Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cynthia Metierre"'
Autor:
Bijay P. Dhungel, Geoffray Monteuuis, Caroline Giardina, Mehdi S. Tabar, Yue Feng, Cynthia Metierre, Sarah Ho, Rajini Nagarajah, Angela R. M. Fontaine, Jaynish S. Shah, Divya Gokal, Charles G. Bailey, Ulf Schmitz, John E. J. Rasko
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12178 (2021)
Chimeric RNAs are often associated with chromosomal rearrangements in cancer. In addition, they are also widely detected in normal tissues, contributing to transcriptomic complexity. Despite their prevalence, little is known about the characteristics
Externí odkaz:
https://doaj.org/article/76580557ad97406c8cd6513f7e7d7f09
Autor:
Fiona H. X. Guan, Charles G. Bailey, Cynthia Metierre, Patrick O’Young, Dadi Gao, Teh Liane Khoo, Jeff Holst, John E. J. Rasko
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)
Abstract Background ELF2 (E74-like factor 2) also known as NERF (new Ets-related factor), a member of the Ets family of transcription factors, regulates genes important in B and T cell development, cell cycle progression, and angiogenesis. Conserved
Externí odkaz:
https://doaj.org/article/7b2473cba9a04a6ba0866c14b53fc6ad
Autor:
Charles G Bailey, Cynthia Metierre, Yue Feng, Kinsha Baidya, Galina N Filippova, Dmitri I Loukinov, Victor V Lobanenkov, Crystal Semaan, John EJ Rasko
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3832 (2018)
CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. Cancer genome sequencing reveals diverse acquired mutations in CTCF, which we have shown functions a
Externí odkaz:
https://doaj.org/article/af107fc83d5b4ff9925d9cfedc938201
Autor:
Mehdi Sharifi Tabar, Wunna Kyaw, Krishna P. Singh, Charles G. Bailey, Shailendra K. Gupta, Tatyana Laletin, Olaf Wolkenhauer, Punkaja M S Amarasekera, Charles G. Mullighan, Cynthia Metierre, Habib Francis, Ulf Schmitz, John E.J. Rasko, Crystal Semaan, Patrick O’Young
Publikováno v:
Cellular and Molecular Life Sciences
CCCTC-binding factor (CTCF) plays fundamental roles in transcriptional regulation and chromatin architecture maintenance. CTCF is also a tumour suppressor frequently mutated in cancer, however, the structural and functional impact of mutations have n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91f286de1cb5f8f085fccec24662483
https://doi.org/10.1007/s00018-021-03946-z
https://doi.org/10.1007/s00018-021-03946-z
CTCF zinc finger mutations produce cellular phenotypes explained by structure-function relationships
Autor:
Patrick O’Young, Tatyana Laletin, Ulf Schmitz, Olaf Wolkenhauer, Wunna Kyaw, Charles G. Mullighan, Habib Francis, John E.J. Rasko, Cynthia Metierre, Crystal Semaan, Punkaja Amarasekara, Charles G. Bailey, Krishna P. Singh, Shailendra K. Gupta
CCCTC-binding factor (CTCF) plays fundamental roles in transcriptional regulation and chromatin architecture maintenance. CTCF is also a tumour suppressor frequently mutated in cancer, however the structural and functional impact of mutations have no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::349026969a8287ce87e36abf81cb282d
https://doi.org/10.21203/rs.3.rs-232459/v1
https://doi.org/10.21203/rs.3.rs-232459/v1
Autor:
Tatyana Laletin, Krishna P. Singh, Charles G. Bailey, Shailendra K. Gupta, Olaf Wolkenhauer, John E.J. Rasko, Wunna Kyaw, Punkaja M S Amarasekera, Crystal Semaan, Ulf Schmitz, Cynthia Metierre, Charles G. Mullighan, Patrick O’Young, Habib Francis
BackgroundHuman cancers commonly contain mutations in transcription factors that lead to aberrant DNA binding or altered effector function at target sites. One such factor significantly mutated in cancer is the evolutionarily-conserved CCCTC-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbfecbea7f9cc5b7a9404883ab708ee
https://doi.org/10.1101/2021.01.08.425848
https://doi.org/10.1101/2021.01.08.425848
Autor:
Susan J. Clark, Phuc-Loi Luu, Timothy P. Hughes, Shalima S. Nair, Veronika Petrova, Charles G. Bailey, Deborah L. White, Susan Branford, Ulf Schmitz, John E.J. Rasko, Verity A Saunders, Justin J.-L. Wong, Geoffray Monteuuis, Jaynish S. Shah, Bijay Dhungel, Cynthia Metierre, Ali G. Turhan
Publikováno v:
Cancers
Volume 12
Issue 12
Cancers, Vol 12, Iss 3738, p 3738 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3738, p 3738 (2020)
Simple Summary This study provides new insights into the changing transcriptomic and epigenomic landscapes in chronic myeloid leukaemia (CML) patients who are receiving tyrosine kinase inhibitor (TKI) therapy (often life-long). Alternative splicing,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fb6b4945e8e7438959ee89e1816e00
https://doi.org/10.1101/2020.07.31.20165597
https://doi.org/10.1101/2020.07.31.20165597
Autor:
John E.J. Rasko, Crystal Semaan, Galina N. Filippova, Kinsha Baidya, Cynthia Metierre, Yue Feng, Dmitri Loukinov, Victor V. Lobanenkov, Charles G. Bailey
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3832 (2018)
International Journal of Molecular Sciences
Volume 19
Issue 12
International Journal of Molecular Sciences
Volume 19
Issue 12
CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. Cancer genome sequencing reveals diverse acquired mutations in CTCF, which we have shown functions a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd450d87449ed6213d45a2af8d7ee55e
https://www.mdpi.com/1422-0067/19/12/3832
https://www.mdpi.com/1422-0067/19/12/3832
Autor:
Michelle van Geldermalsen, Charles G. Bailey, Andrew J. Hoy, Natalia Pinello, John E.J. Rasko, Martin E. Gleave, Nicholas J. Otte, Colleen C. Nelson, Martin C. Sadowski, Rae-Anne Hardie, Qian Wang, Dadi Gao, Seher Balaban, Justin J.-L. Wong, Mark Schreuder, Ladan Fazli, William Ritchie, Cynthia Metierre, Rajini Nagarajah, Melanie Lehman, Jeff Holst
Publikováno v:
The Journal of Pathology
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the tricarboxylic acid (TCA) cycle. In this study, we demonstrated that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98149121d0703c25df6280299eebad8e
https://doi.org/10.1002/path.4518
https://doi.org/10.1002/path.4518
Autor:
Patrick O’Young, Fiona H. X. Guan, Jeff Holst, Dadi Gao, John E.J. Rasko, Charles G. Bailey, Cynthia Metierre, Teh Liane Khoo
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)
Background ELF2 (E74-like factor 2) also known as NERF (new Ets-related factor), a member of the Ets family of transcription factors, regulates genes important in B and T cell development, cell cycle progression, and angiogenesis. Conserved ELF2 isof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbdff47c824462791904bff70f2f41c
https://pubmed.ncbi.nlm.nih.gov/28351373
https://pubmed.ncbi.nlm.nih.gov/28351373