Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Cynthia Nourigat"'
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Autor:
Tessa Dignum, Barbara Varnum-Finney, Sanjay R. Srivatsan, Stacey Dozono, Olivia Waltner, Adam M. Heck, Takashi Ishida, Cynthia Nourigat-McKay, Dana L. Jackson, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109675- (2021)
Summary: During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). Although previous studies have shown that yolk-sac-derived erythromyelo
Externí odkaz:
https://doaj.org/article/aeadf5874656435cb00af40d81bd981a
Autor:
Christopher T. Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A. Flowers, Olivier Negre, Olivier Humbert, Julia G. Yang, Calvin Lee, Kyle Jacoby, Irwin Bernstein, Hans-Peter Kiem, Andrew Scharenberg, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 175-183 (2019)
Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clini
Externí odkaz:
https://doaj.org/article/d1669924b97e44a4beafad9d2ebc6f23
Autor:
Takashi Ishida, Adam M Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-Mckay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana L Jackson, Cole Trapnell, Shahin Rafii, Irwin D. Bernstein, Brandon Hadland
Publikováno v:
Blood. 140:8574-8575
Autor:
Jay F. Sarthy, Suzan Imren, Brandon Hadland, Soheil Meshinchi, Sommer Castro, Keith R. Loeb, Benjamin J. Huang, Cynthia Nourigat, Scott N. Furlan, LaKeisha Perkins, Shivani Srivastava, Rhonda E. Ries, Thao T Tang, Irwin D. Bernstein, Jenny L. Smith, Lisa Eidenschink Brodersen, Katherine Tarlock, Stanley R. Riddell, Larua Pardo, Lindsey F Call, Amy Beckman, Rhonda Idemmili, Amanda R. Leonti, Tiffany A. Hylkema, Takashi Ishida, Anisha M Loeb, Quy Le, Loken Michael, Robin Williams
Fusion oncoproteins are the initiating event in AML pathogenesis, although they are thought to require additional cooperating mutations for leukemic transformation. CBFA2T3-GLIS2 (C/G) fusion occurs exclusively in infants and is associated with highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006f550daf8c2558a104753f1a38f789
https://doi.org/10.21203/rs.3.rs-757279/v1
https://doi.org/10.21203/rs.3.rs-757279/v1
Autor:
Takashi Ishida, Adam Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-McKay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana Jackson, Colleen Delaney, Cole Trapnell, Shahin Rafii, Irwin Bernstein, Brandon Hadland
Publikováno v:
Experimental Hematology. 111:S96-S97
Autor:
Fang Sun, Suzan Imren, Bowen Li, Fabiola Merriam, Cynthia Nourigat, Shelly Heimfeld, Peng Zhang, Priyesh Jain, Andrew Sinclair, Jianqiang Li, Colleen Delaney, Ryan Basom, Tao Bai, Hsiang-Chieh Hung, Jeffrey J. Delrow, Mary Beth O'Kelly, Shaoyi Jiang
Publikováno v:
Nature Medicine. 25:1566-1575
The ability to expand hematopoietic stem and progenitor cells (HSPCs) ex vivo is critical to fully realize the potential of HSPC-based therapies. In particular, the application of clinically effective therapies, such as cord blood transplantation, ha
Autor:
Irwin D. Bernstein, Julia G. Yang, Andrew M. Scharenberg, Christopher T. Lux, Olivier Negre, Sowmya Pattabhi, David A. Flowers, Kyle Jacoby, Mason P. Berger, Hans-Peter Kiem, Calvin Lee, Cynthia Nourigat, Olivier Humbert, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss, Pp 175-183 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clini
Autor:
Quy Le, Feng Chen, Thao Tang, Cynthia Nourigat McKay, Fei Wu, Melik Turker, Thomas Gardinier, Vaibhav Patel, Aranapakam Venkatesan, Tin Khor, Kai Ma, Gregory P. Adams, Soheil Meshinchi
Publikováno v:
Cancer Research. 82:1075-1075
Acute myeloid leukemia (AML) in infants is a unique subtype of AML that is driven by oncogenic fusions, resulting in a highly proliferative disease. The CBFA2T3-GLIS2 oncogenic fusion that is seen exclusively in infants and young children Citation Fo
Autor:
Sanjay Srivatsan, Barbara Varnum-Finney, Cynthia Nourigat-Mckay, Dana Jackson, Brandon Hadland, Shahin Rafii, Cole Trapnell, Adam M Heck, Tessa Dignum, Olivia Waltner, Irwin D. Bernstein, Stacey Dozono
SUMMARYDuring embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). Although previous studies have shown that yolk sac-derived erythromyeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a84988cc0099f0305022ac79db16f9f
https://doi.org/10.1101/2021.04.13.439736
https://doi.org/10.1101/2021.04.13.439736