Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Cynthia M. Chio"'
Autor:
James E. Longbotham, Cynthia M. Chio, Venkatasubramanian Dharmarajan, Michael J. Trnka, Idelisse Ortiz Torres, Devrishi Goswami, Karen Ruiz, Alma L. Burlingame, Patrick R. Griffin, Danica Galonić Fujimori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The demethylase activity of KDM5A is allosterically enhanced by binding of histone H3 to its PHD1 reader domain, through an unknown mechanism. Here the authors show that the PHD1 domain drives ligand-induced allosteric stimulation by stabilizing the
Externí odkaz:
https://doaj.org/article/8af366d414d64557aaf7cda67d5a31e7
Autor:
David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://doaj.org/article/120375a9425d4b15800ba82e59af4543
Autor:
Patrick R. Griffin, Alma L. Burlingame, Karen Ruiz, James E. Longbotham, Michael J. Trnka, Venkatasubramanian Dharmarajan, Danica Galonić Fujimori, Devrishi Goswami, Cynthia M. Chio, Idelisse Ortiz Torres
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Histone demethylase KDM5A removes methyl marks from lysine 4 of histone H3 and is often overexpressed in cancer. The in vitro demethylase activity of KDM5A is allosterically enhanced by binding of its product, unmodified H3 peptides, to its PHD1 read
Autor:
Un Seng Chio, Ming Sun, Adolfo García-Sastre, R.A. Saunders, Niv Dobzinski, Jiahao Liang, Vladislav Belyy, Peter Walter, Caleigh M. Azumaya, Beth S. Zha, Fei Li, Morgane Boone, Kris M. White, Yuwei Liu, Kaitlin Schaefer, Frank R. Moss, Aashish Manglik, Nevan J. Krogan, Michael C. Thompson, Nick Hoppe, Alexandrea N. Rizo, Axel F. Brilot, Danielle L. Swaney, S. Dickinson, Corie Y. Ralston, Bryan Faust, Devan Diwanji, A.W. Barile-Hill, Camille R. Simoneau, Smriti Sangwan, Sayan Gupta, Benjamin Barsi-Rhyne, Mingliang Jin, Veronica V. Rezelj, Huong T. Kratochvil, Silke Nock, David Bulkley, Kristoffer E. Leon, Marco Vignuzzi, Sergei Pourmal, Henry C. Nguyen, Thomas H. Pospiech, Gregory E. Merz, Raphael Trenker, Cynthia M. Chio, Yanxin Liu, Kaihua Zhang, Meghna Gupta, Aditya A. Anand, Cristina Puchades, M. Zimanyi, Amber M. Smith, Michael Schoof, Christian B. Billesbølle, Melanie Ott, Ishan Deshpande
Publikováno v:
Science (New York, N.y.)
Science
Science
Nanobodies that neutralize Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intravenously. B
Autor:
Henry C. Nguyen, Devan Diwanji, Smriti Sangwan, Sayan Gupta, Niv Dobzinski, Michael C. Thompson, M. Zimanyi, Rezelj, Marco Vignuzzi, Camille R. Simoneau, Corie Y. Ralston, Cristina Puchades, Thomas H. Pospiech, Beth S. Zha, Kaihua Zhang, Jiahao Liang, Sergei Pourmal, Axel F. Brilot, David Bulkley, Fei Li, Danielle L. Swaney, Nick Hoppe, A.W. Barile-Hill, Amber M. Smith, Raphael Trenker, Melanie Ott, Un Seng Chio, Gregory E. Merz, Ishan Deshpande, Alexandrea N. Rizo, Peter Walter, Kris M. White, R.A. Saunders, Ming Sun, Aditya A. Anand, Morgane Boone, Adolfo García-Sastre, Cynthia M. Chio, Yanxin Liu, Kaitlin Schaefer, Aashish Manglik, Nevan J. Krogan, Frank R. Moss, S. Dickinson, Huong T. Kratochvil, Caleigh M. Azumaya, Silke Nock, Mingliang Jin, Kristoffer E. Leon, Belyy, Meghna Gupta, Michael Schoof, Christian B. Billesbølle, Bryan Faust, Benjamin Barsi-Rhyne
Publikováno v:
bioRxiv
Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host cells via an interaction between its Spike protein and the host cell recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f1f208dd04d4d89775155b81ed47fe
https://doi.org/10.1101/2020.08.08.238469
https://doi.org/10.1101/2020.08.08.238469
Autor:
