Výsledky vyhledávání - "Cynthia M. Rusk"

Immunogenicity of conjugate vaccines consisting of pneumococcal capsular polysaccharide types 6B, 14, 19F, and 23F and a meningococcal outer membrane protein complex

Autor: Arpi Hagopian, Joan M. Staub, Charlotte C. Yu Ip, Peter J. Kniskern, Cynthia M. Rusk, Stephen Marburg, P. P. Vella, L. S. Chupak, William J. Miller, R. L. Tolman

Publikováno v: Infection and Immunity. 60:4977-4983

In an effort to prepare pneumococcal (Pn) capsular polysaccharide (Ps) vaccines that would be immunogenic in infants, covalent conjugates were prepared for Pn types 6B, 14, 19F, and 23F. Each Ps type was covalently bound to an outer membrane protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b200496e72c3747e417649ef2d22b42
https://doi.org/10.1128/iai.60.12.4977-4983.1992

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Immunogenicity of a New Haemophilus influenzae Type b Conjugate Vaccine (Meningococcal Protein Conjugate) (PedvaxHIBTM)

Autor: Philip P. Vella, Joan M. Staub, Jack Armstrong, Kathleen T. Dolan, Cynthia M. Rusk, Sally Szymanski, William E. Greer, Stephen Marburg, Peter J. Kniskern, Timothy L. Schofield, Richard L. Tolman, Fredrick Hartner, Shih-hsie Pan, Robert J. Gerety, Ronald W. Ellis

Publikováno v: Pediatrics. 85:668-675

Haemophilus influenzae type b is responsible for an estimated 15 000 to 20 000 cases of meningitis per year in the United States, mainly in children 2 months to 5 years old.1-4 The mortality rate from meningitis due to H influenzae type b infections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c987d450978e72cad63ccaff4f1eb0c
https://doi.org/10.1542/peds.85.4.668

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Haemophilus influenzae Type b Conjugate Vaccine (Meningococcal Protein Conjugate) (PedvaxHIBTM): Clinical Evaluation

Autor: Vincent I. Ahonkhai, Linda J. Lukacs, Leslie C. Jonas, Holly Matthews, Philip P. Vella, Ronald W. Ellis, Joan M. Staub, Kathleen T. Dolan, Cynthia M. Rusk, Gary B. Calandra, Robert J. Gerety

Publikováno v: Pediatrics. 85:676-681

Although systemic infections caused by Haemophilus influenzae type b occur worldwide, detailed epidemiologic data are available in but a few countries.1-3 The public health impact of morbidity, mortality, and serious sequelae from disease caused by H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3df765b343b64353191b47f9ac8e942
https://doi.org/10.1542/peds.85.4.676

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Antibody Responses to Capsular Polysaccharide Backbone and O-Acetate Side Groups of Streptococcus pneumoniae Type 9V in Humans and Rhesus Macaques

Autor: Joan M. Staub, Michael J. Blum, Cynthia M. Rusk, John J. Donnelly, Tessie McNeely

Streptococcus pneumoniae is responsible for high rates of pneumococcal bacteremia, meningitis, pneumonia, and acute otitis media worldwide. Protection from disease is conferred by antibodies specific for the polysaccharide (Ps) capsule of the bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015e64b22a5feb71506b5f9f973da06b
https://europepmc.org/articles/PMC108405/

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Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells

Autor: Warren J. Leonard, Cynthia M. Rusk, Penny B. Svetlik, Richard J. Robb, Warner C. Greene, Joel M. Depper

Publikováno v: The Journal of Experimental Medicine

Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836f6a9a8c43df7f86048140c496cd9f
https://doi.org/10.1084/jem.162.1.363

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Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors

Autor: Richard J. Robb, Cynthia M. Rusk, Junji Yodoi, Warner C. Greene

Publikováno v: Proceedings of the National Academy of Sciences. 84:2002-2006

Interleukin 2 (IL-2) receptors on activated T cells exist in high- and low-affinity configurations, both of which share a ligand-binding component known as the Tac protein. Although almost all binding of IL-2 to such cells was inhibited by an antibod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c714df62ed456ac773b00108f638c28b
https://doi.org/10.1073/pnas.84.7.2002

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Structure-function relationships for the interleukin 2 receptor: location of ligand and antibody binding sites on the Tac receptor chain by mutational analysis

Autor: Michael P. Neeper, Richard J. Robb, Cynthia M. Rusk

Publikováno v: Proceedings of the National Academy of Sciences. 85:5654-5658

The Tac protein plays a role in high- and low-affinity interleukin 2 (IL-2) receptors. A mutational survey of this molecule identified several small segments in which the binding of IL-2 was particularly sensitive to amino acid substitutions. Two of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f49ed818d33cc5cb5314ba018a1b9cd
https://doi.org/10.1073/pnas.85.15.5654

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Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen

Autor: Richard J. Robb, Warner C. Greene, Cynthia M. Rusk

Publikováno v: The Journal of experimental medicine, vol 160, iss 4
The Journal of Experimental Medicine

Interleukin 2 promotes proliferation of T cells by virtue of its interaction with a high-affinity cell surface receptor. This receptor is a 55,000 mol wt glycoprotein that is also recognized by the murine monoclonal antibody, anti-Tac. Quantitative b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6aa8ad753c6852c39f878c7b76e4465
https://escholarship.org/uc/item/30x9j9zc

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