Perkins, Laura Pardo, Cynthia Nourigat-Mckay, Soheil Meshinchi, Amanda R. Leonti, Lindsey F Call, Thao T. Tang, Sommer Castro
Publikováno v:
Blood. 138:1712-1712
Effective immunotherapy for acute myeloid leukemia (AML) has been limited by the lack of AML-restricted targets (expression in AML but silent in normal hematopoiesis). Current immunotherapies targeting lineage markers CD33 and CD123 (if effective) wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5c35230b18e9d1441900e0508e5c9c
https://doi.org/10.1182/blood-2021-153156
https://doi.org/10.1182/blood-2021-153156
Autor:
Amanda R. Leonti, Cynthia Nourigat-Mckay, Rhonda E. Ries, Tiffany A. Hylkema, Sommer Castro, Michael R. Loken, LaKeisha Perkins, Thao T. Tang, Soheil Meshinchi, Lisa Eidenschink Brodersen, Jenny L. Smith, Laura Pardo, Keith R. Loeb, Quy Le
Publikováno v:
Blood. 138:360-360
The CBFA2T3-GLIS2 (CBF/GLIS) fusion is a product of a cryptic translocation exclusively seen in refractory infant AML. Lack of relevant model systems that accurately recapitulate this infant AML has limited progress. To overcome this barrier, we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27955f1e6f8db810fa370ca1aadd387c
https://doi.org/10.1182/blood-2021-148916
https://doi.org/10.1182/blood-2021-148916