Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cynthia M. June"'
Autor:
Joshua M. Mitchell, Cynthia M. June, Vincent L. Baggett, Beth C. Lowe, James F. Ruble, Robert A. Bonomo, David A. Leonard, Rachel A. Powers
Publikováno v:
Journal of Biological Chemistry. 298:102127
The evolution of multidrug resistance in Acinetobacter spp. increases the risk of our best antibiotics losing their efficacy. From a clinical perspective, the carbapenem-hydrolyzing class D β-lactamase subfamily present in Acinetobacter spp. is part
Autor:
Rachel A. Powers, David A. Leonard, Robert A. Bonomo, Thomas M. Harper, Cynthia M. June, Magdalena A. Taracila
Publikováno v:
Biochemical Journal. 475:273-288
OXA-239 is a class D carbapenemase isolated from an Acinetobacter baumannii strain found in Mexico. This enzyme is a variant of OXA-23 with three amino acid substitutions in or near the active site. These substitutions cause OXA-239 to hydrolyze late
Autor:
David A. Leonard, Agnieszka Szarecka, Rachel A. Powers, Kip Chumba J. Kaitany, Neil V. Klinger, Jozlyn R. Clasman, James R. LaFleur, Robert A. Bonomo, Joshua M. Mitchell, Troy Wymore, Cynthia M. June, Magdalena A. Taracila
Publikováno v:
Biochemistry. 54:1976-1987
The carbapenem-hydrolyzing class D β-lactamases OXA-23 and OXA-24/40 have emerged worldwide as causative agents for β-lactam antibiotic resistance in Acinetobacter species. Many variants of these enzymes have appeared clinically, including OXA-160
Autor:
Robert A. Bonomo, Laurie A. Witucki, Lucas S. Ulberg, David A. Leonard, Robert M. Vaughan, Cynthia M. June
Publikováno v:
Analytical Biochemistry. 463:70-74
By reacting fluorescein isothiocyanate with meropenem, we have prepared a carbapenem-based fluorescent β-lactam. Fluorescein-meropenem binds both penicillin-binding proteins and β-lactam sensors and undergoes a typical acylation reaction in the act
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:333-341
Since the discovery and use of penicillin, the increase of antibiotic resistance among bacterial pathogens has become a major health concern. The most prevalent resistance mechanism in Gram-negative bacteria is due to β-lactamase expression. Class D
Autor:
David A. Leonard, Agnieszka Szarecka, Rachel A. Powers, Taylor J. Muckenthaler, Zdzislaw Wawrzak, Cynthia M. June, Emma C. Schroder, Zachary L. Klamer
Publikováno v:
Protein science : a publication of the Protein Society. 25(12)
OXA-51 is a class D β-lactamase that is thought to be the native carbapenemase of Acinetobacter baumannii. Many variants of OXA-51 containing active site substitutions have been identified from A. baumannii isolates, and some of these substitutions
Autor:
David A. Leonard, Ayşegül Çopur Çiçek, Azer Özad Düzgün, Ayşegül Saral, Cynthia M. June, Cemal Sandalli
DUZGUN, AZER OZAD/0000-0002-6301-611X; DUZGUN, AZER OZAD/0000-0002-6301-611X; SANDALLI, Cemal/0000-0002-1298-3687; SARAL, AYSEGUL/0000-0002-7757-6812 WOS: 000390615900003 PubMed: 27168312 The class A p-lactamase GES-22 has been identified in Acinetob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e106743cad059269e2d28e60b3e57e
https://hdl.handle.net/11494/2041
https://hdl.handle.net/11494/2041
Autor:
Cynthia M. June, Ayşegül Saral, David A. Leonard, Zachary L. Klamer, Troy Wymore, Emma C. Schroder, Kyle A. Sugg, Agnieszka Szarecka
The threat posed by the chromosomally encoded class D β-lactamase of Acinetobacter baumannii (OXA-51/66) has been unclear, in part because of its relatively low affinity and turnover rate for carbapenems. Several hundred clinical variants of OXA-51/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b659c575ca86f1831841fa2d3885cc7
https://hdl.handle.net/11494/2079
https://hdl.handle.net/11494/2079
Autor:
David A. Leonard, Rachel A. Powers, Maddison E. Ramey, Kip Chumba J. Kaitany, Robert A. Bonomo, Neil V. Klinger, Cynthia M. June
Class D β-lactamases that hydrolyze carbapenems such as imipenem and doripenem are a recognized danger to the efficacy of these “last-resort” β-lactam antibiotics. Like all known class D carbapenemases, OXA-23 cannot hydrolyze the expanded-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089fc036b238b03cc94d49925ade2eca
https://europepmc.org/articles/PMC3811470/
https://europepmc.org/articles/PMC3811470/
Autor:
Ian Mcbain, Cynthia M. June, Mykhailo Videiko, Catherine M. Willis, Alexey G. Nikitin, Igor T. Kochkin
Publikováno v:
Human biology. 81(1)
Genetic studies of the distribution of mitochondrial DNA (mtDNA) haplogroups in human populations residing within the Carpathian Mountain range have been scarce. We present an analysis of mtDNA haplogroup composition of the Boykos, Hutsuls, and Lemko