Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cynthia Lander"'
Autor:
Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. Colazo, Matthew Oliver, Joyce Cheung-Flynn, Colleen M. Brophy, John W. Tierney, Jeffrey S. Isenberg, Kurt D. Hankenson, Kedar Ghimire, Cynthia Lander, Charles A. Gersbach, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide
Externí odkaz:
https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1
Autor:
Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Na Xu, Kritton Shay‐Winkler, James Gulick, Monte S. Willis, Cynthia Lander, Jeffrey Robbins
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 9 (2017)
BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C. Cardiac stress, as well as cMyBP‐C mutations, can trigger production of 1 such truncated prote
Externí odkaz:
https://doaj.org/article/dbc27fe9e550438e858ae6824cb461f1
Autor:
John William Tierney, Juan M. Colazo, Joyce Cheung-Flynn, Brian C. Evans, Kurt D. Hankenson, Kameron V. Kilchrist, Craig L. Duvall, Eric A. Dailing, Kedar Ghimire, Charles A. Gersbach, R. Brock Fletcher, Alvin J. Mukalel, Jeffrey S. Isenberg, Colleen M. Brophy, Cynthia Lander, Matthew J. Oliver
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcaeb154efcfdd5786d63294184b5b0
http://europepmc.org/articles/PMC6825215
http://europepmc.org/articles/PMC6825215
Publikováno v:
International Journal of Peptide Research and Therapeutics. 22:317-324
Acute myocardial infarction (AMI) results in systolic dysfunction, myocarditis and fibrotic remodeling, which causes irreversible pathological remodeling of the heart. Associated cell death and inflammation cause cytokine release, which activates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8d4cb4077bb8be19c3456245d19c65
https://doi.org/10.1007/s10989-015-9507-3
https://doi.org/10.1007/s10989-015-9507-3
Autor:
Ariana Bevilacqua, Lei Xu, Monte S. Willis, W. Cam Patterson, Liang Xie, Cynthia Lander, Jun He, Cecelia C. Yates, Pamela Lockyer
Publikováno v:
Journal of Molecular and Cellular Cardiology. 77:86-101
The cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), MMI-0100, inhibits MK2 and downstream fibrosis and inflammation. Recent studies have demonstrated that MMI-0100 reduces intimal hyperplasia in a mouse vein graft model, pulmonary fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4eea5258bcb64e4059c1cac7d31a84
https://doi.org/10.1016/j.yjmcc.2014.09.011
https://doi.org/10.1016/j.yjmcc.2014.09.011
Autor:
Cynthia Lander, Na Xu, Bidur Bhandary, Monte S. Willis, Jeffrey Robbins, James Gulick, Hanna Osinska, Jeanne James, Kritton Shay-Winkler, Qinghang Meng
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C. Cardiac stress, as well as cMyBP ‐C mutations, can trigger production of 1 such truncated pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c065b397b55579784aa6276b825ed54
https://doi.org/10.1161/jaha.117.006590
https://doi.org/10.1161/jaha.117.006590
Autor:
Ragini Vittal, Elizabeth A. Mickler, Amanda J. Fisher, George E. Sandusky, Alyssa Panitch, Oscar W. Cummings, Cynthia Lander, David S. Wilkes, Hongmei Gu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:47-57
Mitogen-activated protein kinase–activated protein kinase–2 (MAPKAPK2, or MK2), a serine/threonine kinase downstream of p38 mitogen–activated protein kinase, has been implicated in inflammation and fibrosis. Compared with pathologically normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125129757d887aa268faef77cc6f8eeb
https://doi.org/10.1165/rcmb.2012-0389oc
https://doi.org/10.1165/rcmb.2012-0389oc
Autor:
Caryn Petersen, Alyssa Panitch, Colleen M. Brophy, Grant C. Nicholson, Brian Leaker, Cynthia Lander
Publikováno v:
5.1 Airway Pharmacology and Treatment.
Background: Pre-clinical studies demonstrate anti-inflammatory and anti-fibrotic properties of MMI-0100, a peptide inhibitor of mitogen-activated protein kinase-activated protein kinase II (MK2). Aims: Phase I double blind randomised multiple dose (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e872f76ac9a6cfbc2b0ee2236e49290
https://doi.org/10.1183/13993003.congress-2016.oa3542
https://doi.org/10.1183/13993003.congress-2016.oa3542
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
Objective The human saphenous vein (HSV) is the most effective conduit for infrainguinal peripheral bypass grafting. Optimal vein graft preparation is critical to vein graft patency. Graft marking using surgical skin markers is detrimental to endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ac8c1c2acf70897c40aa5d4e43b0a1
https://doi.org/10.1161/atvb.33.suppl_1.a204
https://doi.org/10.1161/atvb.33.suppl_1.a204
Autor:
David S. Wilkes, Cynthia Lander, Oscar W. Cummings, Amanda Fisher, Ragini Vittal, Alyssa Panitch, Elizabeth A. Mickler
Publikováno v:
A61. ANTIFIBROTICS AND THERAPEUTIC TARGETS IN EXPERIMENTAL LUNG FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9511d119bc6780395d5d89acd3d466e9
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1947
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1947