Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Cynthia L. Pon"'
Autor:
Claudio O. Gualerzi, Anna Maria Giuliodori, Enrico Caserta, Arianna Smorlesi, Cynthia L. Pon, Jerneja Tomšic
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 735 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences
Volume 21
Issue 3
The conserved Histidine 301 in switch II of Geobacillus stearothermophilus IF2 G2 domain was substituted with Ser, Gln, Arg, Leu and Tyr to generate mutants displaying different phenotypes. Overexpression of IF2H301S, IF2H301L and IF2H301Y in cells e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0341c728e2c4ea756812567f1e3cd2
https://www.mdpi.com/1422-0067/21/3/735
https://www.mdpi.com/1422-0067/21/3/735
Autor:
Jerneja, Tomsic, Arianna, Smorlesi, Enrico, Caserta, Anna Maria, Giuliodori, Cynthia L, Pon, Claudio O, Gualerzi
Publikováno v:
International Journal of Molecular Sciences
The conserved Histidine 301 in switch II of Geobacillus stearothermophilus IF2 G2 domain was substituted with Ser, Gln, Arg, Leu and Tyr to generate mutants displaying different phenotypes. Overexpression of IF2H301S, IF2H301L and IF2H301Y in cells e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db32ab47f3ea6112a6cc6d77b7572f02
https://pubmed.ncbi.nlm.nih.gov/31979156
https://pubmed.ncbi.nlm.nih.gov/31979156
Autor:
Anna Brandi, Mara Giangrossi, Anna Maria Giuliodori, Claudio O. Gualerzi, Cynthia L. Pon, Silvia Paoloni, Roberto Spurio
Publikováno v:
Nucleic Acids Research
After a 37 to 10°C temperature downshift the level of translation initiation factor IF2, like that of IF1 and IF3, increases at least 3-fold with respect to the ribosomes. To clarify the mechanisms and conditions leading to cold-stress induction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a03d59d8e9f70c1fa83eb589c8677b
http://hdl.handle.net/11581/426034
http://hdl.handle.net/11581/426034
Autor:
Paola Sabatini, Cynthia L. Pon, He Chengguang, Letizia Brandi, Claudio O. Gualerzi, Anna Maria Giuliodori
Publikováno v:
Nucleic Acids Research
To assess the influence of degenerate initiation triplets on mRNA recruitment by ribosomes, five mRNAs identical but for their start codon (AUG, GUG, UUG, AUU and AUA) were offered to a limiting amount of ribosomes, alone or in competition with an id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436fde0f4660a5163ad2cccd20340b67
http://hdl.handle.net/11581/426308
http://hdl.handle.net/11581/426308
Autor:
Anna Brandi, Cynthia L. Pon, Lolita Piersimoni, Claudio O. Gualerzi, Paolo Marchi, Mara Giangrossi
Publikováno v:
Journal of molecular biology. 428(8)
During the cold adaptation that follows a cold stress, bacterial cells undergo many physiological changes and extensive reprogramming of their gene expression pattern. Bulk gene expression is drastically reduced, while a set of cold shock genes is se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b700b205ecd1a4b5cebf3fb965c62653
https://pubmed.ncbi.nlm.nih.gov/26953262
https://pubmed.ncbi.nlm.nih.gov/26953262
Autor:
Cynthia L. Pon, Attilio Fabbretti, Pohl Milón, Roberto Spurio, Claudio O. Gualerzi, Letizia Brandi
Publikováno v:
Nucleic Acids Research
Translation initiation factor IF2 is a guanine nucleotide-binding protein. The free energy change associated with guanosine triphosphate hydrolase (GTPase) activity of these proteins is believed to be the driving force allowing them to perform their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bd81dcaacc6bad6b51056a76b6eeca
https://doi.org/10.1093/nar/gks569
https://doi.org/10.1093/nar/gks569
Autor:
Carlotta Ferrara, Pohl Milón, Jerneja Tomšic, Enrico Caserta, Alessandra Rocchetti, Claudio O. Gualerzi, Anna La Teana, Cynthia L. Pon, Attilio Fabbretti
Publikováno v:
Journal of Molecular Biology. 396:118-129
InfB-encoded translation initiation factor IF2 contains a non-conserved N-terminal domain and two conserved domains (G and C) constituted by three (G1, G2 and G3) and two (C1 and C2) sub-domains. Here, we show that: (i) Bacillus stearothermophilus IF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16752ce87f38491b1bdcd426562501f
https://doi.org/10.1016/j.jmb.2009.11.026
https://doi.org/10.1016/j.jmb.2009.11.026
Autor:
Gaetano Barbato, Anna Brandi, Rolf Boelens, Cynthia L. Pon, Edoardo Trotta, Claudio O. Gualerzi, Marco Sette, Roberto Spurio, Cinzia Brandizi
Publikováno v:
Journal of Biological Chemistry. 284:30453-30462
The molecular determinants necessary and sufficient for recognition of its specific DNA target are contained in the C-terminal domain (H-NSctd) of nucleoid-associated protein H-NS. H-NSctd protects from DNaseI cleavage a few short DNA segments of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13404aba24c123d73cf5638c3fb84e2f
https://doi.org/10.1074/jbc.m109.044313
https://doi.org/10.1074/jbc.m109.044313
Autor:
Claudio O. Gualerzi, Cynthia L. Pon
Publikováno v:
Cellular and Molecular Life Sciences
Initiation of mRNA translation is a major checkpoint for regulating level and fidelity of protein synthesis. Being rate limiting in protein synthesis, translation initiation also represents the target of many post-transcriptional mechanisms regulatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633151dc7680ec558ae8a77f0ec266eb
https://pubmed.ncbi.nlm.nih.gov/26259514
https://pubmed.ncbi.nlm.nih.gov/26259514
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to anti