Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Cynthia Lavoie"'
Autor:
Ipshita Nandi, Linjia Ji, Harvey W. Smith, Daina Avizonis, Vasilios Papavasiliou, Cynthia Lavoie, Alain Pacis, Sherif Attalla, Virginie Sanguin-Gendreau, William J. Muller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic reprogramming, a hallmark of tumorigenesis, involves alterations in glucose and fatty acid metabolism. Here, we investigate the role of Carnitine palmitoyl transferase 1a (Cpt1a), a key enzyme in long-chain fatty acid (LCFA) oxidat
Externí odkaz:
https://doaj.org/article/052dee2b00604ae3ada71ece23a9fb36
Autor:
Harvey W. Smith, Alison Hirukawa, Virginie Sanguin-Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack, Matthew Swiatnicki, Cynthia Lavoie, Vasilios Papavasiliou, Carolin Temps, Neil O. Carragher, Asier Unciti-Broceta, Paul Savage, Mark Basik, Vincent van Hoef, Ola Larsson, Caroline L. Cooper, Ana Cristina Vargas Calderon, Jane Beith, Ewan Millar, Christina Selinger, Vincent Giguère, Morag Park, Lyndsay N. Harris, Vinay Varadan, Eran R. Andrechek, Sandra A. O’Toole, Ivan Topisirovic, William J. Muller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH
Externí odkaz:
https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f
Autor:
Alison Hirukawa, Salendra Singh, Jarey Wang, Jonathan P. Rennhack, Matthew Swiatnicki, Virginie Sanguin-Gendreau, Dongmei Zuo, Kamilia Daldoul, Cynthia Lavoie, Morag Park, Eran R. Andrechek, Thomas F. Westbrook, Lyndsay N. Harris, Vinay Varadan, Harvey W. Smith, William J. Muller
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 249-257.e8 (2019)
Summary: Monoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proporti
Externí odkaz:
https://doaj.org/article/d72321d9dd27483ea95dfcd6db827f5b
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
The Supplemental Figure 4 consists in key additionnal data sets to support and supplement Figure 5. Briefly, this supplemental figure 4 shows immunohistochemistry staining performed on FIP1C-MTB-NDL and NIC/FIP1C mammary tumors to examine activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2bc3f6fcd2599559cb809a50a3fc7c
https://doi.org/10.1158/0008-5472.22411998
https://doi.org/10.1158/0008-5472.22411998
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
The Supplemental Figure 2 shows alternative strategy to understand and investigate the pathobiological function of FIP1C in ErbB2-mediated breast cancer progression. Briefly, this supplemental data sets report that we established primary ErbB2/neuNDL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5781a64cfde8833a21afe73421791bb
https://doi.org/10.1158/0008-5472.22412004.v1
https://doi.org/10.1158/0008-5472.22412004.v1
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
The Supplemental Figure 3 contains additionnal and key data sets to supplement the Figure 4. Briefly, we used the FIP1C-proficient and -deficient ErbB2/neuNDL cell lines to confirm the in vivo data related to cell proliferation analysis as presented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5274ffc17e616644ef781255268d022e
https://doi.org/10.1158/0008-5472.22412001.v1
https://doi.org/10.1158/0008-5472.22412001.v1
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
The Supplemental Figure 5 demonstrates that FIP1C does not co-localize with E-cadherin and therefore FIP1C acts indirectly on E-cadherin status in ErbB2-driven model. Additionnally, this Supplemental Figure 5 shows that FIP1C levels is inversely corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386bbc8d24e6706389ac700ab3757f9c
https://doi.org/10.1158/0008-5472.22411995
https://doi.org/10.1158/0008-5472.22411995
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
Rab coupling protein (FIP1C), an effector of the Rab11 GTPases, including Rab25, is amplified and overexpressed in 10% to 25% of primary breast cancers and correlates with poor clinical outcome. Rab25 is also frequently silenced in triple-negative br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::668666a330d7dcac458fe6c82c2a068a
https://doi.org/10.1158/0008-5472.c.6508344.v1
https://doi.org/10.1158/0008-5472.c.6508344.v1
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
This file contains the supplemental figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c82da00d0ede0dc7c3020975dea256f
https://doi.org/10.1158/0008-5472.22411992
https://doi.org/10.1158/0008-5472.22411992
Autor:
William J. Muller, Jim C. Norman, Douglas Strathdee, Lewis Chodosh, Morag Park, Gordon B. Mills, Michael Hallett, Shirley Campbell, Julie M. Livingstone, Shreya Mitra, Laura Jones, Virginie Sanguin-Gendreau, Cynthia Lavoie, Julie-Émilie Huot-Marchand, Jason Turpin, Louise Mitchell, Pierre-Luc Boulay
This file contains supplemental materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76584cb48fbc5a97e53551a6d4966502
https://doi.org/10.1158/0008-5472.22411989.v1
https://doi.org/10.1158/0008-5472.22411989.v1