Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Cynthia Lungu"'
Autor:
Tanvir Hossain, Cynthia Lungu, Sten de Schrijver, Mamokoena Kuali, Raquel Crespo, Nicole Reddy, Ayanda Ngubane, Tsung Wai Kan, Kavidha Reddy, Shringar Rao, Robert-Jan Palstra, Paradise Madlala, Thumbi Ndung’u, Tokameh Mahmoudi
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-16 (2024)
Abstract Background Strategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells such that combination antiretroviral therapy (cART) can be safely interrupted. In order to
Externí odkaz:
https://doaj.org/article/96ec68967979482ebfb2e9618aa6e80f
Autor:
Thessa Laeremans, Sabine den Roover, Cynthia Lungu, Sigrid D’haese, Rob A. Gruters, Sabine D. Allard, Joeri L. Aerts
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Although natural killer (NK) cells have been studied in connection with dendritic cell (DC)-based vaccination in the field of cancer immunology, their role has barely been addressed in the context of therapeutic vaccination against HIV-1. In
Externí odkaz:
https://doaj.org/article/8d718e76751947ccbcc26ed725f9a812
Autor:
Jeroen J.A. van Kampen, Hanh Thi Pham, Sunbin Yoo, Ronald J. Overmars, Cynthia Lungu, Rizwan Mahmud, Carolina A.M. Schurink, Sander van Boheemen, Rob A. Gruters, Pieter L.A. Fraaij, David M. Burger, Jolanda J.C. Voermans, Casper Rokx, David A.M.C. van de Vijver, Thibault Mesplède
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 31, Iss , Pp 323-327 (2022)
ABSTRACT: Objectives: We report a case of incomplete HIV-1 suppression on a dolutegravir, lamivudine, and abacavir single-tablet regimen with the emergence of the H51Y and G118R integrase resistance mutations. Methods: Integrase sequencing was perfor
Externí odkaz:
https://doaj.org/article/0a938eb9f0cb4d779bb3ebd4b1d4ed7e
Autor:
Cynthia Lungu, Ronald J. Overmars, Esmée Grundeken, Patrick H. M. Boers, Marchina E. van der Ende, Thibault Mesplède, Rob A. Gruters
Publikováno v:
Viruses, Vol 15, Iss 11, p 2236 (2023)
Although some individuals with HIV-2 develop severe immunodeficiency and AIDS-related complications, most may never progress to AIDS. Replication-competent HIV-2 isolated from asymptomatic long-term non-progressors (controllers) have lower replicatio
Externí odkaz:
https://doaj.org/article/77e38f7aaf384a6b80059352043cad5b
Autor:
Shringar Rao, Cynthia Lungu, Raquel Crespo, Thijs H. Steijaert, Alicja Gorska, Robert-Jan Palstra, Henrieke A. B. Prins, Wilfred van Ijcken, Yvonne M. Mueller, Jeroen J. A. van Kampen, Annelies Verbon, Peter D. Katsikis, Charles A. B. Boucher, Casper Rokx, Rob A. Gruters, Tokameh Mahmoudi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
DEAD-box polypeptide 3 (DDX3) is a host protein belonging to the family of ATP-dependent RNA helicases. Here, the authors demonstrate that DDX3 inhibitors reverse HIV-1 latency and selectively induce cell death in HIV-1-infected cell lines, primary C
Externí odkaz:
https://doaj.org/article/983a234271bf4954b9536cec417f77df
Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop a
Externí odkaz:
https://doaj.org/article/42383371a44d4c09ab5af6a05357b34f
Autor:
Mateusz Stoszko, Elisa De Crignis, Casper Rokx, Mir Mubashir Khalid, Cynthia Lungu, Robert-Jan Palstra, Tsung Wai Kan, Charles Boucher, Annelies Verbon, Emily C. Dykhuizen, Tokameh Mahmoudi
Publikováno v:
EBioMedicine, Vol 3, Iss C, Pp 108-121 (2016)
Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cel
Externí odkaz:
https://doaj.org/article/63201ca417954753afb8c06cb24c4a67
Autor:
Cynthia Lungu, Francesco A. Procopio, Ronald J. Overmars, Rob J. J. Beerkens, Jolanda J. C. Voermans, Shringar Rao, Henrieke A. B. Prins, Casper Rokx, Giuseppe Pantaleo, David A. M. C. van de Vijver, Tokameh Mahmoudi, Charles A. B. Boucher, Rob A. Gruters, Jeroen J. A. van Kampen
Publikováno v:
Viruses, Vol 12, Iss 9, p 973 (2020)
Substantial efforts to eliminate or reduce latent HIV-1 reservoirs are underway in clinical trials and have created a critical demand for sensitive, accurate, and reproducible tools to evaluate the efficacy of these strategies. Alternative reservoir
Externí odkaz:
https://doaj.org/article/c343245b74494b32b05a015c30171e4e
Publikováno v:
Journal of Virus Eradication, Vol 4, Iss , Pp 28- (2018)
Externí odkaz:
https://doaj.org/article/968f46b7ca8b484eaa08d55c56137f2d
Autor:
Henrieke A. B. Prins, Raquel Crespo, Cynthia Lungu, Shringar Rao, Letao Li, Ronald J. Overmars, Grigorius Papageorgiou, Yvonne M. Mueller, Mateusz Stoszko, Tanvir Hossain, Tsung Wai Kan, Bart J. A. Rijnders, Hannelore I. Bax, Eric C. M. van Gorp, Jan L. Nouwen, Theodora E. M. S. de Vries-Sluijs, Carolina A. M. Schurink, Mariana de Mendonça Melo, Els van Nood, Angela Colbers, David Burger, Robert-Jan Palstra, Jeroen J. A. van Kampen, David A. M. C. van de Vijver, Thibault Mesplède, Peter D. Katsikis, Rob A. Gruters, Birgit C. P. Koch, Annelies Verbon, Tokameh Mahmoudi, Casper Rokx
Publikováno v:
Science Advances, 9
Science Advances, 9, 11
Science advances, 9(11):eade6675. American Association for the Advancement of Science
Science Advances, 9, 11
Science advances, 9(11):eade6675. American Association for the Advancement of Science
Contains fulltext : 291084.pdf (Publisher’s version ) (Open Access) Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3887f3da1a82107e3f551dccee2edb
https://doi.org/10.1126/sciadv.ade6675
https://doi.org/10.1126/sciadv.ade6675