Danielle L. Swaney, Alexander M. Wolff, Tamas L. Nagy, Douglas Myers-Turnbull, Douglas R. Wassarman, Kyle A. Barlow, Paul V. Thomas, Rachel M. Brunetti, Derek Britain, Kevin Lou, Sy Redding, Wesley M. Marin, Mary K. Tsai, Kurt S. Thorn, Ryan W. Tibble, Lillian R. Kenner, Daniel M. C. Schwarz, Charlotte A. Nelson, Bruk Mensa, Fatima S. Ugur, Derek Bogdanoff, Taia S. Wu, E. Kang, Nicholas J. Rettko, Leanna S. Morinishi, Peter F. McTigue, Martin Kampmann, Gabriel K. Reder, Eric D. Chow, Alison M Maxwell, Jason Town, James S. Fraser, Andrew M. Natale, David P. Bauer, Cole Helsell, Joseph L. DeRisi, Yuliya Birman, Pooja Suresh, Evan M. Green, Ruilin Tian, Jennifer Y. Li, Sergei Pourmal, Weilin Chen, Hiten D. Madhani, Daniel N. Bolon, Miles Sasha Dickinson, Shane O’Conchúir, Keely Oltion, Daniel Asarnow, Peter J. Rohweder, Susanna K. Elledge, David Mavor, Erin M. Poss, Matvei S. Khoroshkin, Beatrice Ary, Ian D. Bergman, Nadja Kern, Taylor Arhar, Lisa L. Kirkemo, Tanja Kortemme, Sophia K. Tan, Shizhong Dai, Greyson R. Lewis, Nathan L. Hendel, Cynthia M. Chio
Publikováno v:
Biology Open
Biology open, vol 7, iss 7
Biology Open, Vol 7, Iss 7 (2018)
Mavor, D; Barlow, KA; Asarnow, D; Birman, Y; Britain, D; Chen, W; et al.(2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. BIOLOGY OPEN, 7(7). doi: 10.1242/bio.036103. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2hz894gr
Biology open, vol 7, iss 7
Biology Open, Vol 7, Iss 7 (2018)
Mavor, D; Barlow, KA; Asarnow, D; Birman, Y; Britain, D; Chen, W; et al.(2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. BIOLOGY OPEN, 7(7). doi: 10.1242/bio.036103. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2hz894gr
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:2828-2838
Protein tyrosine phosphatases (PTPs), which catalyze the dephosphorylation of phosphotyrosine in protein substrates, are critical regulators of metazoan cell signaling and have emerged as potential drug targets for a range of human diseases. Strategi
Publikováno v:
Biochemistry
Protein tyrosine phosphatases (PTPs) have been the subject of considerable pharmaceutical-design efforts because of the ubiquitous connections between misregulation of PTP activity and human disease. PTP-inhibitor discovery has been hampered, however
Autor:
Nadja Kern, Taylor Arhar, Matvei S. Khoroshkin, Ian D. Bergman, Lisa L. Kirkemo, Danielle L. Swaney, Nathan L. Hendel, Jason Town, Weilin Chen, Lillian R. Kenner, Alexander M. Wolff, Wesley M. Marin, Rachel M. Brunetti, Charlotte A. Nelson, Susanna K. Elledge, Sergei Pourmal, Greyson R. Lewis, Cynthia M. Chio, Derek Britain, Derrick Bogdanoff, Andrew M. Natale, Shane O’Conchúir, Martin Kampmann, Douglas R. Wassarmann, Kyle A. Barlow, Bruk Mensa, Gabriel K. Reder, Kurt S. Thorn, Ryan W. Tibble, Pooja Suresh, Sy Redding, Keely Oltion, Tanja Kortemme, James S. Fraser, Daniel Asarnow, Evan M. Green, Fatima S. Ugur, David L.V. Bauer, Sophia K. Tan, Joseph L. DeRisi, Beatrice Ary, Yuliya Birman, Tamas L. Nagy, Daniel N. Bolon, Miles Sasha Dickinson, Taia Wu, K. Tsai, Peter F. McTigue, Ruilin Tian, Nicholas J. Rettko, Shizhong Dai, Hiten D. Madhani, Jennifer Y. Li, Douglas Myers-Turnbull, Kevin Lou, Peter J. Rohweder, David Mavor, Daniel M. C. Schwarz, Alison M Maxwell, Erin M. Poss, Cole Helsell, E. Kang, Leanna S. Morinishi, Paul Thomas, Eric D. Chow
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb1693458a8341e04b43f423acafd0d
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(12)
Few chemical strategies for activating enzymes have been developed. Here we show that a biarsenical compound (FlAsH) can directly activate a rationally engineered protein tyrosine phosphatase (Shp2 PTP) via disruption of autoinhibitory interactions b